Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193692369> ?p ?o ?g. }
- W3193692369 abstract "ABSTRACT The complexity of the metazoan proteome is significantly increased by the expression of small proteins (<100 aas) derived from smORFs within lncRNAs, uORFs, 3’ UTRs and, more rarely, reading frames overlapping the CDS. These smORF encoded proteins (SEPs) can have diverse roles, ranging from the regulation of cellular physiological to essential developmental functions. We report the characterisation of a new member of this protein family, SEP 53BP1 , derived from a small internal ORF that overlaps the CDS that encodes 53BP1. Its expression is coupled to the utilisation of an alternative, cell-type specific, promoter coupled to translational reinitiation events mediated by a uORF in the alternative 5’ TL of the mRNA. The uORF-mediated initiation at the internal AUG 53BP1 is conserved in metazoan species ranging from human to zebrafish. As such, it couples SEP 53BP1 expression to the integrated stress response (ISR). We demonstrate that one function of this protein is to interact with, and stimulate, the activity of the 26S proteasome. As such, it opens the door to new approaches in the treatment of clinical conditions that arise due to the accumulation of toxic intracellular protein aggregates" @default.
- W3193692369 created "2021-08-30" @default.
- W3193692369 creator A5000907413 @default.
- W3193692369 creator A5003534838 @default.
- W3193692369 creator A5013082040 @default.
- W3193692369 creator A5017961862 @default.
- W3193692369 creator A5046242556 @default.
- W3193692369 date "2021-08-23" @default.
- W3193692369 modified "2023-10-14" @default.
- W3193692369 title "A small protein, derived from an alternative 53BP1 promoter transcript and expressed via translational reinitiation on an internal overlapping ORF, modulates proteasome activity" @default.
- W3193692369 cites W1573531091 @default.
- W3193692369 cites W1724359866 @default.
- W3193692369 cites W1799375255 @default.
- W3193692369 cites W1870605585 @default.
- W3193692369 cites W1882115849 @default.
- W3193692369 cites W1882986874 @default.
- W3193692369 cites W1965581086 @default.
- W3193692369 cites W1970569349 @default.
- W3193692369 cites W1976641851 @default.
- W3193692369 cites W1978417963 @default.
- W3193692369 cites W1982444105 @default.
- W3193692369 cites W1988001471 @default.
- W3193692369 cites W1988148406 @default.
- W3193692369 cites W1988448896 @default.
- W3193692369 cites W1999506801 @default.
- W3193692369 cites W2001969615 @default.
- W3193692369 cites W2010075485 @default.
- W3193692369 cites W2010690249 @default.
- W3193692369 cites W2017671645 @default.
- W3193692369 cites W2023011588 @default.
- W3193692369 cites W2024116262 @default.
- W3193692369 cites W2024144538 @default.
- W3193692369 cites W2024644454 @default.
- W3193692369 cites W2025714022 @default.
- W3193692369 cites W2027195993 @default.
- W3193692369 cites W2027453759 @default.
- W3193692369 cites W2033056717 @default.
- W3193692369 cites W2033492309 @default.
- W3193692369 cites W2040415319 @default.
- W3193692369 cites W2045022080 @default.
- W3193692369 cites W2046909544 @default.
- W3193692369 cites W2049250303 @default.
- W3193692369 cites W2052772529 @default.
- W3193692369 cites W2058977593 @default.
- W3193692369 cites W2059143988 @default.
- W3193692369 cites W2067427915 @default.
- W3193692369 cites W2067678127 @default.
- W3193692369 cites W2067700675 @default.
- W3193692369 cites W2068696470 @default.
- W3193692369 cites W2069723920 @default.
- W3193692369 cites W2071849521 @default.
- W3193692369 cites W2078266900 @default.
- W3193692369 cites W2079517684 @default.
- W3193692369 cites W2084891010 @default.
- W3193692369 cites W2093657684 @default.
- W3193692369 cites W2094074349 @default.
- W3193692369 cites W2097409962 @default.
- W3193692369 cites W2100424218 @default.
- W3193692369 cites W2102050179 @default.
- W3193692369 cites W2103862461 @default.
- W3193692369 cites W2105881882 @default.
- W3193692369 cites W2111426001 @default.
- W3193692369 cites W2116654909 @default.
- W3193692369 cites W2117200085 @default.
- W3193692369 cites W2118151959 @default.
- W3193692369 cites W2122064342 @default.
- W3193692369 cites W2125763071 @default.
- W3193692369 cites W2140491044 @default.
- W3193692369 cites W2146488386 @default.
- W3193692369 cites W2147722710 @default.
- W3193692369 cites W2148350911 @default.
- W3193692369 cites W2149661661 @default.
- W3193692369 cites W2150123812 @default.
- W3193692369 cites W2150901760 @default.
- W3193692369 cites W2152974197 @default.
- W3193692369 cites W2153521373 @default.
- W3193692369 cites W2154128645 @default.
- W3193692369 cites W2160102110 @default.
- W3193692369 cites W2179147211 @default.
- W3193692369 cites W2179178090 @default.
- W3193692369 cites W2190668035 @default.
- W3193692369 cites W2205343347 @default.
- W3193692369 cites W2255242978 @default.
- W3193692369 cites W2256024411 @default.
- W3193692369 cites W2282922301 @default.
- W3193692369 cites W2288126248 @default.
- W3193692369 cites W2302904268 @default.
- W3193692369 cites W2306137721 @default.
- W3193692369 cites W2331218777 @default.
- W3193692369 cites W2398612826 @default.
- W3193692369 cites W2411831786 @default.
- W3193692369 cites W2427010553 @default.
- W3193692369 cites W2508930612 @default.
- W3193692369 cites W2518959324 @default.
- W3193692369 cites W2546798460 @default.
- W3193692369 cites W2579217144 @default.
- W3193692369 cites W2617007369 @default.
- W3193692369 cites W2625523848 @default.
- W3193692369 cites W2734798616 @default.
- W3193692369 cites W2775215876 @default.