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- W3193702067 abstract "Drug delivery systems (DDS) that can temporally control the rate and extent of release of therapeutically active molecules find applications in many clinical settings, ranging from infection control to cancer therapy. With an aim to design a locally implantable, controlled-release DDS, we demonstrated the feasibility of using cellulose nanocrystal (CNC)-reinforced poly (l-lactic acid) (PLA) composite beads. The performance of the platform was evaluated using doxorubicin (DOX) as a model drug for applications in triple-negative breast cancer. A facile, nonsolvent-induced phase separation (NIPS) method was adopted to form composite beads. We observed that CNC loading within these beads played a critical role in the mechanical stability, porosity, water uptake, diffusion, release, and pharmacological activity of the drug from the delivery system. When loaded with DOX, composite beads significantly controlled the release of the drug in a pH-dependent pattern. For example, PLA/CNC beads containing 37.5 wt % of CNCs showed a biphasic release of DOX, where 41 and 82% of the loaded drug were released at pH 7.4 and pH 5.5, respectively, over 7 days. Drug release followed Korsmeyer's kinetics, indicating that the release mechanism was mostly diffusion and swelling-controlled. We showed that DOX released from drug-loaded PLA/CNC composite beads locally suppressed the growth and proliferation of triple-negative breast cancer cells, MBA-MB-231, via the apoptotic pathway. The efficacy of the DDS was evaluated in human tissue explants. We envision that such systems will find applications for designing biobased platforms with programmed stability and drug delivery functions." @default.
- W3193702067 created "2021-08-30" @default.
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- W3193702067 date "2021-08-23" @default.
- W3193702067 modified "2023-10-18" @default.
- W3193702067 title "Polymeric Composite Matrix with High Biobased Content as Pharmaceutically Relevant Molecular Encapsulation and Release Platform" @default.
- W3193702067 cites W1543693818 @default.
- W3193702067 cites W1608114689 @default.
- W3193702067 cites W1650741782 @default.
- W3193702067 cites W1756838878 @default.
- W3193702067 cites W1964491709 @default.
- W3193702067 cites W1967587789 @default.
- W3193702067 cites W1972182786 @default.
- W3193702067 cites W1973340419 @default.
- W3193702067 cites W1974000574 @default.
- W3193702067 cites W1975109456 @default.
- W3193702067 cites W1977072597 @default.
- W3193702067 cites W1980328470 @default.
- W3193702067 cites W1982041674 @default.
- W3193702067 cites W1983700598 @default.
- W3193702067 cites W1984903735 @default.
- W3193702067 cites W1987281985 @default.
- W3193702067 cites W1987392736 @default.
- W3193702067 cites W1992587280 @default.
- W3193702067 cites W2000282053 @default.
- W3193702067 cites W2001089765 @default.
- W3193702067 cites W2004013743 @default.
- W3193702067 cites W2011546003 @default.
- W3193702067 cites W2014779949 @default.
- W3193702067 cites W2022981155 @default.
- W3193702067 cites W2024262973 @default.
- W3193702067 cites W2027147390 @default.
- W3193702067 cites W2028892040 @default.
- W3193702067 cites W2032090704 @default.
- W3193702067 cites W2035006802 @default.
- W3193702067 cites W2036443620 @default.
- W3193702067 cites W2040133519 @default.
- W3193702067 cites W2043170261 @default.
- W3193702067 cites W2049930363 @default.
- W3193702067 cites W2050263372 @default.
- W3193702067 cites W2058351664 @default.
- W3193702067 cites W2059815320 @default.
- W3193702067 cites W2060073729 @default.
- W3193702067 cites W2062450561 @default.
- W3193702067 cites W2067244936 @default.
- W3193702067 cites W2067673936 @default.
- W3193702067 cites W2069356132 @default.
- W3193702067 cites W2073256974 @default.
- W3193702067 cites W2074790161 @default.
- W3193702067 cites W2079616953 @default.
- W3193702067 cites W2082440952 @default.
- W3193702067 cites W2083094408 @default.
- W3193702067 cites W2085437700 @default.
- W3193702067 cites W2086971118 @default.
- W3193702067 cites W2087496871 @default.
- W3193702067 cites W2089097993 @default.
- W3193702067 cites W2089684887 @default.
- W3193702067 cites W2092047413 @default.
- W3193702067 cites W2094448210 @default.
- W3193702067 cites W2095565216 @default.
- W3193702067 cites W2096642137 @default.
- W3193702067 cites W2100567246 @default.
- W3193702067 cites W2102999763 @default.
- W3193702067 cites W2107394367 @default.
- W3193702067 cites W2109818109 @default.
- W3193702067 cites W2121682430 @default.
- W3193702067 cites W2133338994 @default.
- W3193702067 cites W2136205561 @default.
- W3193702067 cites W2138714913 @default.
- W3193702067 cites W2144646631 @default.
- W3193702067 cites W2147329481 @default.
- W3193702067 cites W2150517485 @default.
- W3193702067 cites W2158584176 @default.
- W3193702067 cites W2160466249 @default.
- W3193702067 cites W2170456951 @default.
- W3193702067 cites W2170498612 @default.
- W3193702067 cites W2171751070 @default.
- W3193702067 cites W2187006386 @default.
- W3193702067 cites W2189233988 @default.
- W3193702067 cites W2219994541 @default.
- W3193702067 cites W2292253603 @default.
- W3193702067 cites W2414230095 @default.
- W3193702067 cites W2464645057 @default.
- W3193702067 cites W2466620019 @default.
- W3193702067 cites W2483951716 @default.
- W3193702067 cites W2509386388 @default.
- W3193702067 cites W2554451310 @default.
- W3193702067 cites W2558162361 @default.
- W3193702067 cites W2567613753 @default.