Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193710130> ?p ?o ?g. }
- W3193710130 abstract "Neutrophils have been described as a phenotypically heterogeneous cell type that possess both pro- and anti-tumor properties. Recently, a subset of neutrophils isolated from the peripheral blood mononuclear cell (PBMC) fraction has been described in cancer patients. These low-density neutrophils (LDNs) show a heterogeneous maturation state and have been associated with pro-tumor properties in comparison to mature, high-density neutrophils (HDNs). However, additional studies are necessary to characterize this cell population. Here we show new surface markers that allow us to discriminate between LDNs and HDNs in non-small cell lung cancer (NSCLC) patients and assess their potential as diagnostic/prognostic tool. LDNs were highly enriched in NSCLC patients (median=20.4%, range 0.3-76.1%; n=26) but not in healthy individuals (median=0.3%, range 0.1-3.9%; n=14). Using a high-dimensional human cell surface marker screen, we identified 12 surface markers that were downregulated in LDNs when compared to HDNs, while 41 surface markers were upregulated in the LDN subset. Using flow cytometry, we confirmed overexpression of CD36, CD41, CD61 and CD226 in the LDN fraction. In summary, our data support the notion that LDNs are a unique neutrophil population and provide novel targets to clarify their role in tumor progression and their potential as diagnostic and therapeutic tool." @default.
- W3193710130 created "2021-08-30" @default.
- W3193710130 creator A5006321692 @default.
- W3193710130 creator A5006483196 @default.
- W3193710130 creator A5008307385 @default.
- W3193710130 creator A5018476396 @default.
- W3193710130 creator A5020587998 @default.
- W3193710130 creator A5026303219 @default.
- W3193710130 creator A5033773839 @default.
- W3193710130 creator A5040676467 @default.
- W3193710130 creator A5052743376 @default.
- W3193710130 creator A5069741150 @default.
- W3193710130 creator A5073544161 @default.
- W3193710130 creator A5076185677 @default.
- W3193710130 creator A5082520810 @default.
- W3193710130 creator A5041236798 @default.
- W3193710130 creator A5091348116 @default.
- W3193710130 date "2021-08-13" @default.
- W3193710130 modified "2023-10-15" @default.
- W3193710130 title "Identification of Novel Low-Density Neutrophil Markers Through Unbiased High-Dimensional Flow Cytometry Screening in Non-Small Cell Lung Cancer Patients" @default.
- W3193710130 cites W1485702100 @default.
- W3193710130 cites W1532094402 @default.
- W3193710130 cites W1564279536 @default.
- W3193710130 cites W1698298474 @default.
- W3193710130 cites W1979952143 @default.
- W3193710130 cites W1980148430 @default.
- W3193710130 cites W1982906652 @default.
- W3193710130 cites W1984747276 @default.
- W3193710130 cites W2002157461 @default.
- W3193710130 cites W2003268223 @default.
- W3193710130 cites W2014466662 @default.
- W3193710130 cites W2017174354 @default.
- W3193710130 cites W2017338571 @default.
- W3193710130 cites W2019209583 @default.
- W3193710130 cites W2020327043 @default.
- W3193710130 cites W2024492396 @default.
- W3193710130 cites W2044748328 @default.
- W3193710130 cites W2048270768 @default.
- W3193710130 cites W2064315259 @default.
- W3193710130 cites W2067931754 @default.
- W3193710130 cites W2081862447 @default.
- W3193710130 cites W2085458222 @default.
- W3193710130 cites W2088067478 @default.
- W3193710130 cites W2099635702 @default.
- W3193710130 cites W2106107739 @default.
- W3193710130 cites W2114673516 @default.
- W3193710130 cites W2132132140 @default.
- W3193710130 cites W2141186997 @default.
- W3193710130 cites W2151832198 @default.
- W3193710130 cites W2152677909 @default.
- W3193710130 cites W2168205651 @default.
- W3193710130 cites W2206568619 @default.
- W3193710130 cites W2311944553 @default.
- W3193710130 cites W2325223081 @default.
- W3193710130 cites W2325356223 @default.
- W3193710130 cites W2342338374 @default.
- W3193710130 cites W2371557815 @default.
- W3193710130 cites W2411767313 @default.
- W3193710130 cites W2466033276 @default.
- W3193710130 cites W2471500324 @default.
- W3193710130 cites W2474950788 @default.
- W3193710130 cites W2488076079 @default.
- W3193710130 cites W2545015297 @default.
- W3193710130 cites W2570947205 @default.
- W3193710130 cites W2584487585 @default.
- W3193710130 cites W2731059180 @default.
- W3193710130 cites W2795636496 @default.
- W3193710130 cites W2809255841 @default.
- W3193710130 cites W2890888106 @default.
- W3193710130 cites W2955177546 @default.
- W3193710130 cites W2964245665 @default.
- W3193710130 cites W3002130265 @default.
- W3193710130 cites W3003526695 @default.
- W3193710130 cites W3028322703 @default.
- W3193710130 cites W3121909514 @default.
- W3193710130 cites W3128646645 @default.
- W3193710130 doi "https://doi.org/10.3389/fimmu.2021.703846" @default.
- W3193710130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8414579" @default.
- W3193710130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34484199" @default.
- W3193710130 hasPublicationYear "2021" @default.
- W3193710130 type Work @default.
- W3193710130 sameAs 3193710130 @default.
- W3193710130 citedByCount "11" @default.
- W3193710130 countsByYear W31937101302022 @default.
- W3193710130 countsByYear W31937101302023 @default.
- W3193710130 crossrefType "journal-article" @default.
- W3193710130 hasAuthorship W3193710130A5006321692 @default.
- W3193710130 hasAuthorship W3193710130A5006483196 @default.
- W3193710130 hasAuthorship W3193710130A5008307385 @default.
- W3193710130 hasAuthorship W3193710130A5018476396 @default.
- W3193710130 hasAuthorship W3193710130A5020587998 @default.
- W3193710130 hasAuthorship W3193710130A5026303219 @default.
- W3193710130 hasAuthorship W3193710130A5033773839 @default.
- W3193710130 hasAuthorship W3193710130A5040676467 @default.
- W3193710130 hasAuthorship W3193710130A5041236798 @default.
- W3193710130 hasAuthorship W3193710130A5052743376 @default.
- W3193710130 hasAuthorship W3193710130A5069741150 @default.
- W3193710130 hasAuthorship W3193710130A5073544161 @default.
- W3193710130 hasAuthorship W3193710130A5076185677 @default.
- W3193710130 hasAuthorship W3193710130A5082520810 @default.