FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193722669> ?p ?o ?g. }

• W3193722669 endingPage "121067" @default.
• W3193722669 startingPage "121067" @default.
• W3193722669 abstract "Epithelial cell therapies have been at an impasse because of inefficient methods of transplantation to solid organs. Patch grafting strategies were established enabling transplantation of ≥107th organoids/patch of porcine GFP+ biliary tree stem/progenitors into livers of wild type hosts. Grafts consisted of organoids embedded in soft (~100 Pa) hyaluronan hydrogels, both prepared in serum-free Kubota's Medium; placed against target sites; covered with a silk backing impregnated with more rigid hyaluronan hydrogels (~700 Pa); and use of the backing to tether grafts with sutures or glue to target sites. Hyaluronan coatings (~200-300 Pa) onto the serosal surface of the graft served to minimize adhesions with neighboring organs. The organ's clearance of hyaluronans enabled restoration of tissue-specific paracrine and systemic signaling, resulting in return of normal hepatic histology, with donor parenchymal cells uniformly integrated amidst host cells and that had differentiated to mature hepatocytes and cholangiocytes. Grafts containing donor mature hepatocytes, partnered with endothelia, and in the same graft biomaterials as for stem/progenitor organoids, did not engraft. Engraftment occurred if porcine liver-derived mesenchymal stem cells (MSCs) were co-transplanted with donor mature cells. RNA-seq analyses revealed that engraftment correlated with expression of matrix-metalloproteinases (MMPs), especially secreted isoforms that were found expressed strongly by organoids, less so by MSCs, and minimally, if at all, by adult cells. Engraftment with patch grafting strategies occurred without evidence of emboli or ectopic cell distribution. It was successful with stem/progenitor organoids or with cells with a source(s) of secreted MMP isoforms and offers significant potential for enabling cell therapies for solid organs." @default.
• W3193722669 created "2021-08-30" @default.
• W3193722669 creator A5001479939 @default.
• W3193722669 creator A5008060564 @default.
• W3193722669 creator A5008764552 @default.
• W3193722669 creator A5011930729 @default.
• W3193722669 creator A5021550395 @default.
• W3193722669 creator A5027095830 @default.
• W3193722669 creator A5034481559 @default.
• W3193722669 creator A5036836747 @default.
• W3193722669 creator A5039839564 @default.
• W3193722669 creator A5042227716 @default.
• W3193722669 creator A5045839264 @default.
• W3193722669 creator A5051225718 @default.
• W3193722669 creator A5054542235 @default.
• W3193722669 creator A5058987399 @default.
• W3193722669 creator A5059963876 @default.
• W3193722669 creator A5061717187 @default.
• W3193722669 creator A5072537482 @default.
• W3193722669 creator A5073258673 @default.
• W3193722669 creator A5078840896 @default.
• W3193722669 creator A5079442325 @default.
• W3193722669 creator A5081350888 @default.
• W3193722669 creator A5087826692 @default.
• W3193722669 creator A5088497410 @default.
• W3193722669 creator A5089231537 @default.
• W3193722669 creator A5089718822 @default.
• W3193722669 date "2021-10-01" @default.
• W3193722669 modified "2023-09-29" @default.
• W3193722669 title "Patch grafting, strategies for transplantation of organoids into solid organs such as liver" @default.
• W3193722669 cites W1174494744 @default.
• W3193722669 cites W1501158614 @default.
• W3193722669 cites W1508026137 @default.
• W3193722669 cites W1547497405 @default.
• W3193722669 cites W155154475 @default.
• W3193722669 cites W1580893558 @default.
• W3193722669 cites W1600024584 @default.
• W3193722669 cites W1950749075 @default.
• W3193722669 cites W1976183817 @default.
• W3193722669 cites W1985109279 @default.
• W3193722669 cites W1993102230 @default.
• W3193722669 cites W1999889167 @default.
• W3193722669 cites W2006632334 @default.
• W3193722669 cites W2014214553 @default.
• W3193722669 cites W2014233742 @default.
• W3193722669 cites W2021718747 @default.
• W3193722669 cites W2023987379 @default.
• W3193722669 cites W2024058225 @default.
• W3193722669 cites W2035515342 @default.
• W3193722669 cites W2037432727 @default.
• W3193722669 cites W2037747858 @default.
• W3193722669 cites W2048755804 @default.
• W3193722669 cites W2073653014 @default.
• W3193722669 cites W2078785430 @default.
• W3193722669 cites W2082602763 @default.
• W3193722669 cites W2082932879 @default.
• W3193722669 cites W2086342761 @default.
• W3193722669 cites W2089537633 @default.
• W3193722669 cites W2089752542 @default.
• W3193722669 cites W2089756144 @default.
• W3193722669 cites W2090239109 @default.
• W3193722669 cites W2100238813 @default.
• W3193722669 cites W2100465544 @default.
• W3193722669 cites W2102765643 @default.
• W3193722669 cites W2137668099 @default.
• W3193722669 cites W2139660464 @default.
• W3193722669 cites W2139966914 @default.
• W3193722669 cites W2149884610 @default.
• W3193722669 cites W2184511333 @default.
• W3193722669 cites W2192188808 @default.
• W3193722669 cites W2224764124 @default.
• W3193722669 cites W2326177750 @default.
• W3193722669 cites W2339919017 @default.
• W3193722669 cites W2387942348 @default.
• W3193722669 cites W2401307460 @default.
• W3193722669 cites W2414895142 @default.
• W3193722669 cites W2574645312 @default.
• W3193722669 cites W2599889833 @default.
• W3193722669 cites W2603375353 @default.
• W3193722669 cites W2729309989 @default.
• W3193722669 cites W2736009495 @default.
• W3193722669 cites W2763336761 @default.
• W3193722669 cites W2767349973 @default.
• W3193722669 cites W2768970576 @default.
• W3193722669 cites W2799927617 @default.
• W3193722669 cites W2805339388 @default.
• W3193722669 cites W2914843740 @default.
• W3193722669 cites W2939637750 @default.
• W3193722669 cites W3006027658 @default.
• W3193722669 cites W3010217167 @default.
• W3193722669 cites W3170791627 @default.
• W3193722669 cites W4229796538 @default.
• W3193722669 doi "https://doi.org/10.1016/j.biomaterials.2021.121067" @default.
• W3193722669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34517276" @default.
• W3193722669 hasPublicationYear "2021" @default.
• W3193722669 type Work @default.
• W3193722669 sameAs 3193722669 @default.
• W3193722669 citedByCount "10" @default.

• next