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- W3193775025 abstract "Abstract Chlorpyrifos (CPF) is an extensively used organophosphate pesticide for crop protection. However, there are concerns of it contaminating the environment and human health with estimated three lakh deaths annually. Detection of CPF in blood samples holds significance to avoid severe health outcomes due to continuous exposure. The most common techniques for CPF detection are Gas chromatography (GC) and high-performance liquid chromatography (HPLC). However, these techniques might not be feasible at the community healthcare level due to high-cost instrumentation, time-consuming sample preparation protocol and skilled analysts. Therefore, rapid, effective and economical methods such as immunoassay would be imperative for CPF detection in biological samples. The vital step in immunoassay development is the design of a potent immunogen from non-immunogenic molecules. The molecular modelling protocol could assist in redesigning known CPF linkers and inserting them at different substitutable positions of CPF to get distinctive CPF derivatives. Molecular docking and binding free energy analysis can be used to identify the CPF derivatives having a better binding affinity with carrier protein compared to CPF. The top-ranked CPF derivatives based on docking score and binding energy could be ideal for synthesis and immunogen development. The present review will comprehend technological trends in immunoassay kits for detecting chlorpyrifos from biological samples." @default.
- W3193775025 created "2021-08-30" @default.
- W3193775025 creator A5047353854 @default.
- W3193775025 creator A5054476958 @default.
- W3193775025 creator A5058533879 @default.
- W3193775025 creator A5070834995 @default.
- W3193775025 creator A5071587604 @default.
- W3193775025 creator A5091489138 @default.
- W3193775025 date "2021-08-03" @default.
- W3193775025 modified "2023-09-27" @default.
- W3193775025 title "Immunoassay-based approaches for development of screening of chlorpyrifos" @default.
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