Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193802004> ?p ?o ?g. }
- W3193802004 endingPage "855" @default.
- W3193802004 startingPage "843" @default.
- W3193802004 abstract "Platelets are thought to be involved in the pathophysiology of asthma, presumably through direct adhesion to inflammatory cells, including group 2 innate lymphoid cells (ILC2s). Here, we tried to elucidate the effects of platelet adhesion to ILC2s in vitro and in vivo, as well as the mechanisms involved.Alternaria-induced ILC2-dependent airway inflammation models using wild-type and c-mpl-/- mice were evaluated. Both purified CD41+ and CD41- ILC2s were cultured with IL-2 and IL-33 to determine in vitro Type 2 (T2) cytokine production and cell proliferation. RNA-seq data of flow-cytometry-sorted CD41+ and CD41- ILC2s were used to isolate ILC2-specific genes. Flow cytometry was performed to determine the expression of CD41 and adhesion-related molecules on ILC2s in both mouse and human tissues.T2 inflammation and T2 cytokine production from ILC2s were significantly reduced in the c-mpl-/- mice compared to wild-type mice. Platelet-adherent ILC2s underwent significant proliferation and showed enhanced T2 cytokine production when exposed to IL-2 and IL-33. The functions of ILC2-specific genes were related to cell development and function. Upstream regulator analysis identified 15 molecules, that are thought to be involved in ILC2 activation. CD41 expression levels were higher in ILC2s from human PBMCs and mouse lung than in those from secondary lymphoid tissues, but they did not correlate with the P-selectin glycoprotein ligand-1 or CD24 expression level.Platelets spontaneously adhere to ILC2s, probably in the peripheral blood and airways, thereby potentiating ILC2s to enhance their responses to IL-33." @default.
- W3193802004 created "2021-08-30" @default.
- W3193802004 creator A5010869573 @default.
- W3193802004 creator A5012874527 @default.
- W3193802004 creator A5013443180 @default.
- W3193802004 creator A5016086834 @default.
- W3193802004 creator A5016886169 @default.
- W3193802004 creator A5022822906 @default.
- W3193802004 creator A5026587210 @default.
- W3193802004 creator A5028027722 @default.
- W3193802004 creator A5033477948 @default.
- W3193802004 creator A5037426265 @default.
- W3193802004 creator A5044502423 @default.
- W3193802004 creator A5044756754 @default.
- W3193802004 creator A5046225422 @default.
- W3193802004 creator A5053231538 @default.
- W3193802004 creator A5055404517 @default.
- W3193802004 creator A5066775767 @default.
- W3193802004 creator A5068436726 @default.
- W3193802004 creator A5072486592 @default.
- W3193802004 creator A5073309319 @default.
- W3193802004 creator A5073531170 @default.
- W3193802004 creator A5073839222 @default.
- W3193802004 creator A5075606543 @default.
- W3193802004 creator A5076528398 @default.
- W3193802004 creator A5076807569 @default.
- W3193802004 creator A5079099744 @default.
- W3193802004 creator A5084796540 @default.
- W3193802004 creator A5088080931 @default.
- W3193802004 date "2021-08-24" @default.
- W3193802004 modified "2023-10-10" @default.
- W3193802004 title "Direct platelet adhesion potentiates group 2 innate lymphoid cell functions" @default.
- W3193802004 cites W1484715519 @default.
- W3193802004 cites W1497519679 @default.
- W3193802004 cites W1522536354 @default.
- W3193802004 cites W1526907282 @default.
- W3193802004 cites W1932484161 @default.
- W3193802004 cites W1976954262 @default.
- W3193802004 cites W1979438759 @default.
- W3193802004 cites W2004716180 @default.
- W3193802004 cites W2015109688 @default.
- W3193802004 cites W2036853705 @default.
- W3193802004 cites W2037749979 @default.
- W3193802004 cites W2050701385 @default.
- W3193802004 cites W2062931149 @default.
- W3193802004 cites W2085393172 @default.
- W3193802004 cites W2103572248 @default.
- W3193802004 cites W2121530525 @default.
- W3193802004 cites W2125573114 @default.
- W3193802004 cites W2129688962 @default.
- W3193802004 cites W2153384424 @default.
- W3193802004 cites W2160471996 @default.
- W3193802004 cites W2165638693 @default.
- W3193802004 cites W2323768961 @default.
- W3193802004 cites W2469405532 @default.
- W3193802004 cites W2546443879 @default.
- W3193802004 cites W2766224334 @default.
- W3193802004 cites W2769375719 @default.
- W3193802004 cites W2774218093 @default.
- W3193802004 cites W2774709485 @default.
- W3193802004 cites W2791687636 @default.
- W3193802004 cites W2896480807 @default.
- W3193802004 cites W2909050129 @default.
- W3193802004 cites W2913268586 @default.
- W3193802004 cites W2950035043 @default.
- W3193802004 cites W2999151299 @default.
- W3193802004 cites W3110681087 @default.
- W3193802004 cites W3153933050 @default.
- W3193802004 cites W4211175431 @default.
- W3193802004 doi "https://doi.org/10.1111/all.15057" @default.
- W3193802004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34402091" @default.
- W3193802004 hasPublicationYear "2021" @default.
- W3193802004 type Work @default.
- W3193802004 sameAs 3193802004 @default.
- W3193802004 citedByCount "6" @default.
- W3193802004 countsByYear W31938020042022 @default.
- W3193802004 countsByYear W31938020042023 @default.
- W3193802004 crossrefType "journal-article" @default.
- W3193802004 hasAuthorship W3193802004A5010869573 @default.
- W3193802004 hasAuthorship W3193802004A5012874527 @default.
- W3193802004 hasAuthorship W3193802004A5013443180 @default.
- W3193802004 hasAuthorship W3193802004A5016086834 @default.
- W3193802004 hasAuthorship W3193802004A5016886169 @default.
- W3193802004 hasAuthorship W3193802004A5022822906 @default.
- W3193802004 hasAuthorship W3193802004A5026587210 @default.
- W3193802004 hasAuthorship W3193802004A5028027722 @default.
- W3193802004 hasAuthorship W3193802004A5033477948 @default.
- W3193802004 hasAuthorship W3193802004A5037426265 @default.
- W3193802004 hasAuthorship W3193802004A5044502423 @default.
- W3193802004 hasAuthorship W3193802004A5044756754 @default.
- W3193802004 hasAuthorship W3193802004A5046225422 @default.
- W3193802004 hasAuthorship W3193802004A5053231538 @default.
- W3193802004 hasAuthorship W3193802004A5055404517 @default.
- W3193802004 hasAuthorship W3193802004A5066775767 @default.
- W3193802004 hasAuthorship W3193802004A5068436726 @default.
- W3193802004 hasAuthorship W3193802004A5072486592 @default.
- W3193802004 hasAuthorship W3193802004A5073309319 @default.
- W3193802004 hasAuthorship W3193802004A5073531170 @default.