Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193805909> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W3193805909 endingPage "29" @default.
- W3193805909 startingPage "1" @default.
- W3193805909 abstract "Vanadium toxicity is a globally recognized threat to the reproductive health of man and animal. However the mechanism of vanadium-induced damage to the testicular and adrenocortical tissues is not fully characterized. It was hypothesized that prostaglandins may partially mediate the inflammatory response to vanadate damage. In this study prostaglandin (PG) mediated effects of vanadate on testicular and adrenocortical functions was substantiated by using indomethacin to block prostaglandin synthesis. Significant inhibition of spermatogenesis, decreased serum level of testosterone and gonadotropins in the vanadium-exposed group of rats indicated the damaging effects of vanadium-induced reactive oxygen species. This was also reflected in the appreciable increase in testicular lipid peroxidation (LPO) level and decline in the activities of steroidogenic and antioxidant enzymes. Histopathological studies revealed regressive and degenerative changes in testis. However, inhibition of cyclooxygenase activity by indomethacin increased steroid hormone production, gonadotropin level, elevated the specific activities of enzymes and decreased LPO level in rat testis exposed to vanadium. Vanadium also caused prostaglandin mediated adrenocortical hyperactivity, as inhibition of PG synthesis abolished these adrenal responses to vanadium. The studies showed that vanadium toxicity is directly linked to stimulation of prostaglandin synthesis. Therefore, indomethacin can be a good prospect to alleviate vanadium induced male infertility." @default.
- W3193805909 created "2021-08-30" @default.
- W3193805909 creator A5015593138 @default.
- W3193805909 creator A5022196586 @default.
- W3193805909 date "2021-08-25" @default.
- W3193805909 modified "2023-09-23" @default.
- W3193805909 title "Protective effect of Indomethacin on Vanadium-Induced Adrenocortical and Testicular damages in Rat" @default.
- W3193805909 cites W1528655921 @default.
- W3193805909 cites W1563253916 @default.
- W3193805909 cites W1590457525 @default.
- W3193805909 cites W1590512020 @default.
- W3193805909 cites W1775749144 @default.
- W3193805909 cites W1973337372 @default.
- W3193805909 cites W1983841618 @default.
- W3193805909 cites W1990666162 @default.
- W3193805909 cites W1992779501 @default.
- W3193805909 cites W1994265035 @default.
- W3193805909 cites W1996328827 @default.
- W3193805909 cites W2001009478 @default.
- W3193805909 cites W2016759352 @default.
- W3193805909 cites W2027794920 @default.
- W3193805909 cites W2055495362 @default.
- W3193805909 cites W2060194897 @default.
- W3193805909 cites W2063906821 @default.
- W3193805909 cites W2067782375 @default.
- W3193805909 cites W2072259978 @default.
- W3193805909 cites W2098030463 @default.
- W3193805909 cites W2151412059 @default.
- W3193805909 cites W2157267052 @default.
- W3193805909 cites W2166596095 @default.
- W3193805909 cites W2271956175 @default.
- W3193805909 cites W2331882494 @default.
- W3193805909 cites W2409305458 @default.
- W3193805909 cites W2416791589 @default.
- W3193805909 cites W2554771822 @default.
- W3193805909 cites W2590332667 @default.
- W3193805909 cites W2760499968 @default.
- W3193805909 cites W2999276776 @default.
- W3193805909 cites W3089327476 @default.
- W3193805909 cites W4205407119 @default.
- W3193805909 doi "https://doi.org/10.1080/15376516.2021.1973169" @default.
- W3193805909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34431458" @default.
- W3193805909 hasPublicationYear "2021" @default.
- W3193805909 type Work @default.
- W3193805909 sameAs 3193805909 @default.
- W3193805909 citedByCount "0" @default.
- W3193805909 crossrefType "journal-article" @default.
- W3193805909 hasAuthorship W3193805909A5015593138 @default.
- W3193805909 hasAuthorship W3193805909A5022196586 @default.
- W3193805909 hasConcept C126322002 @default.
- W3193805909 hasConcept C134018914 @default.
- W3193805909 hasConcept C179104552 @default.
- W3193805909 hasConcept C185592680 @default.
- W3193805909 hasConcept C2776151105 @default.
- W3193805909 hasConcept C2777956040 @default.
- W3193805909 hasConcept C2780664492 @default.
- W3193805909 hasConcept C2780829032 @default.
- W3193805909 hasConcept C2781116636 @default.
- W3193805909 hasConcept C29730261 @default.
- W3193805909 hasConcept C504678139 @default.
- W3193805909 hasConcept C55493867 @default.
- W3193805909 hasConcept C71924100 @default.
- W3193805909 hasConcept C86803240 @default.
- W3193805909 hasConcept C99432707 @default.
- W3193805909 hasConceptScore W3193805909C126322002 @default.
- W3193805909 hasConceptScore W3193805909C134018914 @default.
- W3193805909 hasConceptScore W3193805909C179104552 @default.
- W3193805909 hasConceptScore W3193805909C185592680 @default.
- W3193805909 hasConceptScore W3193805909C2776151105 @default.
- W3193805909 hasConceptScore W3193805909C2777956040 @default.
- W3193805909 hasConceptScore W3193805909C2780664492 @default.
- W3193805909 hasConceptScore W3193805909C2780829032 @default.
- W3193805909 hasConceptScore W3193805909C2781116636 @default.
- W3193805909 hasConceptScore W3193805909C29730261 @default.
- W3193805909 hasConceptScore W3193805909C504678139 @default.
- W3193805909 hasConceptScore W3193805909C55493867 @default.
- W3193805909 hasConceptScore W3193805909C71924100 @default.
- W3193805909 hasConceptScore W3193805909C86803240 @default.
- W3193805909 hasConceptScore W3193805909C99432707 @default.
- W3193805909 hasLocation W31938059091 @default.
- W3193805909 hasLocation W31938059092 @default.
- W3193805909 hasOpenAccess W3193805909 @default.
- W3193805909 hasPrimaryLocation W31938059091 @default.
- W3193805909 hasRelatedWork W1994737030 @default.
- W3193805909 hasRelatedWork W1997229407 @default.
- W3193805909 hasRelatedWork W2003789953 @default.
- W3193805909 hasRelatedWork W2006844127 @default.
- W3193805909 hasRelatedWork W2016034363 @default.
- W3193805909 hasRelatedWork W2028620758 @default.
- W3193805909 hasRelatedWork W2030859874 @default.
- W3193805909 hasRelatedWork W2056100207 @default.
- W3193805909 hasRelatedWork W3193805909 @default.
- W3193805909 hasRelatedWork W347809129 @default.
- W3193805909 isParatext "false" @default.
- W3193805909 isRetracted "false" @default.
- W3193805909 magId "3193805909" @default.
- W3193805909 workType "article" @default.