FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193817084> ?p ?o ?g. }

• W3193817084 abstract "Abstract Emerging evidence suggests that immune cells not only communicate with each other through cytokines, chemokines, and cell surface receptors, but also by releasing small membranous structures known as extracellular vesicles (EVs). EVs carry a variety of different molecules that can be taken up by recipient cells. Parasitic worms are well known for their immunomodulatory properties, but whether they can affect immune responses by altering EV‐driven communication between host immune cells remains unclear. Here we provide evidence that stimulation of bone marrow‐derived macrophages (BMDMs) with soluble products of Trichuris suis (TSPs), leads to the release of EVs with anti‐inflammatory properties. Specifically, we found that EVs from TSP‐pulsed BMDMs, but not those from unstimulated BMDMs can suppress TNFα and IL‐6 release in LPS‐stimulated BMDMs and BMDCs. However, no polarization toward M1 or M2 was observed in macrophages exposed to EVs. Moreover, EVs enhanced reactive oxygen species (ROS) production in the exposed BMDMs, which was associated with a deregulated redox homeostasis as revealed by pathway analysis of transcriptomic data. Proteomic analysis identified cytochrome p450 (CYP450) as a potential source of ROS in EVs from TSP‐pulsed BMDMs. Finally, pharmacological inhibition of CYP450 activity could suppress ROS production in those BMDMs. In summary, we find that TSPs can modulate immune responses not only via direct interactions but also indirectly by eliciting the release of EVs from BMDMs that exert anti‐inflammatory effects on recipient cells." @default.
• W3193817084 created "2021-08-30" @default.
• W3193817084 creator A5018229472 @default.
• W3193817084 creator A5029293059 @default.
• W3193817084 creator A5048458502 @default.
• W3193817084 creator A5056528869 @default.
• W3193817084 creator A5060321719 @default.
• W3193817084 creator A5082088297 @default.
• W3193817084 creator A5082344657 @default.
• W3193817084 date "2021-08-01" @default.
• W3193817084 modified "2023-09-24" @default.
• W3193817084 title "Parasite worm antigens instruct macrophages to release immunoregulatory extracellular vesicles" @default.
• W3193817084 cites W1653521872 @default.
• W3193817084 cites W1849790851 @default.
• W3193817084 cites W1974209230 @default.
• W3193817084 cites W2003153465 @default.
• W3193817084 cites W2003343932 @default.
• W3193817084 cites W2015387324 @default.
• W3193817084 cites W2035650290 @default.
• W3193817084 cites W2042183116 @default.
• W3193817084 cites W2054170914 @default.
• W3193817084 cites W2055348159 @default.
• W3193817084 cites W2073608230 @default.
• W3193817084 cites W2096781102 @default.
• W3193817084 cites W2102619095 @default.
• W3193817084 cites W2121501859 @default.
• W3193817084 cites W2122635106 @default.
• W3193817084 cites W2139966787 @default.
• W3193817084 cites W2141985921 @default.
• W3193817084 cites W2146254468 @default.
• W3193817084 cites W2157622382 @default.
• W3193817084 cites W2220643393 @default.
• W3193817084 cites W2296538017 @default.
• W3193817084 cites W2338485512 @default.
• W3193817084 cites W2342275754 @default.
• W3193817084 cites W2468925656 @default.
• W3193817084 cites W2548555233 @default.
• W3193817084 cites W2608697804 @default.
• W3193817084 cites W2756078572 @default.
• W3193817084 cites W2756112558 @default.
• W3193817084 cites W2791769931 @default.
• W3193817084 cites W2894850520 @default.
• W3193817084 cites W2900251986 @default.
• W3193817084 cites W2900756811 @default.
• W3193817084 cites W2925523925 @default.
• W3193817084 cites W2941038794 @default.
• W3193817084 cites W2941190868 @default.
• W3193817084 cites W2956865263 @default.
• W3193817084 cites W2965218497 @default.
• W3193817084 cites W2974232556 @default.
• W3193817084 cites W2992985923 @default.
• W3193817084 cites W3011359130 @default.
• W3193817084 cites W3020389314 @default.
• W3193817084 cites W3023083210 @default.
• W3193817084 cites W3027950201 @default.
• W3193817084 cites W3028847828 @default.
• W3193817084 cites W3042217302 @default.
• W3193817084 cites W3096447928 @default.
• W3193817084 cites W3110334671 @default.
• W3193817084 cites W3116176019 @default.
• W3193817084 doi "https://doi.org/10.1002/jev2.12131" @default.
• W3193817084 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8365858" @default.
• W3193817084 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34429858" @default.
• W3193817084 hasPublicationYear "2021" @default.
• W3193817084 type Work @default.
• W3193817084 sameAs 3193817084 @default.
• W3193817084 citedByCount "6" @default.
• W3193817084 countsByYear W31938170842021 @default.
• W3193817084 countsByYear W31938170842022 @default.
• W3193817084 countsByYear W31938170842023 @default.
• W3193817084 crossrefType "journal-article" @default.
• W3193817084 hasAuthorship W3193817084A5018229472 @default.
• W3193817084 hasAuthorship W3193817084A5029293059 @default.
• W3193817084 hasAuthorship W3193817084A5048458502 @default.
• W3193817084 hasAuthorship W3193817084A5056528869 @default.
• W3193817084 hasAuthorship W3193817084A5060321719 @default.
• W3193817084 hasAuthorship W3193817084A5082088297 @default.
• W3193817084 hasAuthorship W3193817084A5082344657 @default.
• W3193817084 hasBestOaLocation W31938170841 @default.
• W3193817084 hasConcept C104317684 @default.
• W3193817084 hasConcept C13373296 @default.
• W3193817084 hasConcept C145059251 @default.
• W3193817084 hasConcept C185592680 @default.
• W3193817084 hasConcept C203014093 @default.
• W3193817084 hasConcept C20518536 @default.
• W3193817084 hasConcept C2776914184 @default.
• W3193817084 hasConcept C28406088 @default.
• W3193817084 hasConcept C55493867 @default.
• W3193817084 hasConcept C86803240 @default.
• W3193817084 hasConcept C8891405 @default.
• W3193817084 hasConcept C95444343 @default.
• W3193817084 hasConceptScore W3193817084C104317684 @default.
• W3193817084 hasConceptScore W3193817084C13373296 @default.
• W3193817084 hasConceptScore W3193817084C145059251 @default.
• W3193817084 hasConceptScore W3193817084C185592680 @default.
• W3193817084 hasConceptScore W3193817084C203014093 @default.
• W3193817084 hasConceptScore W3193817084C20518536 @default.
• W3193817084 hasConceptScore W3193817084C2776914184 @default.
• W3193817084 hasConceptScore W3193817084C28406088 @default.
• W3193817084 hasConceptScore W3193817084C55493867 @default.

• next