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- W3193825247 endingPage "8261" @default.
- W3193825247 startingPage "8249" @default.
- W3193825247 abstract "Abstract The 3‐halo‐4,5‐dihydroisoxazole moiety is an interesting emerging feature in medicinal and organic chemistry fields. The properties of this nucleus are intimately correlated with the nature of the halogen substituent, ranging from inertness to instability. In between, the 3‐bromo‐Δ 2 ‐isoxazoline scaffold stands out as a handleable and easily affordable electrophilic warhead, able to react with nucleophilic active sites of different enzymes, determining inhibitory effects. However, the importance of 3‐bromo‐Δ 2 ‐isoxazolines does not rely only upon their biological activity. In fact, they are valuable synthetic intermediates, presenting a peculiar reactivity spectrum that allows access to useful chemical functions, ranging from variously decorated dihydroisoxazoles to β‐hydroxynitriles, β‐hydroxyesters, and γ‐hydroxyamines. The synthesis of 3‐bromo‐Δ 2 ‐isoxazolines is predominantly based on the 1,3‐dipolar cycloaddition, a pericyclic reaction accompanied by a remarkable regio‐ and stereo‐selectivity. Thus, this intermediate lends itself especially well to the production of complex molecules with regio‐ and stereo‐chemical requirements." @default.
- W3193825247 created "2021-08-30" @default.
- W3193825247 creator A5034291688 @default.
- W3193825247 creator A5072080476 @default.
- W3193825247 date "2021-08-23" @default.
- W3193825247 modified "2023-10-13" @default.
- W3193825247 title "Synthesis and Reactivity of 3‐Halo‐4,5‐dihydroisoxazoles: An Overview" @default.
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