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- W3193837692 endingPage "306" @default.
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- W3193837692 abstract "The composition of the gut microbiome is greatly influenced by nutrition and dietary alterations which can also induce large temporary microbial shifts. However, the molecular mechanisms that promote these changes remain to be determined. Species of the family Lactobacillaceae and Bacillus species are genetically manipulatable bacteria that are naturally found in the human gastrointestinal (GI) tract and are often considered models of beneficial microbiota. Here, we identify specific conserved molecular pathways that play a key role in host colonization by beneficial members of the microbiota. In particular, we highlight three pathways important to the success of lactic acid bacteria (LAB) in the GI tract: glycolysis and fermentation, microbial communication via membrane vesicles, and condition-dependent antibiotic production. We elaborate on how the understanding of these circuits can lead to the development of novel therapeutic approaches to combat GI tract infections." @default.
- W3193837692 created "2021-08-30" @default.
- W3193837692 creator A5000333348 @default.
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- W3193837692 creator A5043877539 @default.
- W3193837692 creator A5081627166 @default.
- W3193837692 creator A5087026739 @default.
- W3193837692 date "2022-03-01" @default.
- W3193837692 modified "2023-10-11" @default.
- W3193837692 title "Molecular genetics for probiotic engineering: dissecting lactic acid bacteria" @default.
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