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• W3193842907 abstract "Objectives: Prior literature suggests that Black individuals exhibit a higher prevalence of aggressive molecular features in different cancers including endometrial cancers. Blacks may also have more defects in homologous recombination deficiency (HRD). It is currently unclear if the difference in somatic mutations in HRD genes between Blacks and Whites extends to other races and varies by cancer site. This study evaluated racial disparities in somatic mutations in HRD genes in ovarian, endometrial, and cervical cancer. Methods: Data were obtained from The Cancer Genome Atlas (TCGA). Somatic mutations in genes associated with HRD including BRCA-1, BRCA-2, PTEN, CDK12, and RAD51C were acquired for the women with invasive ovarian, uterine, or cervical cancer. Race was categorized as White, Black, Asian, American-Indian, Pacific Islander, or Unknown. Chi-square was used to compare differences in the proportion of mutations between racial groups. Results: Conclusions: The observed racial differences in the distribution of somatic mutations in HRD across gynecologic malignancies merits further investigation to tailor treatment selection to target these defects. Prior literature suggests that Black individuals exhibit a higher prevalence of aggressive molecular features in different cancers including endometrial cancers. Blacks may also have more defects in homologous recombination deficiency (HRD). It is currently unclear if the difference in somatic mutations in HRD genes between Blacks and Whites extends to other races and varies by cancer site. This study evaluated racial disparities in somatic mutations in HRD genes in ovarian, endometrial, and cervical cancer. Data were obtained from The Cancer Genome Atlas (TCGA). Somatic mutations in genes associated with HRD including BRCA-1, BRCA-2, PTEN, CDK12, and RAD51C were acquired for the women with invasive ovarian, uterine, or cervical cancer. Race was categorized as White, Black, Asian, American-Indian, Pacific Islander, or Unknown. Chi-square was used to compare differences in the proportion of mutations between racial groups. The observed racial differences in the distribution of somatic mutations in HRD across gynecologic malignancies merits further investigation to tailor treatment selection to target these defects." @default.
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• W3193842907 date "2021-08-01" @default.
• W3193842907 modified "2023-10-16" @default.
• W3193842907 title "Racial disparities in prevalence of homologous recombination deficiency in ovarian, uterine, and cervical cancer tumors" @default.
• W3193842907 doi "https://doi.org/10.1016/s0090-8258(21)00731-9" @default.
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