Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193855379> ?p ?o ?g. }
- W3193855379 endingPage "112021" @default.
- W3193855379 startingPage "112021" @default.
- W3193855379 abstract "Valproic acid (VPA) is an approved drug for managing epileptic seizures, bipolar disorders, and migraine. VPA has been shown to elevate the level of gamma-aminobutyric acid (GABA) in the brain through competitive inhibition of GABA transaminase, thus promoting the availability of synaptic GABA and facilitating GABA-mediated responses. VPA, which is a small chain of fatty acids, prevents histone deacetylases (HDACs). HDACs play a crucial role in chromatin remodeling and gene expression through posttranslational changes of chromatin-associated histones. Recent studies reported a possible effect of VPA against particular types of cancers. This effect was partially attributed to its role in regulating epigenetic modifications through the inhibition of HDACs, which affect the expression of genes associated with cell cycle control, cellular differentiation, and apoptosis. In this review, we summarize the current information on the actions of VPA in diseases such as diabetes mellitus, kidney disorders, neurodegenerative diseases, muscular dystrophy, and cardiovascular disorders." @default.
- W3193855379 created "2021-08-30" @default.
- W3193855379 creator A5001934184 @default.
- W3193855379 creator A5011263734 @default.
- W3193855379 creator A5038108344 @default.
- W3193855379 creator A5064550023 @default.
- W3193855379 creator A5085320315 @default.
- W3193855379 creator A5091596289 @default.
- W3193855379 date "2021-10-01" @default.
- W3193855379 modified "2023-10-16" @default.
- W3193855379 title "Hidden pharmacological activities of valproic acid: A new insight" @default.
- W3193855379 cites W125678881 @default.
- W3193855379 cites W1593901930 @default.
- W3193855379 cites W1600829492 @default.
- W3193855379 cites W1605265126 @default.
- W3193855379 cites W1783136405 @default.
- W3193855379 cites W1868426883 @default.
- W3193855379 cites W1965187459 @default.
- W3193855379 cites W1965357422 @default.
- W3193855379 cites W1965500568 @default.
- W3193855379 cites W1969526225 @default.
- W3193855379 cites W1970765132 @default.
- W3193855379 cites W1971315369 @default.
- W3193855379 cites W1971980926 @default.
- W3193855379 cites W1975236792 @default.
- W3193855379 cites W1976508783 @default.
- W3193855379 cites W1995770917 @default.
- W3193855379 cites W1996978408 @default.
- W3193855379 cites W1997425755 @default.
- W3193855379 cites W2000792793 @default.
- W3193855379 cites W2003429977 @default.
- W3193855379 cites W2003460922 @default.
- W3193855379 cites W2004143468 @default.
- W3193855379 cites W2006677458 @default.
- W3193855379 cites W2007302719 @default.
- W3193855379 cites W2007331931 @default.
- W3193855379 cites W2010847506 @default.
- W3193855379 cites W2011182034 @default.
- W3193855379 cites W2015538824 @default.
- W3193855379 cites W2026582458 @default.
- W3193855379 cites W2029993808 @default.
- W3193855379 cites W2037189426 @default.
- W3193855379 cites W2038524016 @default.
- W3193855379 cites W2043024635 @default.
- W3193855379 cites W2044389296 @default.
- W3193855379 cites W2046690065 @default.
- W3193855379 cites W2057438237 @default.
- W3193855379 cites W2062270769 @default.
- W3193855379 cites W206344101 @default.
- W3193855379 cites W2067510388 @default.
- W3193855379 cites W2071934663 @default.
- W3193855379 cites W2078901327 @default.
- W3193855379 cites W2089689396 @default.
- W3193855379 cites W2094128461 @default.
- W3193855379 cites W2094916309 @default.
- W3193855379 cites W2097145992 @default.
- W3193855379 cites W2098145833 @default.
- W3193855379 cites W2099414169 @default.
- W3193855379 cites W2101787540 @default.
- W3193855379 cites W2107204307 @default.
- W3193855379 cites W2119668354 @default.
- W3193855379 cites W2121056556 @default.
- W3193855379 cites W2129768414 @default.
- W3193855379 cites W2139771301 @default.
- W3193855379 cites W2140103101 @default.
- W3193855379 cites W2142534237 @default.
- W3193855379 cites W2142643067 @default.
- W3193855379 cites W2154164205 @default.
- W3193855379 cites W2154572495 @default.
- W3193855379 cites W2156645168 @default.
- W3193855379 cites W2167476293 @default.
- W3193855379 cites W2176676115 @default.
- W3193855379 cites W2178162721 @default.
- W3193855379 cites W2228444494 @default.
- W3193855379 cites W2289676561 @default.
- W3193855379 cites W2318410985 @default.
- W3193855379 cites W2341080253 @default.
- W3193855379 cites W2342628474 @default.
- W3193855379 cites W2343980063 @default.
- W3193855379 cites W2483618321 @default.
- W3193855379 cites W2524892586 @default.
- W3193855379 cites W2610690619 @default.
- W3193855379 cites W2736586232 @default.
- W3193855379 cites W2757849159 @default.
- W3193855379 cites W2770614732 @default.
- W3193855379 cites W2773844870 @default.
- W3193855379 cites W2790974502 @default.
- W3193855379 cites W2804899776 @default.
- W3193855379 cites W282915454 @default.
- W3193855379 cites W2888149084 @default.
- W3193855379 cites W2896871711 @default.
- W3193855379 cites W2901708026 @default.
- W3193855379 cites W2904770603 @default.
- W3193855379 cites W2905518901 @default.
- W3193855379 cites W2907931906 @default.
- W3193855379 cites W2912582226 @default.
- W3193855379 cites W2924894870 @default.
- W3193855379 cites W2930382649 @default.