FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193866712> ?p ?o ?g. }

• W3193866712 abstract "Enterotoxigenic Escherichia coli (ETEC) is one of the most common causes of acute traveler's diarrhea. Adhesins and enterotoxins constitute the major ETEC virulence traits. With the dramatic increase in antibiotic resistance, probiotics are considered a wholesome alternative to prevent or treat ETEC infections. Here, we examined the antimicrobial properties of the probiotic Saccharomyces cerevisiae CNCM I-3856 against ETEC H10407 pathogenesis upon co-administration in the TNO gastrointestinal Model (TIM-1), simulating the physicochemical and enzymatic conditions of the human upper digestive tract and preventive treatment in the Mucosal Simulator of the Human Intestinal Microbial Ecosystem (M-SHIME), integrating microbial populations of the ileum and ascending colon. Interindividual variability was assessed by separate M-SHIME experiments with microbiota from six human individuals. The probiotic did not affect ETEC survival along the digestive tract. However, ETEC pathogenicity was significantly reduced: enterotoxin encoding virulence genes were repressed, especially in the TIM-1 system, and a lower enterotoxin production was noted. M-SHIME experiments revealed that 18-days probiotic treatment stimulate the growth of Bifidobacterium and Lactobacillus in different gut regions (mucosal and luminal, ileum and ascending colon) while a stronger metabolic activity was noted in terms of short-chain fatty acids (acetate, propionate, and butyrate) and ethanol production. Moreover, the probiotic pre-treated microbiota displayed a higher robustness in composition following ETEC challenge compared to the control condition. We thus demonstrated the multi-inhibitory properties of the probiotic S. cerevisiae CNCM I-3856 against ETEC in the overall simulated human digestive tract, regardless of the inherent variability across individuals in the M-SHIME." @default.
• W3193866712 created "2021-08-30" @default.
• W3193866712 creator A5014069192 @default.
• W3193866712 creator A5030763941 @default.
• W3193866712 creator A5035835360 @default.
• W3193866712 creator A5051163655 @default.
• W3193866712 creator A5061859140 @default.
• W3193866712 creator A5065656130 @default.
• W3193866712 creator A5066627441 @default.
• W3193866712 creator A5074108324 @default.
• W3193866712 creator A5074588940 @default.
• W3193866712 creator A5074822308 @default.
• W3193866712 creator A5085325390 @default.
• W3193866712 date "2021-01-01" @default.
• W3193866712 modified "2023-10-16" @default.
• W3193866712 title "Multi-targeted properties of the probiotic <i>saccharomyces cerevisiae</i> CNCM I-3856 against enterotoxigenic <i>escherichia coli</i> (ETEC) H10407 pathogenesis across human gut models" @default.
• W3193866712 cites W1492535541 @default.
• W3193866712 cites W1493139521 @default.
• W3193866712 cites W1531467346 @default.
• W3193866712 cites W1868830645 @default.
• W3193866712 cites W1878193911 @default.
• W3193866712 cites W1908750686 @default.
• W3193866712 cites W1915524531 @default.
• W3193866712 cites W1951197670 @default.
• W3193866712 cites W1954285518 @default.
• W3193866712 cites W1971523165 @default.
• W3193866712 cites W2000156190 @default.
• W3193866712 cites W2000208662 @default.
• W3193866712 cites W2004014148 @default.
• W3193866712 cites W2005651177 @default.
• W3193866712 cites W2018397292 @default.
• W3193866712 cites W2020494261 @default.
• W3193866712 cites W2021385518 @default.
• W3193866712 cites W2028520715 @default.
• W3193866712 cites W2030118042 @default.
• W3193866712 cites W2036509718 @default.
• W3193866712 cites W2039021127 @default.
• W3193866712 cites W2055043387 @default.
• W3193866712 cites W2061187463 @default.
• W3193866712 cites W2078361971 @default.
• W3193866712 cites W2099881697 @default.
• W3193866712 cites W2102681583 @default.
• W3193866712 cites W2117457769 @default.
• W3193866712 cites W2122904426 @default.
• W3193866712 cites W2127577084 @default.
• W3193866712 cites W2133843660 @default.
• W3193866712 cites W2136879569 @default.
• W3193866712 cites W2146725828 @default.
• W3193866712 cites W2151350595 @default.
• W3193866712 cites W2152885278 @default.
• W3193866712 cites W2154199205 @default.
• W3193866712 cites W2156619206 @default.
• W3193866712 cites W2172059146 @default.
• W3193866712 cites W2175175520 @default.
• W3193866712 cites W2179438025 @default.
• W3193866712 cites W2259127554 @default.
• W3193866712 cites W2274927794 @default.
• W3193866712 cites W2282896971 @default.
• W3193866712 cites W2286660139 @default.
• W3193866712 cites W2292760617 @default.
• W3193866712 cites W2297612738 @default.
• W3193866712 cites W2340538846 @default.
• W3193866712 cites W2395426847 @default.
• W3193866712 cites W2460075091 @default.
• W3193866712 cites W2464484550 @default.
• W3193866712 cites W2470512478 @default.
• W3193866712 cites W2504821778 @default.
• W3193866712 cites W2554992360 @default.
• W3193866712 cites W2563186829 @default.
• W3193866712 cites W2608018575 @default.
• W3193866712 cites W2618347416 @default.
• W3193866712 cites W2625874610 @default.
• W3193866712 cites W2759742133 @default.
• W3193866712 cites W2766840884 @default.
• W3193866712 cites W2777248989 @default.
• W3193866712 cites W2788566624 @default.
• W3193866712 cites W2790138328 @default.
• W3193866712 cites W2794726745 @default.
• W3193866712 cites W2801213637 @default.
• W3193866712 cites W2803748133 @default.
• W3193866712 cites W2811455672 @default.
• W3193866712 cites W2884679414 @default.
• W3193866712 cites W2919932445 @default.
• W3193866712 cites W2943320595 @default.
• W3193866712 cites W2954124338 @default.
• W3193866712 cites W3091358887 @default.
• W3193866712 cites W3093199286 @default.
• W3193866712 cites W3135229876 @default.
• W3193866712 cites W836389256 @default.
• W3193866712 cites W838513727 @default.
• W3193866712 cites W982662479 @default.
• W3193866712 doi "https://doi.org/10.1080/19490976.2021.1953246" @default.
• W3193866712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8405159" @default.
• W3193866712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34432600" @default.
• W3193866712 hasPublicationYear "2021" @default.
• W3193866712 type Work @default.
• W3193866712 sameAs 3193866712 @default.
• W3193866712 citedByCount "11" @default.
• W3193866712 countsByYear W31938667122022 @default.
• W3193866712 countsByYear W31938667122023 @default.

• next