FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193869063> ?p ?o ?g. }

• W3193869063 endingPage "282" @default.
• W3193869063 startingPage "261" @default.
• W3193869063 abstract "Age is the only one non-modifiable risk of cerebral ischemia. Advances in stroke medicine and the adaptation to stroke risk factors and comorbidities were successful in decreasing stroke incidence and increasing the number of stroke survivors in western societies. Comorbidities aggravate the outcome after cerebral ischemia. However, due to the increased in the number of elderly, the incidence of stroke has increased again paralleled by an increase in the number of stroke survivors, many with severe disabilities, that has led to an increased economic and social burden in society. Animal models of stroke often ignore age and comorbidities frequently associated with senescence. This might explain why drugs working nicely in animal models fail to show efficacy in stroke survivors. Since stroke afflicts mostly the elderly comorbid patients, it is highly desirable to test the efficacy of stroke therapies in an appropriate animal stroke model. In this review, we make parallels between animal models of stroke and clinical data and summarize the impact of aging and age-related comorbidities on the efficacy of various therapies and stroke outcome. We conclude that the unsuccessful bench-to-bedside translation of therapies that showed efficacy in young animal models, to aged stroke comorbid patients, is, most likely, due to the negative impact of comorbidities and advanced age on the efficacy of restorative therapies." @default.
• W3193869063 created "2021-08-30" @default.
• W3193869063 creator A5068091656 @default.
• W3193869063 creator A5075498671 @default.
• W3193869063 creator A5088358870 @default.
• W3193869063 date "2021-01-01" @default.
• W3193869063 modified "2023-09-26" @default.
• W3193869063 title "The Impact of Aging and Age-Related Comorbidities on Stroke Outcome in Animal Models and Humans" @default.
• W3193869063 cites W1588971641 @default.
• W3193869063 cites W1765146139 @default.
• W3193869063 cites W1814275835 @default.
• W3193869063 cites W1904343043 @default.
• W3193869063 cites W1912243307 @default.
• W3193869063 cites W1965575569 @default.
• W3193869063 cites W1967696347 @default.
• W3193869063 cites W1967751896 @default.
• W3193869063 cites W1968335235 @default.
• W3193869063 cites W1968493125 @default.
• W3193869063 cites W1969142228 @default.
• W3193869063 cites W1971065585 @default.
• W3193869063 cites W1972042674 @default.
• W3193869063 cites W1973041901 @default.
• W3193869063 cites W1974788844 @default.
• W3193869063 cites W1978601767 @default.
• W3193869063 cites W1982882278 @default.
• W3193869063 cites W1996035323 @default.
• W3193869063 cites W1997801266 @default.
• W3193869063 cites W1998463679 @default.
• W3193869063 cites W2000281669 @default.
• W3193869063 cites W2002937314 @default.
• W3193869063 cites W2002956393 @default.
• W3193869063 cites W2004709636 @default.
• W3193869063 cites W2005369912 @default.
• W3193869063 cites W2005529290 @default.
• W3193869063 cites W2005568095 @default.
• W3193869063 cites W2005847735 @default.
• W3193869063 cites W2008108982 @default.
• W3193869063 cites W2012154384 @default.
• W3193869063 cites W2013303926 @default.
• W3193869063 cites W2014006430 @default.
• W3193869063 cites W2017584345 @default.
• W3193869063 cites W2021461511 @default.
• W3193869063 cites W2022067316 @default.
• W3193869063 cites W2022829049 @default.
• W3193869063 cites W2022972042 @default.
• W3193869063 cites W2025706629 @default.
• W3193869063 cites W2026257843 @default.
• W3193869063 cites W2026890448 @default.
• W3193869063 cites W2028321082 @default.
• W3193869063 cites W2028621484 @default.
• W3193869063 cites W2033614725 @default.
• W3193869063 cites W2034064412 @default.
• W3193869063 cites W2036914347 @default.
• W3193869063 cites W2041265697 @default.
• W3193869063 cites W2042880990 @default.
• W3193869063 cites W2045314069 @default.
• W3193869063 cites W2045366950 @default.
• W3193869063 cites W2045757887 @default.
• W3193869063 cites W2049680139 @default.
• W3193869063 cites W2051512233 @default.
• W3193869063 cites W2052874229 @default.
• W3193869063 cites W2053196806 @default.
• W3193869063 cites W2053235800 @default.
• W3193869063 cites W2055640533 @default.
• W3193869063 cites W2056068526 @default.
• W3193869063 cites W2056833572 @default.
• W3193869063 cites W2057785271 @default.
• W3193869063 cites W2062247228 @default.
• W3193869063 cites W2065954434 @default.
• W3193869063 cites W2068112437 @default.
• W3193869063 cites W2069028726 @default.
• W3193869063 cites W2073570862 @default.
• W3193869063 cites W2074693648 @default.
• W3193869063 cites W2075317738 @default.
• W3193869063 cites W2076428954 @default.
• W3193869063 cites W2076856953 @default.
• W3193869063 cites W2077033935 @default.
• W3193869063 cites W2077261742 @default.
• W3193869063 cites W2078746887 @default.
• W3193869063 cites W2078755005 @default.
• W3193869063 cites W2079180172 @default.
• W3193869063 cites W2084877050 @default.
• W3193869063 cites W2086373048 @default.
• W3193869063 cites W2090644196 @default.
• W3193869063 cites W2094145636 @default.
• W3193869063 cites W2095234263 @default.
• W3193869063 cites W2096666003 @default.
• W3193869063 cites W2097470222 @default.
• W3193869063 cites W2097480777 @default.
• W3193869063 cites W2099837480 @default.
• W3193869063 cites W2101688816 @default.
• W3193869063 cites W2102462389 @default.
• W3193869063 cites W2104608685 @default.
• W3193869063 cites W2104673339 @default.
• W3193869063 cites W2108887402 @default.
• W3193869063 cites W2109542855 @default.
• W3193869063 cites W2109737326 @default.
• W3193869063 cites W2112095855 @default.

• next