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- W3193875008 abstract "Abstract In Drosophila , direction-selective neurons implement a mechanism of motion computation similar to cortical neurons, using contrast-opponent receptive fields with ON and OFF subfields. It is not clear how the presynaptic circuitry of direction-selective neurons in the OFF pathway supports this computation if all major inputs are OFF-rectified neurons. Here, we reveal the biological substrate for motion computation in the OFF pathway. Three interneurons, Tm2, Tm9 and CT1, provide information about ON stimuli to the OFF direction-selective neuron T5 across its receptive field, supporting a contrast-opponent receptive field organization. Consistent with its prominent role in motion detection, variability in Tm9 receptive field properties transfers to T5, and calcium decrements in Tm9 in response to ON stimuli persist across behavioral states, while spatial tuning is sharpened by active behavior. Together, our work shows how a key neuronal computation is implemented by its constituent neuronal circuit elements to ensure direction selectivity." @default.
- W3193875008 created "2021-08-30" @default.
- W3193875008 creator A5027898696 @default.
- W3193875008 creator A5060257317 @default.
- W3193875008 date "2021-08-17" @default.
- W3193875008 modified "2023-10-03" @default.
- W3193875008 title "The physiological basis for contrast opponency in motion computation in Drosophila" @default.
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- W3193875008 doi "https://doi.org/10.1038/s41467-021-24986-w" @default.
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