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- W3193920132 abstract "Iripin-5 is the main Ixodes ricinus salivary serpin, which acts as a modulator of host defence mechanisms by impairing neutrophil migration, suppressing nitric oxide production by macrophages and altering complement functions. Iripin-5 influences host immunity and shows high expression in the salivary glands. Here, the crystal structure of Iripin-5 in the most thermodynamically stable state of serpins is described. In the reactive-centre loop, the main substrate-recognition site of Iripin-5 is likely to be represented by Arg342, which implies the targeting of trypsin-like proteases. Furthermore, a computational structural analysis of selected Iripin-5–protease complexes together with interface analysis revealed the most probable residues of Iripin-5 involved in complex formation." @default.
- W3193920132 created "2021-08-30" @default.
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- W3193920132 date "2021-08-23" @default.
- W3193920132 modified "2023-10-18" @default.
- W3193920132 title "Structural and biochemical characterization of the novel serpin Iripin-5 from <i>Ixodes ricinus</i>" @default.
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- W3193920132 doi "https://doi.org/10.1107/s2059798321007920" @default.
- W3193920132 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8573701" @default.
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- W3193920132 hasPublicationYear "2021" @default.
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