FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3193969085> ?p ?o ?g. }

• W3193969085 endingPage "2466" @default.
• W3193969085 startingPage "2466" @default.
• W3193969085 abstract "Feline chronic gingivostomatitis (FCGS) is a pathology with a complicated therapeutic approach and with a prevalence between 0.7 and 12%. Although the etiology of the disease is diverse, feline calicivirus infection is known to be a predisposing factor. To date, the available treatment helps in controlling the disease, but cannot always provide a cure, which leads to a high percentage of refractory animals. Mesenchymal stem cells (MSCs) play a pivotal role in the homeostasis and reparation of different tissues and have the ability to modulate the immune system responses. This ability is, in part, due to the capacity of exosomes to play a part in intercellular cell communication. However, the precise role of MSC-derived exosomes and their alterations in immunocompromised pathologies remains unknown, especially in veterinary patients. The goal of this work was to analyze the proteomic profile of feline adipose tissue-derived MSCs (fAd-MSCs) from calicivirus-positive FCGS patients, and to detect possible modifications of the exosomal cargo, to gain better knowledge of the disease’s etiopathogenesis. Using high-resolution mass spectrometry and functional enrichment analysis with Gene Ontology, exosomes isolated from the fAd-MSCs of five healthy cats and five calicivirus-positive FCGS patients, were pooled and compared. The results showed that the fAd-MSCs from cats suffering from FCGS not only had a higher exosome production, but also their exosomes showed significant alterations in their proteomic profile. Eight proteins were exclusively found in the exosomes from the FCGS group, and five proteins could only be found in the exosomes from the healthy cats. When comparing the exosomal cargo between the two groups, significant upregulation of 17 and downregulation of 13 proteins were detected in the FCGS group compared to the control group. These findings shed light on new perspectives on the roles of MSCs and their relation to this disease, which may help in identifying new therapeutic targets and selecting specific biomarkers." @default.
• W3193969085 created "2021-08-30" @default.
• W3193969085 creator A5002934621 @default.
• W3193969085 creator A5008116526 @default.
• W3193969085 creator A5024461534 @default.
• W3193969085 creator A5034849565 @default.
• W3193969085 creator A5061205644 @default.
• W3193969085 creator A5064643672 @default.
• W3193969085 creator A5091663866 @default.
• W3193969085 date "2021-08-23" @default.
• W3193969085 modified "2023-10-16" @default.
• W3193969085 title "Altered Proteomic Profile of Adipose Tissue-Derived Mesenchymal Stem Cell Exosomes from Cats with Severe Chronic Gingivostomatitis" @default.
• W3193969085 cites W130589473 @default.
• W3193969085 cites W1929307843 @default.
• W3193969085 cites W1973242875 @default.
• W3193969085 cites W1977692564 @default.
• W3193969085 cites W1992723596 @default.
• W3193969085 cites W1999009548 @default.
• W3193969085 cites W2003805305 @default.
• W3193969085 cites W2019081320 @default.
• W3193969085 cites W2025371271 @default.
• W3193969085 cites W2035040282 @default.
• W3193969085 cites W2037165989 @default.
• W3193969085 cites W2053943711 @default.
• W3193969085 cites W2068715852 @default.
• W3193969085 cites W2088964957 @default.
• W3193969085 cites W2102971263 @default.
• W3193969085 cites W2151213561 @default.
• W3193969085 cites W2159401023 @default.
• W3193969085 cites W2166166580 @default.
• W3193969085 cites W2175410088 @default.
• W3193969085 cites W2207291742 @default.
• W3193969085 cites W2208981157 @default.
• W3193969085 cites W2287991835 @default.
• W3193969085 cites W2315617025 @default.
• W3193969085 cites W2334703889 @default.
• W3193969085 cites W2337861353 @default.
• W3193969085 cites W2418191755 @default.
• W3193969085 cites W2442498086 @default.
• W3193969085 cites W2512730605 @default.
• W3193969085 cites W2513368489 @default.
• W3193969085 cites W2519925888 @default.
• W3193969085 cites W2586056853 @default.
• W3193969085 cites W2587850954 @default.
• W3193969085 cites W2605311381 @default.
• W3193969085 cites W2624839860 @default.
• W3193969085 cites W2735330142 @default.
• W3193969085 cites W2771557629 @default.
• W3193969085 cites W2774432460 @default.
• W3193969085 cites W2794217634 @default.
• W3193969085 cites W2794306047 @default.
• W3193969085 cites W2801243089 @default.
• W3193969085 cites W2804807049 @default.
• W3193969085 cites W2891280030 @default.
• W3193969085 cites W2904826083 @default.
• W3193969085 cites W2925372744 @default.
• W3193969085 cites W2950127240 @default.
• W3193969085 cites W2952474297 @default.
• W3193969085 cites W2959967629 @default.
• W3193969085 cites W2973748748 @default.
• W3193969085 cites W2983682411 @default.
• W3193969085 cites W2995856749 @default.
• W3193969085 cites W3000590594 @default.
• W3193969085 cites W3017104301 @default.
• W3193969085 cites W3027500808 @default.
• W3193969085 cites W3080261933 @default.
• W3193969085 cites W3096057447 @default.
• W3193969085 cites W3117468114 @default.
• W3193969085 cites W3121721954 @default.
• W3193969085 cites W3129277418 @default.
• W3193969085 cites W3158443324 @default.
• W3193969085 cites W3179637429 @default.
• W3193969085 cites W90856989 @default.
• W3193969085 doi "https://doi.org/10.3390/ani11082466" @default.
• W3193969085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8388770" @default.
• W3193969085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34438923" @default.
• W3193969085 hasPublicationYear "2021" @default.
• W3193969085 type Work @default.
• W3193969085 sameAs 3193969085 @default.
• W3193969085 citedByCount "3" @default.
• W3193969085 countsByYear W31939690852022 @default.
• W3193969085 crossrefType "journal-article" @default.
• W3193969085 hasAuthorship W3193969085A5002934621 @default.
• W3193969085 hasAuthorship W3193969085A5008116526 @default.
• W3193969085 hasAuthorship W3193969085A5024461534 @default.
• W3193969085 hasAuthorship W3193969085A5034849565 @default.
• W3193969085 hasAuthorship W3193969085A5061205644 @default.
• W3193969085 hasAuthorship W3193969085A5064643672 @default.
• W3193969085 hasAuthorship W3193969085A5091663866 @default.
• W3193969085 hasBestOaLocation W31939690851 @default.
• W3193969085 hasConcept C104317684 @default.
• W3193969085 hasConcept C126322002 @default.
• W3193969085 hasConcept C134018914 @default.
• W3193969085 hasConcept C142724271 @default.
• W3193969085 hasConcept C145059251 @default.
• W3193969085 hasConcept C171089720 @default.
• W3193969085 hasConcept C198826908 @default.
• W3193969085 hasConcept C203014093 @default.

• next