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- W3193995382 abstract "Ischemic postconditioning (IPostC) protects against brain injury induced by stroke and is a potential strategy for ischemic stroke treatment. Understanding its underlying mechanisms and potential hurdles is essential for clinical translation. In this review article, we will summarize the current advances in IPostC for stroke treatment and the underlying protective mechanisms. Strong evidence suggests that IPostC reduces brain infarct size, attenuates blood-brain barrier (BBB) damage and brain edema, and improves neurological outcomes. IPostC also promotes neurogenesis and angiogenesis at the recovery phase of ischemic stroke. The protective mechanisms involve its effects on anti-oxidative stress, anti-inflammation, and anti-apoptosis. In addition, it regulates neurotransmitter receptors, ion channels, heat shock proteins (HSP) 40/70, as well as growth factors such as BDNF and VEGF. Furthermore, IPostC modulates several cell signaling pathways, including the PI3K/Akt, MAPK, NF-κB, and the Gluk2/PSD95/MLK3/MKK7/JNK3 pathways. We also discuss the potential hurdles for IPostC's clinical translation, including insufficient IPostC algorithm studies, such as therapeutic time windows and ischemia-reperfusion periods and cycles, as well as its long-term protection. In addition, future studies should address confounding factors such as age, sex, and pre-existing conditions such as hypertension and hyperglycemia before stroke onset. At last, the combination of IPostC with other treatments, such as tissue plasminogen activator (t-PA), merits further exploration." @default.
- W3193995382 created "2021-08-30" @default.
- W3193995382 creator A5013509380 @default.
- W3193995382 creator A5055327692 @default.
- W3193995382 creator A5078424164 @default.
- W3193995382 date "2020-04-01" @default.
- W3193995382 modified "2023-10-01" @default.
- W3193995382 title "Ischemic postconditioning for stroke treatment: current experimental advances and future directions." @default.
- W3193995382 cites W106703604 @default.
- W3193995382 cites W1519491057 @default.
- W3193995382 cites W1523932090 @default.
- W3193995382 cites W1691576831 @default.
- W3193995382 cites W18603037 @default.
- W3193995382 cites W1946311189 @default.
- W3193995382 cites W1965467525 @default.
- W3193995382 cites W1978537408 @default.
- W3193995382 cites W1985808298 @default.
- W3193995382 cites W1986723404 @default.
- W3193995382 cites W1988090725 @default.
- W3193995382 cites W1989141035 @default.
- W3193995382 cites W1990330616 @default.
- W3193995382 cites W1991001635 @default.
- W3193995382 cites W1991597061 @default.
- W3193995382 cites W1992835141 @default.
- W3193995382 cites W1996062801 @default.
- W3193995382 cites W2004414376 @default.
- W3193995382 cites W2010866100 @default.
- W3193995382 cites W2011136055 @default.
- W3193995382 cites W2014906425 @default.
- W3193995382 cites W2021321633 @default.
- W3193995382 cites W2025988335 @default.
- W3193995382 cites W2026572187 @default.
- W3193995382 cites W2028861733 @default.
- W3193995382 cites W2031704147 @default.
- W3193995382 cites W2032987213 @default.
- W3193995382 cites W2035477351 @default.
- W3193995382 cites W2036451329 @default.
- W3193995382 cites W2043728611 @default.
- W3193995382 cites W2050867990 @default.
- W3193995382 cites W2053461574 @default.
- W3193995382 cites W2055678857 @default.
- W3193995382 cites W2058602470 @default.
- W3193995382 cites W2060208551 @default.
- W3193995382 cites W2062033337 @default.
- W3193995382 cites W2065812700 @default.
- W3193995382 cites W2071015994 @default.
- W3193995382 cites W2072570965 @default.
- W3193995382 cites W2076203393 @default.
- W3193995382 cites W2080600302 @default.
- W3193995382 cites W2081574942 @default.
- W3193995382 cites W2083004303 @default.
- W3193995382 cites W2087177155 @default.
- W3193995382 cites W2088494886 @default.
- W3193995382 cites W2093697162 @default.
- W3193995382 cites W2094393593 @default.
- W3193995382 cites W2098089927 @default.
- W3193995382 cites W2100463961 @default.
- W3193995382 cites W2101350212 @default.
- W3193995382 cites W2114472543 @default.
- W3193995382 cites W2125280689 @default.
- W3193995382 cites W2127789666 @default.
- W3193995382 cites W2134998372 @default.
- W3193995382 cites W2151653182 @default.
- W3193995382 cites W2155022212 @default.
- W3193995382 cites W2155603664 @default.
- W3193995382 cites W2155793940 @default.
- W3193995382 cites W2159285490 @default.
- W3193995382 cites W2159881264 @default.
- W3193995382 cites W2160867364 @default.
- W3193995382 cites W2161099598 @default.
- W3193995382 cites W2164240382 @default.
- W3193995382 cites W2182395860 @default.
- W3193995382 cites W2312765121 @default.
- W3193995382 cites W2315512256 @default.
- W3193995382 cites W2341341310 @default.
- W3193995382 cites W2409163058 @default.
- W3193995382 cites W2414070939 @default.
- W3193995382 cites W2417819518 @default.
- W3193995382 cites W2444478642 @default.
- W3193995382 cites W2485876088 @default.
- W3193995382 cites W2525949321 @default.
- W3193995382 cites W2574654210 @default.
- W3193995382 cites W2577324650 @default.
- W3193995382 cites W2766538169 @default.
- W3193995382 cites W2766909989 @default.
- W3193995382 cites W2767776410 @default.
- W3193995382 cites W2770807583 @default.
- W3193995382 cites W2787867590 @default.
- W3193995382 cites W2790402886 @default.
- W3193995382 cites W2791453970 @default.
- W3193995382 cites W2794241261 @default.
- W3193995382 cites W2795007063 @default.
- W3193995382 cites W2802167882 @default.
- W3193995382 cites W2807737819 @default.
- W3193995382 cites W2883889659 @default.
- W3193995382 cites W2891678861 @default.
- W3193995382 cites W2895240848 @default.
- W3193995382 cites W2896425167 @default.