Matches in SemOpenAlex for { <https://semopenalex.org/work/W3194026024> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3194026024 endingPage "1240" @default.
- W3194026024 startingPage "1232" @default.
- W3194026024 abstract "Background: The oncologic safety of transanal total mesorectal excision (TaTME) for rectal cancer has recently been questioned, with high local recurrence (LR) rates reported in Dutch and Norwegian experiences. The objective of this study was to evaluate the oncologic safety of TaTME in a large cohort of patients with primary rectal cancer, primarily in terms of LR, disease-free survival (DFS), and overall survival (OS). Patients and Methods: This was a prospective international registry cohort study, including all patients who underwent TaTME for primary rectal adenocarcinoma from February 2010 through December 2018. The main endpoints were 2-year LR rate, pattern of LR, and independent risk factors for LR. Secondary endpoints included 2-year DFS and OS rates. Kaplan-Meier survival analysis was used to calculate actuarial LR, DFS, and OS rates. Results: A total of 2,803 patients receiving primary TaTME were included, predominantly men (71%) with a median age of 65 years (interquartile ratio, 57–73 years). After a median follow-up of 24 months (interquartile ratio, 12–38 months), the 2-year LR rate was 4.8% (95% CI, 3.8%–5.8%) with a unifocal LR pattern in 99 of 103 patients (96%). Independent risk factors for LR were male sex, threatened resection margin on baseline MRI, pathologic stage III cancer, and a positive circumferential resection margin on final histopathology. The 2-year DFS and OS rates were 77% (95% CI, 75%–79%) and 92% (95% CI, 91%–93%), respectively. Conclusions: This largest TaTME cohort to date supports the oncologic safety of the TaTME technique for rectal cancer in patients treated in units that contributed to an international registry, with an acceptable 2-year LR rate and a predominantly unifocal LR pattern." @default.
- W3194026024 created "2021-08-30" @default.
- W3194026024 creator A5024739560 @default.
- W3194026024 creator A5026697149 @default.
- W3194026024 creator A5034987550 @default.
- W3194026024 creator A5059237548 @default.
- W3194026024 creator A5074964050 @default.
- W3194026024 creator A5076036301 @default.
- W3194026024 creator A5086442158 @default.
- W3194026024 date "2021-11-01" @default.
- W3194026024 modified "2023-10-12" @default.
- W3194026024 title "Local Recurrence and Disease-Free Survival After Transanal Total Mesorectal Excision: Results From the International TaTME Registry" @default.
- W3194026024 cites W1926888387 @default.
- W3194026024 cites W1969561516 @default.
- W3194026024 cites W2000687665 @default.
- W3194026024 cites W2007244790 @default.
- W3194026024 cites W2015712245 @default.
- W3194026024 cites W2019275335 @default.
- W3194026024 cites W2036477956 @default.
- W3194026024 cites W2095597468 @default.
- W3194026024 cites W2104029004 @default.
- W3194026024 cites W2106014206 @default.
- W3194026024 cites W2146460633 @default.
- W3194026024 cites W2146706361 @default.
- W3194026024 cites W2160042758 @default.
- W3194026024 cites W2467608820 @default.
- W3194026024 cites W2538786758 @default.
- W3194026024 cites W2551940048 @default.
- W3194026024 cites W2606262820 @default.
- W3194026024 cites W2781601582 @default.
- W3194026024 cites W2894414422 @default.
- W3194026024 cites W2915625677 @default.
- W3194026024 cites W2917062475 @default.
- W3194026024 cites W2959001132 @default.
- W3194026024 cites W2975717824 @default.
- W3194026024 cites W2980263850 @default.
- W3194026024 cites W2986987959 @default.
- W3194026024 cites W2993557527 @default.
- W3194026024 cites W3006894244 @default.
- W3194026024 cites W3015026441 @default.
- W3194026024 doi "https://doi.org/10.6004/jnccn.2021.7012" @default.
- W3194026024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34404028" @default.
- W3194026024 hasPublicationYear "2021" @default.
- W3194026024 type Work @default.
- W3194026024 sameAs 3194026024 @default.
- W3194026024 citedByCount "16" @default.
- W3194026024 countsByYear W31940260242021 @default.
- W3194026024 countsByYear W31940260242022 @default.
- W3194026024 countsByYear W31940260242023 @default.
- W3194026024 crossrefType "journal-article" @default.
- W3194026024 hasAuthorship W3194026024A5024739560 @default.
- W3194026024 hasAuthorship W3194026024A5026697149 @default.
- W3194026024 hasAuthorship W3194026024A5034987550 @default.
- W3194026024 hasAuthorship W3194026024A5059237548 @default.
- W3194026024 hasAuthorship W3194026024A5074964050 @default.
- W3194026024 hasAuthorship W3194026024A5076036301 @default.
- W3194026024 hasAuthorship W3194026024A5086442158 @default.
- W3194026024 hasBestOaLocation W31940260241 @default.
- W3194026024 hasConcept C119060515 @default.
- W3194026024 hasConcept C121608353 @default.
- W3194026024 hasConcept C126322002 @default.
- W3194026024 hasConcept C141071460 @default.
- W3194026024 hasConcept C188816634 @default.
- W3194026024 hasConcept C2777201421 @default.
- W3194026024 hasConcept C2778527826 @default.
- W3194026024 hasConcept C526805850 @default.
- W3194026024 hasConcept C71924100 @default.
- W3194026024 hasConcept C72563966 @default.
- W3194026024 hasConceptScore W3194026024C119060515 @default.
- W3194026024 hasConceptScore W3194026024C121608353 @default.
- W3194026024 hasConceptScore W3194026024C126322002 @default.
- W3194026024 hasConceptScore W3194026024C141071460 @default.
- W3194026024 hasConceptScore W3194026024C188816634 @default.
- W3194026024 hasConceptScore W3194026024C2777201421 @default.
- W3194026024 hasConceptScore W3194026024C2778527826 @default.
- W3194026024 hasConceptScore W3194026024C526805850 @default.
- W3194026024 hasConceptScore W3194026024C71924100 @default.
- W3194026024 hasConceptScore W3194026024C72563966 @default.
- W3194026024 hasIssue "11" @default.
- W3194026024 hasLocation W31940260241 @default.
- W3194026024 hasLocation W31940260242 @default.
- W3194026024 hasOpenAccess W3194026024 @default.
- W3194026024 hasPrimaryLocation W31940260241 @default.
- W3194026024 hasRelatedWork W2049515180 @default.
- W3194026024 hasRelatedWork W2126365059 @default.
- W3194026024 hasRelatedWork W2487490720 @default.
- W3194026024 hasRelatedWork W2606644627 @default.
- W3194026024 hasRelatedWork W2793077515 @default.
- W3194026024 hasRelatedWork W2980097659 @default.
- W3194026024 hasRelatedWork W2981615369 @default.
- W3194026024 hasRelatedWork W3048651736 @default.
- W3194026024 hasRelatedWork W4292573045 @default.
- W3194026024 hasRelatedWork W4386009577 @default.
- W3194026024 hasVolume "19" @default.
- W3194026024 isParatext "false" @default.
- W3194026024 isRetracted "false" @default.
- W3194026024 magId "3194026024" @default.
- W3194026024 workType "article" @default.