FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3194078603> ?p ?o ?g. }

• W3194078603 endingPage "1257" @default.
• W3194078603 startingPage "1257" @default.
• W3194078603 abstract "Amorphous solid dispersion (ASD) dosage forms can improve the oral bioavailability of poorly water-soluble drugs, enabling the commercialization of new chemical entities and improving the efficacy and patient compliance of existing drugs. However, the development of robust, high-performing ASD dosage forms can be challenging, often requiring multiple formulation iterations, long timelines, and high cost. In a previous study, acalabrutinib/hydroxypropyl methylcellulose acetate succinate (HPMCAS)-H grade ASD tablets were shown to overcome the pH effect of commercially marketed Calquence in beagle dogs. This study describes the streamlined in vitro and in silico approach used to develop those ASD tablets. HPMCAS-H and -M grade polymers provided the longest acalabrutinib supersaturation sustainment in an initial screening study, and HPMCAS-H grade ASDs provided the highest in vitro area under the curve (AUC) in gastric to intestinal transfer dissolution tests at elevated gastric pH. In silico simulations of the HPMCAS-H ASD tablet and Calquence capsule provided good in vivo study prediction accuracy using a bottom-up approach (absolute average fold error of AUC0-inf < 2). This streamlined approach combined an understanding of key drug, polymer, and gastrointestinal properties with in vitro and in silico tools to overcome the acalabrutinib pH effect without the need for reformulation or multiple studies, showing promise for reducing time and costs to develop ASD drug products." @default.
• W3194078603 created "2021-08-30" @default.
• W3194078603 creator A5004503177 @default.
• W3194078603 creator A5045108451 @default.
• W3194078603 creator A5046423974 @default.
• W3194078603 creator A5053314890 @default.
• W3194078603 creator A5074171886 @default.
• W3194078603 creator A5089244832 @default.
• W3194078603 date "2021-08-13" @default.
• W3194078603 modified "2023-10-18" @default.
• W3194078603 title "In Vitro-In Silico Tools for Streamlined Development of Acalabrutinib Amorphous Solid Dispersion Tablets" @default.
• W3194078603 cites W1579212850 @default.
• W3194078603 cites W1980250492 @default.
• W3194078603 cites W2002795751 @default.
• W3194078603 cites W2040451910 @default.
• W3194078603 cites W2041517295 @default.
• W3194078603 cites W2048702787 @default.
• W3194078603 cites W2060318369 @default.
• W3194078603 cites W2065956337 @default.
• W3194078603 cites W2080081537 @default.
• W3194078603 cites W2100116917 @default.
• W3194078603 cites W2115158577 @default.
• W3194078603 cites W2130760903 @default.
• W3194078603 cites W2151520572 @default.
• W3194078603 cites W2298359086 @default.
• W3194078603 cites W2315526175 @default.
• W3194078603 cites W2477997774 @default.
• W3194078603 cites W2521542655 @default.
• W3194078603 cites W2523598733 @default.
• W3194078603 cites W2622240386 @default.
• W3194078603 cites W2895560947 @default.
• W3194078603 cites W2901139388 @default.
• W3194078603 cites W2901419844 @default.
• W3194078603 cites W2913459797 @default.
• W3194078603 cites W2939818942 @default.
• W3194078603 cites W2957727312 @default.
• W3194078603 cites W2962176750 @default.
• W3194078603 cites W2987630388 @default.
• W3194078603 cites W2989643690 @default.
• W3194078603 cites W2991263237 @default.
• W3194078603 cites W2996382799 @default.
• W3194078603 cites W2998483413 @default.
• W3194078603 cites W3003356479 @default.
• W3194078603 cites W3081275730 @default.
• W3194078603 cites W3119587410 @default.
• W3194078603 cites W3127627036 @default.
• W3194078603 cites W3130309548 @default.
• W3194078603 cites W3130899234 @default.
• W3194078603 cites W3156757032 @default.
• W3194078603 doi "https://doi.org/10.3390/pharmaceutics13081257" @default.
• W3194078603 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8398755" @default.
• W3194078603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34452217" @default.
• W3194078603 hasPublicationYear "2021" @default.
• W3194078603 type Work @default.
• W3194078603 sameAs 3194078603 @default.
• W3194078603 citedByCount "4" @default.
• W3194078603 countsByYear W31940786032021 @default.
• W3194078603 countsByYear W31940786032022 @default.
• W3194078603 countsByYear W31940786032023 @default.
• W3194078603 crossrefType "journal-article" @default.
• W3194078603 hasAuthorship W3194078603A5004503177 @default.
• W3194078603 hasAuthorship W3194078603A5045108451 @default.
• W3194078603 hasAuthorship W3194078603A5046423974 @default.
• W3194078603 hasAuthorship W3194078603A5053314890 @default.
• W3194078603 hasAuthorship W3194078603A5074171886 @default.
• W3194078603 hasAuthorship W3194078603A5089244832 @default.
• W3194078603 hasBestOaLocation W31940786031 @default.
• W3194078603 hasConcept C104317684 @default.
• W3194078603 hasConcept C136229726 @default.
• W3194078603 hasConcept C14029885 @default.
• W3194078603 hasConcept C181389837 @default.
• W3194078603 hasConcept C185592680 @default.
• W3194078603 hasConcept C192562407 @default.
• W3194078603 hasConcept C2775905019 @default.
• W3194078603 hasConcept C2779484521 @default.
• W3194078603 hasConcept C2781430271 @default.
• W3194078603 hasConcept C43617362 @default.
• W3194078603 hasConcept C55493867 @default.
• W3194078603 hasConcept C71924100 @default.
• W3194078603 hasConcept C77281830 @default.
• W3194078603 hasConcept C98274493 @default.
• W3194078603 hasConceptScore W3194078603C104317684 @default.
• W3194078603 hasConceptScore W3194078603C136229726 @default.
• W3194078603 hasConceptScore W3194078603C14029885 @default.
• W3194078603 hasConceptScore W3194078603C181389837 @default.
• W3194078603 hasConceptScore W3194078603C185592680 @default.
• W3194078603 hasConceptScore W3194078603C192562407 @default.
• W3194078603 hasConceptScore W3194078603C2775905019 @default.
• W3194078603 hasConceptScore W3194078603C2779484521 @default.
• W3194078603 hasConceptScore W3194078603C2781430271 @default.
• W3194078603 hasConceptScore W3194078603C43617362 @default.
• W3194078603 hasConceptScore W3194078603C55493867 @default.
• W3194078603 hasConceptScore W3194078603C71924100 @default.
• W3194078603 hasConceptScore W3194078603C77281830 @default.
• W3194078603 hasConceptScore W3194078603C98274493 @default.
• W3194078603 hasIssue "8" @default.
• W3194078603 hasLocation W31940786031 @default.
• W3194078603 hasLocation W31940786032 @default.

• next