FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3194082837> ?p ?o ?g. }

• W3194082837 abstract "Osteoarthritis (OA) is the most common joint degenerative disorder, with little effective therapy to date. Nanofat is a cocktail of cells obtained from fat tissue, which possesses regenerative capacity and has a potential in treating OA. This study aimed to determine the anti-OA efficacy of Nanofat from basic and clinical aspects and explore its action mode.Flow cytometry was performed to characterize Nanofat. A monoiodoacetate-induced OA rat model was employed for in vivo study. Cell viability and wound healing assays were conducted for in vitro study. Real-time PCR and Western blot assays were applied to explore the molecular action mode of Nanofat. Moreover, a retrospective analysis was conducted to determine the clinical efficacy and safety of Nanofat on knee OA patients.The in vivo results showed that Nanofat significantly attenuated pain symptoms and protected cartilage ECM (Col2) from damage, and its effects were not significantly differed with adipose tissue-derived stem cells (both P > 0.05). The in vitro results showed that Nanofat promoted the cell viability and migration of chondrocytes and significantly restored the IL-1β-induced abnormal gene expressions of Col2, Aggrecan, Sox9, Adamts5, Mmp3, Mmp9 Mmp13, IL-6 and Col10 and protein expressions of Col2, MMP9, MMP13, and Sox9 of chondrocytes. The regulatory actions of Nanofat on these anabolic, catabolic, and hypertrophic molecules of chondrocytes were similar between two treatment routes: co-culture and conditioned medium, suggesting a paracrine-based mode of action of Nanofat. Moreover, the clinical data showed that Nanofat relieved pain and repaired damaged cartilage of OA patients, with no adverse events.In sum, this study demonstrated the anti-OA efficacy as well as a paracrine-based action mode of Nanofat, providing novel knowledge of Nanofat and suggesting it as a promising and practical cell therapy for clinical treatment of OA." @default.
• W3194082837 created "2021-08-30" @default.
• W3194082837 creator A5000236007 @default.
• W3194082837 creator A5009084686 @default.
• W3194082837 creator A5019047946 @default.
• W3194082837 creator A5029892501 @default.
• W3194082837 creator A5031051951 @default.
• W3194082837 creator A5035831137 @default.
• W3194082837 creator A5048640231 @default.
• W3194082837 creator A5050038706 @default.
• W3194082837 creator A5057477569 @default.
• W3194082837 creator A5068688179 @default.
• W3194082837 date "2021-08-26" @default.
• W3194082837 modified "2023-10-16" @default.
• W3194082837 title "Pain relief and cartilage repair by Nanofat against osteoarthritis: preclinical and clinical evidence" @default.
• W3194082837 cites W1512798675 @default.
• W3194082837 cites W1638726677 @default.
• W3194082837 cites W1967029176 @default.
• W3194082837 cites W1967362684 @default.
• W3194082837 cites W1983106010 @default.
• W3194082837 cites W1983766143 @default.
• W3194082837 cites W2027039405 @default.
• W3194082837 cites W2054001111 @default.
• W3194082837 cites W2077814461 @default.
• W3194082837 cites W2081605022 @default.
• W3194082837 cites W2083156208 @default.
• W3194082837 cites W2087234810 @default.
• W3194082837 cites W2088413704 @default.
• W3194082837 cites W2091076719 @default.
• W3194082837 cites W2095671077 @default.
• W3194082837 cites W2102525474 @default.
• W3194082837 cites W2109934828 @default.
• W3194082837 cites W2115805053 @default.
• W3194082837 cites W2140513563 @default.
• W3194082837 cites W2155900557 @default.
• W3194082837 cites W2161736885 @default.
• W3194082837 cites W2173497140 @default.
• W3194082837 cites W2298897662 @default.
• W3194082837 cites W2507195900 @default.
• W3194082837 cites W2581109444 @default.
• W3194082837 cites W2591784319 @default.
• W3194082837 cites W2592442606 @default.
• W3194082837 cites W2601930077 @default.
• W3194082837 cites W2610860323 @default.
• W3194082837 cites W2613652562 @default.
• W3194082837 cites W2625285338 @default.
• W3194082837 cites W2661440646 @default.
• W3194082837 cites W2728494373 @default.
• W3194082837 cites W2739388690 @default.
• W3194082837 cites W2884972418 @default.
• W3194082837 cites W2894885260 @default.
• W3194082837 cites W2896243120 @default.
• W3194082837 cites W2896730767 @default.
• W3194082837 cites W2896752456 @default.
• W3194082837 cites W2946158969 @default.
• W3194082837 cites W2950151274 @default.
• W3194082837 cites W2954239344 @default.
• W3194082837 cites W2969798557 @default.
• W3194082837 cites W2996774074 @default.
• W3194082837 cites W3013522609 @default.
• W3194082837 cites W3092275309 @default.
• W3194082837 cites W3092842340 @default.
• W3194082837 doi "https://doi.org/10.1186/s13287-021-02538-9" @default.
• W3194082837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8390235" @default.
• W3194082837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34446107" @default.
• W3194082837 hasPublicationYear "2021" @default.
• W3194082837 type Work @default.
• W3194082837 sameAs 3194082837 @default.
• W3194082837 citedByCount "9" @default.
• W3194082837 countsByYear W31940828372022 @default.
• W3194082837 countsByYear W31940828372023 @default.
• W3194082837 crossrefType "journal-article" @default.
• W3194082837 hasAuthorship W3194082837A5000236007 @default.
• W3194082837 hasAuthorship W3194082837A5009084686 @default.
• W3194082837 hasAuthorship W3194082837A5019047946 @default.
• W3194082837 hasAuthorship W3194082837A5029892501 @default.
• W3194082837 hasAuthorship W3194082837A5031051951 @default.
• W3194082837 hasAuthorship W3194082837A5035831137 @default.
• W3194082837 hasAuthorship W3194082837A5048640231 @default.
• W3194082837 hasAuthorship W3194082837A5050038706 @default.
• W3194082837 hasAuthorship W3194082837A5057477569 @default.
• W3194082837 hasAuthorship W3194082837A5068688179 @default.
• W3194082837 hasBestOaLocation W31940828371 @default.
• W3194082837 hasConcept C105702510 @default.
• W3194082837 hasConcept C126322002 @default.
• W3194082837 hasConcept C142724271 @default.
• W3194082837 hasConcept C150903083 @default.
• W3194082837 hasConcept C170493617 @default.
• W3194082837 hasConcept C185592680 @default.
• W3194082837 hasConcept C197534660 @default.
• W3194082837 hasConcept C204787440 @default.
• W3194082837 hasConcept C207001950 @default.
• W3194082837 hasConcept C2776164576 @default.
• W3194082837 hasConcept C2780550940 @default.
• W3194082837 hasConcept C28328180 @default.
• W3194082837 hasConcept C3020332539 @default.
• W3194082837 hasConcept C71924100 @default.
• W3194082837 hasConcept C7876069 @default.
• W3194082837 hasConcept C86803240 @default.
• W3194082837 hasConcept C95444343 @default.

• next