FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3194133082> ?p ?o ?g. }

• W3194133082 endingPage "8850" @default.
• W3194133082 startingPage "8850" @default.
• W3194133082 abstract "Since their discovery, R-loops have been associated with both physiological and pathological functions that are conserved across species. R-loops are a source of replication stress and genome instability, as seen in neurodegenerative disorders and cancer. In response, cells have evolved pathways to prevent R-loop accumulation as well as to resolve them. A growing body of evidence correlates R-loop accumulation with changes in the epigenetic landscape. However, the role of chromatin modification and remodeling in R-loops homeostasis remains unclear. This review covers various mechanisms precluding R-loop accumulation and highlights the role of chromatin modifiers and remodelers in facilitating timely R-loop resolution. We also discuss the enigmatic role of RNA:DNA hybrids in facilitating DNA repair, epigenetic landscape and the potential role of replication fork preservation pathways, active fork stability and stalled fork protection pathways, in avoiding replication-transcription conflicts. Finally, we discuss the potential role of several Chro-Mates (chromatin modifiers and remodelers) in the likely differentiation between persistent/detrimental R-loops and transient/benign R-loops that assist in various physiological processes relevant for therapeutic interventions." @default.
• W3194133082 created "2021-08-30" @default.
• W3194133082 creator A5006526845 @default.
• W3194133082 creator A5017261702 @default.
• W3194133082 creator A5054147889 @default.
• W3194133082 creator A5061025641 @default.
• W3194133082 date "2021-08-17" @default.
• W3194133082 modified "2023-10-12" @default.
• W3194133082 title "R-Loops and Its Chro-Mates: The Strange Case of Dr. Jekyll and Mr. Hyde" @default.
• W3194133082 cites W1479904481 @default.
• W3194133082 cites W1487538033 @default.
• W3194133082 cites W1557728494 @default.
• W3194133082 cites W1615790672 @default.
• W3194133082 cites W1838266191 @default.
• W3194133082 cites W1913397935 @default.
• W3194133082 cites W1964640891 @default.
• W3194133082 cites W1964680558 @default.
• W3194133082 cites W1964787686 @default.
• W3194133082 cites W1966987389 @default.
• W3194133082 cites W1967012607 @default.
• W3194133082 cites W1967154926 @default.
• W3194133082 cites W1967706132 @default.
• W3194133082 cites W1968789240 @default.
• W3194133082 cites W1970578083 @default.
• W3194133082 cites W1970966311 @default.
• W3194133082 cites W1971503458 @default.
• W3194133082 cites W1972011626 @default.
• W3194133082 cites W1973101872 @default.
• W3194133082 cites W1973425717 @default.
• W3194133082 cites W1973857401 @default.
• W3194133082 cites W1975993845 @default.
• W3194133082 cites W1977642285 @default.
• W3194133082 cites W1977826612 @default.
• W3194133082 cites W1978518304 @default.
• W3194133082 cites W1983289953 @default.
• W3194133082 cites W1989187665 @default.
• W3194133082 cites W1989540449 @default.
• W3194133082 cites W1990347983 @default.
• W3194133082 cites W1992002234 @default.
• W3194133082 cites W1993779286 @default.
• W3194133082 cites W1993973779 @default.
• W3194133082 cites W1994060558 @default.
• W3194133082 cites W1995842607 @default.
• W3194133082 cites W1999626396 @default.
• W3194133082 cites W2001372713 @default.
• W3194133082 cites W2002394441 @default.
• W3194133082 cites W2003719212 @default.
• W3194133082 cites W2004178776 @default.
• W3194133082 cites W2007446614 @default.
• W3194133082 cites W2010521897 @default.
• W3194133082 cites W2010759469 @default.
• W3194133082 cites W2013235095 @default.
• W3194133082 cites W2013351263 @default.
• W3194133082 cites W2018366980 @default.
• W3194133082 cites W2019248098 @default.
• W3194133082 cites W2031816743 @default.
• W3194133082 cites W2039757117 @default.
• W3194133082 cites W2039885485 @default.
• W3194133082 cites W2040860750 @default.
• W3194133082 cites W2041959419 @default.
• W3194133082 cites W2043375872 @default.
• W3194133082 cites W2043745733 @default.
• W3194133082 cites W2044375974 @default.
• W3194133082 cites W2046764234 @default.
• W3194133082 cites W2051848082 @default.
• W3194133082 cites W2053874183 @default.
• W3194133082 cites W2054197881 @default.
• W3194133082 cites W2057990302 @default.
• W3194133082 cites W2059453176 @default.
• W3194133082 cites W2060955969 @default.
• W3194133082 cites W2064558750 @default.
• W3194133082 cites W2065395316 @default.
• W3194133082 cites W2065779053 @default.
• W3194133082 cites W2065884484 @default.
• W3194133082 cites W2066322721 @default.
• W3194133082 cites W2069202014 @default.
• W3194133082 cites W2069237225 @default.
• W3194133082 cites W2070125324 @default.
• W3194133082 cites W2077272518 @default.
• W3194133082 cites W2078403259 @default.
• W3194133082 cites W2079035635 @default.
• W3194133082 cites W2079044543 @default.
• W3194133082 cites W2080278886 @default.
• W3194133082 cites W2080840166 @default.
• W3194133082 cites W2080961638 @default.
• W3194133082 cites W2081814828 @default.
• W3194133082 cites W2082810375 @default.
• W3194133082 cites W2084377803 @default.
• W3194133082 cites W2084622414 @default.
• W3194133082 cites W2084674416 @default.
• W3194133082 cites W2084728529 @default.
• W3194133082 cites W2085617522 @default.
• W3194133082 cites W2085631727 @default.
• W3194133082 cites W2089885698 @default.
• W3194133082 cites W2095626300 @default.
• W3194133082 cites W2096380982 @default.
• W3194133082 cites W2099009604 @default.
• W3194133082 cites W2100440853 @default.

• next