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- W3194145765 endingPage "1296" @default.
- W3194145765 startingPage "1296" @default.
- W3194145765 abstract "Epigenetic factors are heritable and ultimately play a role in modulating gene expression and, thus, in regulating cell functions. Non-coding RNAs have growing recognition as novel biomarkers and crucial regulators of pathological conditions in humans. Their characteristic feature is being transcribed in a tissue-specific pattern. Now, there is emerging evidence that lncRNAs have been identified to be involved in the differentiation of human skin, wound healing, fibrosis, inflammation, and immunological response. Systemic sclerosis (SSc) is a heterogeneous autoimmune disease characterized by fibrosis, vascular abnormalities, and immune system activation. The pathogenesis remains elusive, but clinical manifestations reveal autoimmunity with the presence of specific autoantibodies, activation of innate and adaptive immunity, vascular changes, and active deposition of extracellular matrix components leading to fibrosis. The use of multi-omics studies, including NGS, RNA-seq, or GWAS, has proposed that the non-coding genome may be a significant player in its pathogenesis. Moreover, it may unravel new therapeutic targets in the future. The aim of this review is to show the pathogenic role of long non-coding RNAs in systemic sclerosis. Investigation of these transcripts' functions has the potential to elucidate the molecular pathology of SSc and provide new opportunities for drug-targeted therapy for this disorder." @default.
- W3194145765 created "2021-08-30" @default.
- W3194145765 creator A5056739575 @default.
- W3194145765 creator A5059160294 @default.
- W3194145765 date "2021-08-24" @default.
- W3194145765 modified "2023-10-17" @default.
- W3194145765 title "Non-Coding RNA in Systemic Sclerosis: A Valuable Tool for Translational and Personalized Medicine" @default.
- W3194145765 cites W144423133 @default.
- W3194145765 cites W148320297 @default.
- W3194145765 cites W1511422104 @default.
- W3194145765 cites W1540350711 @default.
- W3194145765 cites W1555659633 @default.
- W3194145765 cites W1858503442 @default.
- W3194145765 cites W1866588049 @default.
- W3194145765 cites W1908920007 @default.
- W3194145765 cites W1922984862 @default.
- W3194145765 cites W1966411071 @default.
- W3194145765 cites W1966579788 @default.
- W3194145765 cites W1967480655 @default.
- W3194145765 cites W1985651745 @default.
- W3194145765 cites W1986223165 @default.
- W3194145765 cites W1991129132 @default.
- W3194145765 cites W1995777485 @default.
- W3194145765 cites W1997039404 @default.
- W3194145765 cites W1998727509 @default.
- W3194145765 cites W2005286138 @default.
- W3194145765 cites W2019141144 @default.
- W3194145765 cites W2024866056 @default.
- W3194145765 cites W2029919331 @default.
- W3194145765 cites W2034305079 @default.
- W3194145765 cites W2037585665 @default.
- W3194145765 cites W2038862787 @default.
- W3194145765 cites W2039447393 @default.
- W3194145765 cites W2048724765 @default.
- W3194145765 cites W2049804931 @default.
- W3194145765 cites W2064165694 @default.
- W3194145765 cites W2068205741 @default.
- W3194145765 cites W2068745107 @default.
- W3194145765 cites W2071271349 @default.
- W3194145765 cites W2073396586 @default.
- W3194145765 cites W2078484764 @default.
- W3194145765 cites W2083513379 @default.
- W3194145765 cites W2085095489 @default.
- W3194145765 cites W2085364628 @default.
- W3194145765 cites W2086254436 @default.
- W3194145765 cites W2089969972 @default.
- W3194145765 cites W2090116519 @default.
- W3194145765 cites W2090123245 @default.
- W3194145765 cites W2091161969 @default.
- W3194145765 cites W2093404711 @default.
- W3194145765 cites W2105349784 @default.
- W3194145765 cites W2110892399 @default.
- W3194145765 cites W2113764090 @default.
- W3194145765 cites W2115443085 @default.
- W3194145765 cites W2115486243 @default.
- W3194145765 cites W2115637648 @default.
- W3194145765 cites W2117688129 @default.
- W3194145765 cites W2119869009 @default.
- W3194145765 cites W2130820483 @default.
- W3194145765 cites W2132334809 @default.
- W3194145765 cites W2133644362 @default.
- W3194145765 cites W2138208673 @default.
- W3194145765 cites W2141831115 @default.
- W3194145765 cites W2142718675 @default.
- W3194145765 cites W2146573461 @default.
- W3194145765 cites W2147500784 @default.
- W3194145765 cites W2153146283 @default.
- W3194145765 cites W2153772231 @default.
- W3194145765 cites W2158007484 @default.
- W3194145765 cites W2160333540 @default.
- W3194145765 cites W2161483818 @default.
- W3194145765 cites W2162674813 @default.
- W3194145765 cites W2164113977 @default.
- W3194145765 cites W2165160668 @default.
- W3194145765 cites W2165697084 @default.
- W3194145765 cites W2171143303 @default.
- W3194145765 cites W2172312226 @default.
- W3194145765 cites W2174181728 @default.
- W3194145765 cites W2179493768 @default.
- W3194145765 cites W2181024414 @default.
- W3194145765 cites W2198153867 @default.
- W3194145765 cites W2233495549 @default.
- W3194145765 cites W2237672314 @default.
- W3194145765 cites W2255215236 @default.
- W3194145765 cites W2257408058 @default.
- W3194145765 cites W2267383845 @default.
- W3194145765 cites W2279994616 @default.
- W3194145765 cites W2281211491 @default.
- W3194145765 cites W2295032943 @default.
- W3194145765 cites W2297157127 @default.
- W3194145765 cites W2299513640 @default.
- W3194145765 cites W2313851754 @default.
- W3194145765 cites W2322705883 @default.
- W3194145765 cites W2331822890 @default.
- W3194145765 cites W2341291028 @default.
- W3194145765 cites W2398593123 @default.
- W3194145765 cites W2405024754 @default.
- W3194145765 cites W2412468460 @default.