Matches in SemOpenAlex for { <https://semopenalex.org/work/W3194168707> ?p ?o ?g. }
- W3194168707 endingPage "16" @default.
- W3194168707 startingPage "1" @default.
- W3194168707 abstract "For years, organophosphorus poisoning has been a major concern of health problems throughout the world. An estimated 200,000 acute pesticide poisoning deaths occur each year, many in developing countries. Apart from the agricultural pesticide poisoning, terrorists have used these organophosphorus compounds to attack civilian populations in some countries. Recent misuses of sarin in the Syrian conflict had been reported in 2018. Since the 1950s, the therapy to overcome this health problem is to utilize a reactivator to reactivate the inhibited acetylcholinesterase by these organophosphorus compounds. However, many questions remain unanswered regarding the efficacy and toxicity of this reactivator. Pralidoxime, MMB-4, TMB-4, obidoxime, and HI-6 are the examples of the established oximes, yet they are of insufficient effectiveness in some poisonings and only a limited spectrum of the different nerve agents and pesticides are being covered. Alternatively, an option in the treatment of organophosphorus poisoning that has been explored is through the use of enzyme therapy. Organophosphorus hydrolases are a group of enzymes that look promising for detoxifying organophosphorus compounds and have recently gained much interest. These enzymes have demonstrated remarkable protective and antidotal value against some different organophosphorus compounds in vivo in animal models. Apart from that, enzyme treatments have also been applied for decontamination purposes. In this review, the restrictions and obstacles in the therapeutic development of oximes, along with the new strategies to overcome the problems, are discussed. The emerging interest in enzyme treatment with its advantages and disadvantages is described as well." @default.
- W3194168707 created "2021-08-30" @default.
- W3194168707 creator A5020066772 @default.
- W3194168707 creator A5035786228 @default.
- W3194168707 creator A5036352804 @default.
- W3194168707 creator A5057077115 @default.
- W3194168707 creator A5067087175 @default.
- W3194168707 creator A5068653445 @default.
- W3194168707 creator A5072584402 @default.
- W3194168707 creator A5075076564 @default.
- W3194168707 date "2021-08-20" @default.
- W3194168707 modified "2023-09-27" @default.
- W3194168707 title "Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes" @default.
- W3194168707 cites W109259343 @default.
- W3194168707 cites W11449118 @default.
- W3194168707 cites W1193150064 @default.
- W3194168707 cites W1516154703 @default.
- W3194168707 cites W153430829 @default.
- W3194168707 cites W1565709800 @default.
- W3194168707 cites W1964458064 @default.
- W3194168707 cites W1965030025 @default.
- W3194168707 cites W1965138329 @default.
- W3194168707 cites W1968073114 @default.
- W3194168707 cites W1970192285 @default.
- W3194168707 cites W1976224170 @default.
- W3194168707 cites W1978005789 @default.
- W3194168707 cites W1979237945 @default.
- W3194168707 cites W1983814020 @default.
- W3194168707 cites W1986588490 @default.
- W3194168707 cites W1988692904 @default.
- W3194168707 cites W1997081079 @default.
- W3194168707 cites W2001196915 @default.
- W3194168707 cites W2002156256 @default.
- W3194168707 cites W2003613130 @default.
- W3194168707 cites W2006922857 @default.
- W3194168707 cites W2011868438 @default.
- W3194168707 cites W2013392629 @default.
- W3194168707 cites W2013441107 @default.
- W3194168707 cites W2014109976 @default.
- W3194168707 cites W2015630759 @default.
- W3194168707 cites W2017929879 @default.
- W3194168707 cites W2020527777 @default.
- W3194168707 cites W2022587369 @default.
- W3194168707 cites W2022701147 @default.
- W3194168707 cites W2026024519 @default.
- W3194168707 cites W2026212828 @default.
- W3194168707 cites W2029669944 @default.
- W3194168707 cites W2033294776 @default.
- W3194168707 cites W2034346077 @default.
- W3194168707 cites W2037819309 @default.
- W3194168707 cites W2038197916 @default.
- W3194168707 cites W2040103562 @default.
- W3194168707 cites W2041445362 @default.
- W3194168707 cites W2044754143 @default.
- W3194168707 cites W2055986456 @default.
- W3194168707 cites W2056666326 @default.
- W3194168707 cites W2060883036 @default.
- W3194168707 cites W2061150572 @default.
- W3194168707 cites W2061284456 @default.
- W3194168707 cites W2063246933 @default.
- W3194168707 cites W2063385685 @default.
- W3194168707 cites W2070556630 @default.
- W3194168707 cites W2072494371 @default.
- W3194168707 cites W2077060608 @default.
- W3194168707 cites W2078136648 @default.
- W3194168707 cites W2082340369 @default.
- W3194168707 cites W2083461705 @default.
- W3194168707 cites W2087538505 @default.
- W3194168707 cites W2088796427 @default.
- W3194168707 cites W2090908479 @default.
- W3194168707 cites W2095848667 @default.
- W3194168707 cites W2095857210 @default.
- W3194168707 cites W2096125905 @default.
- W3194168707 cites W2107952228 @default.
- W3194168707 cites W2115475052 @default.
- W3194168707 cites W2124367513 @default.
- W3194168707 cites W2142852307 @default.
- W3194168707 cites W2143984301 @default.
- W3194168707 cites W2149196013 @default.
- W3194168707 cites W2167965755 @default.
- W3194168707 cites W2278057954 @default.
- W3194168707 cites W2280093419 @default.
- W3194168707 cites W2315996261 @default.
- W3194168707 cites W2318392461 @default.
- W3194168707 cites W2330536723 @default.
- W3194168707 cites W2338781815 @default.
- W3194168707 cites W2343866984 @default.
- W3194168707 cites W2395783725 @default.
- W3194168707 cites W2402857634 @default.
- W3194168707 cites W2407471277 @default.
- W3194168707 cites W2409146953 @default.
- W3194168707 cites W2463449842 @default.
- W3194168707 cites W2473053464 @default.
- W3194168707 cites W2476302008 @default.
- W3194168707 cites W2559571981 @default.
- W3194168707 cites W2591976773 @default.
- W3194168707 cites W2612183699 @default.
- W3194168707 cites W2619496385 @default.