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• W3194250489 abstract "The use of regorafenib in the treatment of patients with metastatic colorectal cancer divides Russian and foreign oncologists into two camps. Many specialists postpone its appointment until a situation where all other options for systemic therapy have been exhausted, and the physical condition is close to unsatisfactory, and the metastatic process reaches its maximum volume. The position of oncologists adhering to such positions is based on a small number of objective answers and low survival rates without signs of progression of the process, with evidence of a more effective re-prescription of chemotherapy and targeted drugs already used in the treatment of this patient. On the other hand, an analysis of the world literature on regorafenib and options for the third line of therapy for metastatic colorectal cancer shows the ambiguity of the above approach and the potential of the drug in terms of improving the patient’s prospects by overcoming the resistance of the tumor mass to already used drugs and the ability to provide the patient with the so-called chemotherapeutic holiday." @default.
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• W3194250489 date "2021-08-18" @default.
• W3194250489 modified "2023-09-27" @default.
• W3194250489 title "Place of regorafenib in treatment of patients with metastatic colorectal cancer: when are all options exhausted? Or in third line?" @default.
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• W3194250489 doi "https://doi.org/10.33667/2078-5631-2021-19-30-35" @default.
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