FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3194290807> ?p ?o ?g. }

• W3194290807 endingPage "e00950" @default.
• W3194290807 startingPage "e00950" @default.
• W3194290807 abstract "Allanblackia floribunda Oliv. (Elephant rice) belongs to the family Clusiaceae. It is confined to tropical Africa where it is used traditionally for the treatment of malaria, asthma and inflammatory diseases. This study evaluated the biological activity of methanol extract of A. floribunda's stem bark and leaf in addition to the seed oil as well as the subchronic toxicity of the stem bark extract. Standards procedures were used to screen the biological activity of A. floribunda . The subchronic toxicity profile was investigated by administering orally 100, 300 and 600 mg/kg b. wt of the stem bark extract to male Albino rats for 28 days consecutively. After the treatment period, changes in the various biochemical parameters and alteration in the expression of antioxidants, cytokine, Kidney injury molecule-1 (KIM-1) and albumin genes of the sensitive organs were used to assess the safety level of the stem bark extract. The stem bark extract had more phytochemicals and better antioxidant activities compared with the leaf extract and oil. Administration of the stem bark extract did not result in treatment related changes in markers for hepatic and renal injury (aspartate transaminase, alanine transaminase, total protein, albumin, globulin, creatinine and urea). The extract resulted in an increase in hepatic malondialdehyde. Also, hepatic and renal glutathione levels increased significantly. The blood composition was normal and the genes coding for albumin in the liver together with catalase in the liver and kidney were up-regulated. Tumor necrosis factor – alpha (TNFα) gene expression was down-regulated in the liver and up-regulated in the kidney while KIM-1 gene was down-regulated in the treated animals compared with the control. This study confirmed that A. floribunda's stem bark extract is richer in bioactive compounds than the leaf extract and seed oil. Furthermore, it is relatively safe to animals when used in moderate dose." @default.
• W3194290807 created "2021-08-30" @default.
• W3194290807 creator A5003605367 @default.
• W3194290807 creator A5013729265 @default.
• W3194290807 creator A5055144816 @default.
• W3194290807 creator A5068751312 @default.
• W3194290807 creator A5089643617 @default.
• W3194290807 date "2021-09-01" @default.
• W3194290807 modified "2023-09-27" @default.
• W3194290807 title "Biological activity and subchronic toxicity study of Allanblackia floribunda Oliv. on experimental rats" @default.
• W3194290807 cites W1532672888 @default.
• W3194290807 cites W1863778363 @default.
• W3194290807 cites W1964405385 @default.
• W3194290807 cites W1964574933 @default.
• W3194290807 cites W1991635559 @default.
• W3194290807 cites W1996857551 @default.
• W3194290807 cites W2002061575 @default.
• W3194290807 cites W2002384775 @default.
• W3194290807 cites W2006670683 @default.
• W3194290807 cites W2030749349 @default.
• W3194290807 cites W2051142023 @default.
• W3194290807 cites W2055350407 @default.
• W3194290807 cites W2065853716 @default.
• W3194290807 cites W2077013120 @default.
• W3194290807 cites W2090703365 @default.
• W3194290807 cites W2104209550 @default.
• W3194290807 cites W2129365218 @default.
• W3194290807 cites W2129932301 @default.
• W3194290807 cites W2171968926 @default.
• W3194290807 cites W2263023695 @default.
• W3194290807 cites W2899052178 @default.
• W3194290807 cites W3037596952 @default.
• W3194290807 cites W307787372 @default.
• W3194290807 doi "https://doi.org/10.1016/j.sciaf.2021.e00950" @default.
• W3194290807 hasPublicationYear "2021" @default.
• W3194290807 type Work @default.
• W3194290807 sameAs 3194290807 @default.
• W3194290807 citedByCount "0" @default.
• W3194290807 crossrefType "journal-article" @default.
• W3194290807 hasAuthorship W3194290807A5003605367 @default.
• W3194290807 hasAuthorship W3194290807A5013729265 @default.
• W3194290807 hasAuthorship W3194290807A5055144816 @default.
• W3194290807 hasAuthorship W3194290807A5068751312 @default.
• W3194290807 hasAuthorship W3194290807A5089643617 @default.
• W3194290807 hasBestOaLocation W31942908071 @default.
• W3194290807 hasConcept C126322002 @default.
• W3194290807 hasConcept C134018914 @default.
• W3194290807 hasConcept C160160445 @default.
• W3194290807 hasConcept C181199279 @default.
• W3194290807 hasConcept C2776125364 @default.
• W3194290807 hasConcept C2776637226 @default.
• W3194290807 hasConcept C2778606649 @default.
• W3194290807 hasConcept C2779679107 @default.
• W3194290807 hasConcept C2780306776 @default.
• W3194290807 hasConcept C29730261 @default.
• W3194290807 hasConcept C55493867 @default.
• W3194290807 hasConcept C556039675 @default.
• W3194290807 hasConcept C71924100 @default.
• W3194290807 hasConcept C86803240 @default.
• W3194290807 hasConcept C98274493 @default.
• W3194290807 hasConceptScore W3194290807C126322002 @default.
• W3194290807 hasConceptScore W3194290807C134018914 @default.
• W3194290807 hasConceptScore W3194290807C160160445 @default.
• W3194290807 hasConceptScore W3194290807C181199279 @default.
• W3194290807 hasConceptScore W3194290807C2776125364 @default.
• W3194290807 hasConceptScore W3194290807C2776637226 @default.
• W3194290807 hasConceptScore W3194290807C2778606649 @default.
• W3194290807 hasConceptScore W3194290807C2779679107 @default.
• W3194290807 hasConceptScore W3194290807C2780306776 @default.
• W3194290807 hasConceptScore W3194290807C29730261 @default.
• W3194290807 hasConceptScore W3194290807C55493867 @default.
• W3194290807 hasConceptScore W3194290807C556039675 @default.
• W3194290807 hasConceptScore W3194290807C71924100 @default.
• W3194290807 hasConceptScore W3194290807C86803240 @default.
• W3194290807 hasConceptScore W3194290807C98274493 @default.
• W3194290807 hasLocation W31942908071 @default.
• W3194290807 hasOpenAccess W3194290807 @default.
• W3194290807 hasPrimaryLocation W31942908071 @default.
• W3194290807 hasRelatedWork W100021 @default.
• W3194290807 hasRelatedWork W11918801 @default.
• W3194290807 hasRelatedWork W1641019 @default.
• W3194290807 hasRelatedWork W17355599 @default.
• W3194290807 hasRelatedWork W18510784 @default.
• W3194290807 hasRelatedWork W3251753 @default.
• W3194290807 hasRelatedWork W3469505 @default.
• W3194290807 hasRelatedWork W6932960 @default.
• W3194290807 hasRelatedWork W7987689 @default.
• W3194290807 hasRelatedWork W8986928 @default.
• W3194290807 hasVolume "13" @default.
• W3194290807 isParatext "false" @default.
• W3194290807 isRetracted "false" @default.
• W3194290807 magId "3194290807" @default.
• W3194290807 workType "article" @default.