Matches in SemOpenAlex for { <https://semopenalex.org/work/W3194329608> ?p ?o ?g. }
- W3194329608 endingPage "194" @default.
- W3194329608 startingPage "151" @default.
- W3194329608 abstract "The acetylation/acylation (ac(et)ylation) of lysine side chains is a dynamic post-translational modification (PTM) regulating fundamental cellular processes with implications on the organisms' ageing process: metabolism, transcription, translation, cell proliferation, regulation of the cytoskeleton and DNA damage repair. First identified to occur on histones, later studies revealed the presence of lysine ac(et)ylation in organisms of all kingdoms of life, in proteins covering all essential cellular processes. A remarkable finding showed that the NAD+-dependent sirtuin deacetylase Sir2 has an impact on replicative lifespan in Saccharomyces cerevisiae suggesting that lysine acetylation has a direct role in the ageing process. Later studies identified sirtuins as mediators for beneficial effects of caloric/dietary restriction on the organisms' health- or lifespan. However, the molecular mechanisms underlying these effects are only incompletely understood. Progress in mass-spectrometry, structural biology, synthetic and semi-synthetic biology deepened our understanding of this PTM. This review summarizes recent developments in the research field. It shows how lysine ac(et)ylation regulates protein function, how it is regulated enzymatically and non-enzymatically, how a dysfunction in this post-translational machinery contributes to disease development. A focus is set on sirtuins and lysine acyltransferases as these are direct sensors and mediators of the cellular metabolic state. Finally, this review highlights technological advances to study lysine ac(et)ylation." @default.
- W3194329608 created "2021-08-30" @default.
- W3194329608 creator A5015309073 @default.
- W3194329608 creator A5033846293 @default.
- W3194329608 creator A5056599013 @default.
- W3194329608 creator A5059157757 @default.
- W3194329608 creator A5070871031 @default.
- W3194329608 creator A5085382164 @default.
- W3194329608 date "2021-08-23" @default.
- W3194329608 modified "2023-10-14" @default.
- W3194329608 title "Post-translational lysine ac(et)ylation in health, ageing and disease" @default.
- W3194329608 cites W143544902 @default.
- W3194329608 cites W1483663613 @default.
- W3194329608 cites W1491563504 @default.
- W3194329608 cites W1523349613 @default.
- W3194329608 cites W1526798002 @default.
- W3194329608 cites W1535940973 @default.
- W3194329608 cites W1545698323 @default.
- W3194329608 cites W1553155385 @default.
- W3194329608 cites W1557519235 @default.
- W3194329608 cites W1601563420 @default.
- W3194329608 cites W1625510017 @default.
- W3194329608 cites W1762535185 @default.
- W3194329608 cites W1792088282 @default.
- W3194329608 cites W1803373824 @default.
- W3194329608 cites W1815058574 @default.
- W3194329608 cites W18353697 @default.
- W3194329608 cites W1854830230 @default.
- W3194329608 cites W1862685904 @default.
- W3194329608 cites W1916665120 @default.
- W3194329608 cites W1917876135 @default.
- W3194329608 cites W1959721425 @default.
- W3194329608 cites W196082105 @default.
- W3194329608 cites W1964059126 @default.
- W3194329608 cites W1964866948 @default.
- W3194329608 cites W1965488403 @default.
- W3194329608 cites W1966437575 @default.
- W3194329608 cites W1966868505 @default.
- W3194329608 cites W1968058162 @default.
- W3194329608 cites W1970367686 @default.
- W3194329608 cites W1970743827 @default.
- W3194329608 cites W1971407164 @default.
- W3194329608 cites W1972149587 @default.
- W3194329608 cites W1973639948 @default.
- W3194329608 cites W1974112332 @default.
- W3194329608 cites W1975692560 @default.
- W3194329608 cites W1976033223 @default.
- W3194329608 cites W1976059452 @default.
- W3194329608 cites W1977014064 @default.
- W3194329608 cites W1977622464 @default.
- W3194329608 cites W1979745754 @default.
- W3194329608 cites W1980268323 @default.
- W3194329608 cites W1981259598 @default.
- W3194329608 cites W1981673436 @default.
- W3194329608 cites W1982126966 @default.
- W3194329608 cites W1983246137 @default.
- W3194329608 cites W1984658022 @default.
- W3194329608 cites W1985834536 @default.
- W3194329608 cites W1987909353 @default.
- W3194329608 cites W1989029565 @default.
- W3194329608 cites W1989763558 @default.
- W3194329608 cites W1989809800 @default.
- W3194329608 cites W1990011854 @default.
- W3194329608 cites W1990174038 @default.
- W3194329608 cites W1991876528 @default.
- W3194329608 cites W1992318497 @default.
- W3194329608 cites W1993967951 @default.
- W3194329608 cites W1994540097 @default.
- W3194329608 cites W1998344552 @default.
- W3194329608 cites W2003155232 @default.
- W3194329608 cites W2005723902 @default.
- W3194329608 cites W2005789183 @default.
- W3194329608 cites W2007527830 @default.
- W3194329608 cites W2007666596 @default.
- W3194329608 cites W2008887287 @default.
- W3194329608 cites W2009826707 @default.
- W3194329608 cites W2009835795 @default.
- W3194329608 cites W2009949436 @default.
- W3194329608 cites W2009954700 @default.
- W3194329608 cites W2010394540 @default.
- W3194329608 cites W2015398239 @default.
- W3194329608 cites W2015857899 @default.
- W3194329608 cites W2016012641 @default.
- W3194329608 cites W2017297735 @default.
- W3194329608 cites W2018463433 @default.
- W3194329608 cites W2018739566 @default.
- W3194329608 cites W2022051395 @default.
- W3194329608 cites W2022267544 @default.
- W3194329608 cites W2022767678 @default.
- W3194329608 cites W2023871611 @default.
- W3194329608 cites W2024551271 @default.
- W3194329608 cites W2024961648 @default.
- W3194329608 cites W2025827248 @default.
- W3194329608 cites W2026576443 @default.
- W3194329608 cites W2027298044 @default.
- W3194329608 cites W2029130907 @default.
- W3194329608 cites W2029609230 @default.
- W3194329608 cites W2029903254 @default.