Matches in SemOpenAlex for { <https://semopenalex.org/work/W3194332023> ?p ?o ?g. }
- W3194332023 endingPage "121097" @default.
- W3194332023 startingPage "121097" @default.
- W3194332023 abstract "Skeletal muscle tissue is mechanically dynamic with changes in stiffness influencing function, maintenance, and regeneration. We modeled skeletal muscle mechanical changes in culture with dynamically stiffening hydrogels demonstrating that the chaperone protein BAG3 transduces matrix stiffness by redistributing YAP and TAZ subcellular localization in muscle progenitor cells. BAG3 depletion increases cytoplasmic retention of YAP and TAZ, desensitizing myoblasts to changes in hydrogel elastic moduli. Upon differentiation, muscle progenitors depleted of BAG3 formed enlarged, round myotubes lacking the typical cylindrical morphology. The aberrant morphology is dependent on YAP/TAZ signaling, which was sequestered in the cytoplasm in BAG3-depleted myotubes but predominately nuclear in cylindrical myotubes of control cells. Control progenitor cells induced to differentiate on soft (E' = 4 and 12 kPa) hydrogels formed circular myotubes similar to those observed in BAG3-depleted cells. Inhibition of the Hippo pathway partially restored myotube morphologies, permitting nuclear translocation of YAP and TAZ in BAG3-depleted myogenic progenitors. Thus, BAG3 is a critical mediator of dynamic stiffness changes in muscle tissue, coupling mechanical alterations to intracellular signals and inducing changes in gene expression that influence muscle progenitor cell morphology and differentiation." @default.
- W3194332023 created "2021-08-30" @default.
- W3194332023 creator A5023068045 @default.
- W3194332023 creator A5035320964 @default.
- W3194332023 creator A5036782839 @default.
- W3194332023 creator A5036949658 @default.
- W3194332023 creator A5058134895 @default.
- W3194332023 creator A5062572308 @default.
- W3194332023 creator A5072286545 @default.
- W3194332023 creator A5090551098 @default.
- W3194332023 date "2021-10-01" @default.
- W3194332023 modified "2023-10-14" @default.
- W3194332023 title "Myoblast mechanotransduction and myotube morphology is dependent on BAG3 regulation of YAP and TAZ" @default.
- W3194332023 cites W1152185354 @default.
- W3194332023 cites W1578871194 @default.
- W3194332023 cites W1598397366 @default.
- W3194332023 cites W1825669598 @default.
- W3194332023 cites W1968222033 @default.
- W3194332023 cites W1970944947 @default.
- W3194332023 cites W1990922120 @default.
- W3194332023 cites W2000121424 @default.
- W3194332023 cites W2004754771 @default.
- W3194332023 cites W2009128541 @default.
- W3194332023 cites W2013006994 @default.
- W3194332023 cites W2018956321 @default.
- W3194332023 cites W2030233835 @default.
- W3194332023 cites W2038845044 @default.
- W3194332023 cites W2052003710 @default.
- W3194332023 cites W2052533825 @default.
- W3194332023 cites W2056331158 @default.
- W3194332023 cites W2058310958 @default.
- W3194332023 cites W2061058076 @default.
- W3194332023 cites W2067897176 @default.
- W3194332023 cites W2069977719 @default.
- W3194332023 cites W2089375954 @default.
- W3194332023 cites W2097304128 @default.
- W3194332023 cites W2097905561 @default.
- W3194332023 cites W2145163771 @default.
- W3194332023 cites W2146337514 @default.
- W3194332023 cites W2167243609 @default.
- W3194332023 cites W2223413920 @default.
- W3194332023 cites W2280422486 @default.
- W3194332023 cites W2290648886 @default.
- W3194332023 cites W2330373241 @default.
- W3194332023 cites W2344920256 @default.
- W3194332023 cites W2345399459 @default.
- W3194332023 cites W2405928886 @default.
- W3194332023 cites W2503067859 @default.
- W3194332023 cites W2512544075 @default.
- W3194332023 cites W2580802821 @default.
- W3194332023 cites W2593876335 @default.
- W3194332023 cites W2601343417 @default.
- W3194332023 cites W2745424666 @default.
- W3194332023 cites W2746160416 @default.
- W3194332023 cites W2752873907 @default.
- W3194332023 cites W2758838459 @default.
- W3194332023 cites W2766231632 @default.
- W3194332023 cites W2795906582 @default.
- W3194332023 cites W2804041046 @default.
- W3194332023 cites W2829023813 @default.
- W3194332023 cites W2888628838 @default.
- W3194332023 cites W2891230587 @default.
- W3194332023 cites W2945104507 @default.
- W3194332023 cites W2946518848 @default.
- W3194332023 cites W2963969560 @default.
- W3194332023 cites W2982342780 @default.
- W3194332023 cites W3032290637 @default.
- W3194332023 cites W3135542256 @default.
- W3194332023 doi "https://doi.org/10.1016/j.biomaterials.2021.121097" @default.
- W3194332023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8478876" @default.
- W3194332023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34481290" @default.
- W3194332023 hasPublicationYear "2021" @default.
- W3194332023 type Work @default.
- W3194332023 sameAs 3194332023 @default.
- W3194332023 citedByCount "8" @default.
- W3194332023 countsByYear W31943320232022 @default.
- W3194332023 countsByYear W31943320232023 @default.
- W3194332023 crossrefType "journal-article" @default.
- W3194332023 hasAuthorship W3194332023A5023068045 @default.
- W3194332023 hasAuthorship W3194332023A5035320964 @default.
- W3194332023 hasAuthorship W3194332023A5036782839 @default.
- W3194332023 hasAuthorship W3194332023A5036949658 @default.
- W3194332023 hasAuthorship W3194332023A5058134895 @default.
- W3194332023 hasAuthorship W3194332023A5062572308 @default.
- W3194332023 hasAuthorship W3194332023A5072286545 @default.
- W3194332023 hasAuthorship W3194332023A5090551098 @default.
- W3194332023 hasBestOaLocation W31943320231 @default.
- W3194332023 hasConcept C181104049 @default.
- W3194332023 hasConcept C190283241 @default.
- W3194332023 hasConcept C201750760 @default.
- W3194332023 hasConcept C203522944 @default.
- W3194332023 hasConcept C207200792 @default.
- W3194332023 hasConcept C28328180 @default.
- W3194332023 hasConcept C3763915 @default.
- W3194332023 hasConcept C55493867 @default.
- W3194332023 hasConcept C86803240 @default.
- W3194332023 hasConcept C95444343 @default.
- W3194332023 hasConcept C99089365 @default.