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• W3194401190 endingPage "107502" @default.
• W3194401190 startingPage "107502" @default.
• W3194401190 abstract "Insight into the molecular and cellular mechanisms of learning and memory from a diverse array of taxa contributes to our understanding of the evolution of these processes. The fire-bellied toad, Bombina orientalis, is a basal anuran amphibian model species who could help us describe shared and divergent characteristics of learning and memory mechanisms between amphibians and other vertebrates, and hence answer questions about the evolution of learning. Utilizing next generation sequencing techniques, we profiled gene expression patterns associated with the extinction of prey-catching conditioning in the brain of the fire-bellied toad. For this purpose, gene expression was at first compared between toads sacrificed after acquisition and extinction of the conditioned response. A second comparison was done between toads submitted to extinction following either short or long acquisition training, which results in toads displaying response extinction or resistance to extinction, respectively. We analyzed brain tissue transcription profiles common to both acquisition and extinction learning, or unique to extinction learning and resistance to extinction, and found significant overlap in gene expression related to molecular pathways involving neuronal plasticity (e.g. structural modification, transcription). However, extinction learning induced a unique GABAergic transcriptomic signal, which may be responsible for suppression of the original response memory. Further, when comparing extinction learning in short- and long-trained groups, short training engaged many pathways related to neuronal plasticity, as expected, but long training engaged molecular pathways related to the suppression of learning through epigenetic mediated transcriptional suppression and inhibitory neurotransmission. Overall, gene expression patterns associated with extinction learning in the fire-bellied toad were similar to those found in mammals submitted to extinction, although some divergent profiles highlighted potential differences in the mechanisms of learning and memory among tetrapods." @default.
• W3194401190 created "2021-08-30" @default.
• W3194401190 creator A5005967987 @default.
• W3194401190 creator A5022651202 @default.
• W3194401190 creator A5078960419 @default.
• W3194401190 date "2021-10-01" @default.
• W3194401190 modified "2023-10-12" @default.
• W3194401190 title "Transcriptomic signature of extinction learning in the brain of the fire-bellied toad, Bombina orientalis" @default.
• W3194401190 cites W1557080778 @default.
• W3194401190 cites W1608785134 @default.
• W3194401190 cites W1846766371 @default.
• W3194401190 cites W1959821071 @default.
• W3194401190 cites W1966846181 @default.
• W3194401190 cites W1968091973 @default.
• W3194401190 cites W1969202258 @default.
• W3194401190 cites W1969301568 @default.
• W3194401190 cites W1972235413 @default.
• W3194401190 cites W1972504466 @default.
• W3194401190 cites W1978830637 @default.
• W3194401190 cites W1978972961 @default.
• W3194401190 cites W1984393730 @default.
• W3194401190 cites W1988512056 @default.
• W3194401190 cites W1990276186 @default.
• W3194401190 cites W1990293955 @default.
• W3194401190 cites W1990582382 @default.
• W3194401190 cites W1990596134 @default.
• W3194401190 cites W1993690326 @default.
• W3194401190 cites W1995629399 @default.
• W3194401190 cites W1996243898 @default.
• W3194401190 cites W2001355136 @default.
• W3194401190 cites W2001536896 @default.
• W3194401190 cites W2003070434 @default.
• W3194401190 cites W2005032743 @default.
• W3194401190 cites W2006848427 @default.
• W3194401190 cites W2009041030 @default.
• W3194401190 cites W2010863207 @default.
• W3194401190 cites W2011657487 @default.
• W3194401190 cites W2012639972 @default.
• W3194401190 cites W2014826652 @default.
• W3194401190 cites W2014840991 @default.
• W3194401190 cites W2015285707 @default.
• W3194401190 cites W2016858872 @default.
• W3194401190 cites W2018346570 @default.
• W3194401190 cites W2020273146 @default.
• W3194401190 cites W2020616048 @default.
• W3194401190 cites W2021213423 @default.
• W3194401190 cites W2026609418 @default.
• W3194401190 cites W2035341085 @default.
• W3194401190 cites W2037185569 @default.
• W3194401190 cites W2037973854 @default.
• W3194401190 cites W2038938389 @default.
• W3194401190 cites W2040392501 @default.
• W3194401190 cites W2043662856 @default.
• W3194401190 cites W2050066016 @default.
• W3194401190 cites W2050318176 @default.
• W3194401190 cites W2055043387 @default.
• W3194401190 cites W2059249241 @default.
• W3194401190 cites W2059928135 @default.
• W3194401190 cites W2065042047 @default.
• W3194401190 cites W2065357806 @default.
• W3194401190 cites W2070785687 @default.
• W3194401190 cites W2072131973 @default.
• W3194401190 cites W2077452637 @default.
• W3194401190 cites W2079809211 @default.
• W3194401190 cites W2086830518 @default.
• W3194401190 cites W2092157685 @default.
• W3194401190 cites W2097864389 @default.
• W3194401190 cites W2101175098 @default.
• W3194401190 cites W2103791867 @default.
• W3194401190 cites W2104484136 @default.
• W3194401190 cites W2106100119 @default.
• W3194401190 cites W2106342289 @default.
• W3194401190 cites W2110724392 @default.
• W3194401190 cites W2117820491 @default.
• W3194401190 cites W2120087253 @default.
• W3194401190 cites W2131359219 @default.
• W3194401190 cites W2131904148 @default.
• W3194401190 cites W2136652273 @default.
• W3194401190 cites W2137116499 @default.
• W3194401190 cites W2140317427 @default.
• W3194401190 cites W2142678478 @default.
• W3194401190 cites W2150718243 @default.
• W3194401190 cites W2151571360 @default.
• W3194401190 cites W2158217645 @default.
• W3194401190 cites W2159010352 @default.
• W3194401190 cites W2163500926 @default.
• W3194401190 cites W2170551349 @default.
• W3194401190 cites W2179438025 @default.
• W3194401190 cites W2224527671 @default.
• W3194401190 cites W2236822143 @default.
• W3194401190 cites W2244665647 @default.
• W3194401190 cites W2305855711 @default.
• W3194401190 cites W2330367278 @default.
• W3194401190 cites W2342876757 @default.
• W3194401190 cites W2412500251 @default.
• W3194401190 cites W243364712 @default.
• W3194401190 cites W2552100732 @default.
• W3194401190 cites W2560264773 @default.

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