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- W3194420595 endingPage "4263" @default.
- W3194420595 startingPage "4263" @default.
- W3194420595 abstract "The discovery of immune checkpoints provided a breakthrough for cancer therapy. Immune checkpoints are inhibitory receptors that are up-regulated on chronically stimulated lymphocytes and have been shown to hinder immune responses to cancer. Monoclonal antibodies against the checkpoint molecules PD-1 and CTLA-4 have shown early clinical success against melanoma and are now approved to treat various cancers. Since then, the list of potential candidates for immune checkpoint blockade has dramatically increased. The current paradigm stipulates that immune checkpoint blockade therapy unleashes pre-existing T cell responses. However, there is accumulating evidence that some of these immune checkpoint molecules are also expressed on Natural Killer (NK) cells. In this review, we summarize our latest knowledge about targetable NK cell inhibitory receptors. We discuss the HLA-binding receptors KIRS and NKG2A, receptors binding to nectin and nectin-like molecules including TIGIT, CD96, and CD112R, and immune checkpoints commonly associated with T cells such as PD-1, TIM-3, and LAG-3. We also discuss newly discovered pathways such as IL-1R8 and often overlooked receptors such as CD161 and Siglecs. We detail how these inhibitory receptors might regulate NK cell responses to cancer, and, where relevant, we discuss their implications for therapeutic intervention." @default.
- W3194420595 created "2021-08-30" @default.
- W3194420595 creator A5047386670 @default.
- W3194420595 creator A5066228624 @default.
- W3194420595 date "2021-08-24" @default.
- W3194420595 modified "2023-10-16" @default.
- W3194420595 title "Inhibitory Receptors and Immune Checkpoints Regulating Natural Killer Cell Responses to Cancer" @default.
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