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- W3194426002 abstract "Plaque psoriasis is a common inflammatory condition of the skin characterized by red, flaking lesions. Current therapies for plaque psoriasis target many facets of the autoimmune response, but there is an incomplete understanding of how oxidative damage produced by enzymes such as myeloperoxidase contributes to skin pathology. In this study, we used the Aldara (Imiquimod) cream model of plaque psoriasis in mice to assess myeloperoxidase inhibition for treating psoriatic skin lesions. To assess skin inflammation severity, an innovative mouse psoriasis scoring system was developed. We found that myeloperoxidase inhibition ameliorated psoriasis severity when administered either systemically or topically. The findings of this study support the role of oxidative damage in plaque psoriasis pathology and present potential new therapeutic avenues for further exploration." @default.
- W3194426002 created "2021-08-30" @default.
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- W3194426002 date "2021-08-25" @default.
- W3194426002 modified "2023-10-15" @default.
- W3194426002 title "Myeloperoxidase Inhibition Ameliorates Plaque Psoriasis in Mice" @default.
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- W3194426002 doi "https://doi.org/10.3390/antiox10091338" @default.
- W3194426002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8472607" @default.
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