Matches in SemOpenAlex for { <https://semopenalex.org/work/W3194477778> ?p ?o ?g. }
- W3194477778 endingPage "667" @default.
- W3194477778 startingPage "667" @default.
- W3194477778 abstract "Candida glabrata is a yeast of increasing medical relevance, particularly in critically ill patients. It is the second most isolated Candida species associated with invasive candidiasis (IC) behind C. albicans. The attributed higher incidence is primarily due to an increase in the acquired immunodeficiency syndrome (AIDS) population, cancer, and diabetic patients. The elderly population and the frequent use of indwelling medical devices are also predisposing factors. This work aimed to review various virulence factors that facilitate the survival of pathogenic C. glabrata in IC. The available published research articles related to the pathogenicity of C. glabrata were retrieved and reviewed from four credible databases, mainly Google Scholar, ScienceDirect, PubMed, and Scopus. The articles highlighted many virulence factors associated with pathogenicity in C. glabrata, including adherence to susceptible host surfaces, evading host defences, replicative ageing, and producing hydrolytic enzymes (e.g., phospholipases, proteases, and haemolysins). The factors facilitate infection initiation. Other virulent factors include iron regulation and genetic mutations. Accordingly, biofilm production, tolerance to high-stress environments, resistance to neutrophil killings, and development of resistance to antifungal drugs, notably to fluconazole and other azole derivatives, were reported. The review provided evident pathogenic mechanisms and antifungal resistance associated with C. glabrata in ensuring its sustenance and survival." @default.
- W3194477778 created "2021-08-30" @default.
- W3194477778 creator A5011307668 @default.
- W3194477778 creator A5019278703 @default.
- W3194477778 creator A5049747832 @default.
- W3194477778 date "2021-08-17" @default.
- W3194477778 modified "2023-10-11" @default.
- W3194477778 title "Candida glabrata: Pathogenicity and Resistance Mechanisms for Adaptation and Survival" @default.
- W3194477778 cites W1646933696 @default.
- W3194477778 cites W1821298691 @default.
- W3194477778 cites W1881372541 @default.
- W3194477778 cites W1884430856 @default.
- W3194477778 cites W1903085608 @default.
- W3194477778 cites W1941779326 @default.
- W3194477778 cites W1976891952 @default.
- W3194477778 cites W1982281067 @default.
- W3194477778 cites W1985593560 @default.
- W3194477778 cites W1987360980 @default.
- W3194477778 cites W1990892595 @default.
- W3194477778 cites W2006141070 @default.
- W3194477778 cites W2013756061 @default.
- W3194477778 cites W2019147818 @default.
- W3194477778 cites W2022006512 @default.
- W3194477778 cites W2023124600 @default.
- W3194477778 cites W2038113654 @default.
- W3194477778 cites W2041296708 @default.
- W3194477778 cites W2042241151 @default.
- W3194477778 cites W2054716142 @default.
- W3194477778 cites W2056278758 @default.
- W3194477778 cites W2067631595 @default.
- W3194477778 cites W2080201761 @default.
- W3194477778 cites W2083402253 @default.
- W3194477778 cites W2086378149 @default.
- W3194477778 cites W2088309256 @default.
- W3194477778 cites W2098166370 @default.
- W3194477778 cites W2098964280 @default.
- W3194477778 cites W2105649156 @default.
- W3194477778 cites W2110892287 @default.
- W3194477778 cites W2114012147 @default.
- W3194477778 cites W2119570364 @default.
- W3194477778 cites W2119797129 @default.
- W3194477778 cites W2120930467 @default.
- W3194477778 cites W2133094979 @default.
- W3194477778 cites W2135964955 @default.
- W3194477778 cites W2138412094 @default.
- W3194477778 cites W2140189533 @default.
- W3194477778 cites W2141563676 @default.
- W3194477778 cites W2152062473 @default.
- W3194477778 cites W2155403267 @default.
- W3194477778 cites W2157490841 @default.
- W3194477778 cites W2169476905 @default.
- W3194477778 cites W2172448890 @default.
- W3194477778 cites W2196963808 @default.
- W3194477778 cites W2211508526 @default.
- W3194477778 cites W2216779599 @default.
- W3194477778 cites W2234993746 @default.
- W3194477778 cites W2280986000 @default.
- W3194477778 cites W2284331280 @default.
- W3194477778 cites W2338841684 @default.
- W3194477778 cites W2415504847 @default.
- W3194477778 cites W2417167887 @default.
- W3194477778 cites W2522397107 @default.
- W3194477778 cites W2525511112 @default.
- W3194477778 cites W2530772399 @default.
- W3194477778 cites W2531300932 @default.
- W3194477778 cites W2535674819 @default.
- W3194477778 cites W2539183997 @default.
- W3194477778 cites W2559157861 @default.
- W3194477778 cites W2574417950 @default.
- W3194477778 cites W2602044155 @default.
- W3194477778 cites W2603290438 @default.
- W3194477778 cites W2608783038 @default.
- W3194477778 cites W2613639508 @default.
- W3194477778 cites W2623604452 @default.
- W3194477778 cites W2678224484 @default.
- W3194477778 cites W2739674022 @default.
- W3194477778 cites W2750959598 @default.
- W3194477778 cites W2757471205 @default.
- W3194477778 cites W2758571492 @default.
- W3194477778 cites W2765742851 @default.
- W3194477778 cites W2767781708 @default.
- W3194477778 cites W2769719637 @default.
- W3194477778 cites W2769974987 @default.
- W3194477778 cites W2779194960 @default.
- W3194477778 cites W2781618508 @default.
- W3194477778 cites W2782285131 @default.
- W3194477778 cites W2782643503 @default.
- W3194477778 cites W2783389157 @default.
- W3194477778 cites W2785569026 @default.
- W3194477778 cites W2785998129 @default.
- W3194477778 cites W2788398173 @default.
- W3194477778 cites W2790728643 @default.
- W3194477778 cites W2794954013 @default.
- W3194477778 cites W2801279350 @default.
- W3194477778 cites W2803879256 @default.
- W3194477778 cites W2806463970 @default.
- W3194477778 cites W2807385290 @default.
- W3194477778 cites W2890319039 @default.