Matches in SemOpenAlex for { <https://semopenalex.org/work/W3194479905> ?p ?o ?g. }
- W3194479905 endingPage "1791" @default.
- W3194479905 startingPage "1755" @default.
- W3194479905 abstract "Several studies have reported the health-beneficial effects of dietary phytochemicals, namely polyphenols, to prevent various diseases, including cancer. Polyphenols, like (-)-epigallocatechin-3-gallate (EGCG) from green tea, curcumin from turmeric, and ellagic acid from pomegranate are known to act by modulating antioxidant, anti-inflammatory and apoptotic signal transduction pathways in the tumor milieu. The evolving literature underscores the role of epigenetic regulation of genes associated with cancer by these polyphenols, primarily via non-coding RNAs (ncRNAs), such as microRNAs (miRNA) and long noncoding RNA (lncRNA). However, there is little clarity on the exact role(s) played by these ncRNAs and their interactions with other ncRNAs, or with their protein targets, in response to modulation by these dietary polyphenols. Here, we review ncRNA interactions and functional networks of the complex ncRNA interactome with their targets in preclinical studies along with the role of epigenetics as well as key aspects of pharmacokinetics and phytochemistry of dietary polyphenols. We also summarize the current state of clinical trials with these dietary polyphenols. Taken together, this synthetic review provides insights into the molecular aspects underlying the anticancer chemopreventive effects of dietary polyphenols as well as summarizes data on novel biomarkers modulated by these polyphenols for preventive or therapeutic purposes in various types of cancer." @default.
- W3194479905 created "2021-08-30" @default.
- W3194479905 creator A5000757163 @default.
- W3194479905 creator A5050947683 @default.
- W3194479905 creator A5060469200 @default.
- W3194479905 creator A5070419576 @default.
- W3194479905 creator A5072744276 @default.
- W3194479905 creator A5074800193 @default.
- W3194479905 date "2021-08-26" @default.
- W3194479905 modified "2023-10-16" @default.
- W3194479905 title "Current insights into epigenetics, noncoding RNA interactome and clinical pharmacokinetics of dietary polyphenols in cancer chemoprevention" @default.
- W3194479905 cites W1258584912 @default.
- W3194479905 cites W1517858579 @default.
- W3194479905 cites W1588145958 @default.
- W3194479905 cites W1604068141 @default.
- W3194479905 cites W1766445465 @default.
- W3194479905 cites W1799835945 @default.
- W3194479905 cites W1914148979 @default.
- W3194479905 cites W1969257164 @default.
- W3194479905 cites W1969601405 @default.
- W3194479905 cites W1974290383 @default.
- W3194479905 cites W1976194786 @default.
- W3194479905 cites W1977191081 @default.
- W3194479905 cites W1980236411 @default.
- W3194479905 cites W1980531351 @default.
- W3194479905 cites W1984358846 @default.
- W3194479905 cites W1996044502 @default.
- W3194479905 cites W2000248590 @default.
- W3194479905 cites W2007108460 @default.
- W3194479905 cites W2007804755 @default.
- W3194479905 cites W2008382270 @default.
- W3194479905 cites W2010120018 @default.
- W3194479905 cites W2022026491 @default.
- W3194479905 cites W2032443100 @default.
- W3194479905 cites W2033143975 @default.
- W3194479905 cites W2034123367 @default.
- W3194479905 cites W2036907967 @default.
- W3194479905 cites W2041764058 @default.
- W3194479905 cites W2047475718 @default.
- W3194479905 cites W2055025559 @default.
- W3194479905 cites W2057899102 @default.
- W3194479905 cites W2065887130 @default.
- W3194479905 cites W2072652027 @default.
- W3194479905 cites W2076279319 @default.
- W3194479905 cites W2077166822 @default.
- W3194479905 cites W2077170410 @default.
- W3194479905 cites W2079847552 @default.
- W3194479905 cites W2083361874 @default.
- W3194479905 cites W2085543440 @default.
- W3194479905 cites W2092032160 @default.
- W3194479905 cites W2095569714 @default.
- W3194479905 cites W2101072227 @default.
- W3194479905 cites W2101546285 @default.
- W3194479905 cites W2113755029 @default.
- W3194479905 cites W2114373278 @default.
- W3194479905 cites W2119944195 @default.
- W3194479905 cites W2132182488 @default.
- W3194479905 cites W2132209554 @default.
- W3194479905 cites W2138508372 @default.
- W3194479905 cites W2142673449 @default.
- W3194479905 cites W2143526116 @default.
- W3194479905 cites W2144095756 @default.
- W3194479905 cites W2145418093 @default.
- W3194479905 cites W2146546535 @default.
- W3194479905 cites W2151101177 @default.
- W3194479905 cites W2153661117 @default.
- W3194479905 cites W2153663340 @default.
- W3194479905 cites W2154748960 @default.
- W3194479905 cites W2159109910 @default.
- W3194479905 cites W2161349049 @default.
- W3194479905 cites W2195412558 @default.
- W3194479905 cites W2267215259 @default.
- W3194479905 cites W2289315746 @default.
- W3194479905 cites W2314489732 @default.
- W3194479905 cites W2320853052 @default.
- W3194479905 cites W2322316999 @default.
- W3194479905 cites W2323044652 @default.
- W3194479905 cites W2323737924 @default.
- W3194479905 cites W2331772202 @default.
- W3194479905 cites W2336899573 @default.
- W3194479905 cites W2338602785 @default.
- W3194479905 cites W2401399517 @default.
- W3194479905 cites W2412650067 @default.
- W3194479905 cites W2415373535 @default.
- W3194479905 cites W2417060586 @default.
- W3194479905 cites W2433713077 @default.
- W3194479905 cites W2480957117 @default.
- W3194479905 cites W2483781252 @default.
- W3194479905 cites W2513414068 @default.
- W3194479905 cites W2520989666 @default.
- W3194479905 cites W2525935580 @default.
- W3194479905 cites W2530811934 @default.
- W3194479905 cites W2547035050 @default.
- W3194479905 cites W2555757312 @default.
- W3194479905 cites W2569912524 @default.
- W3194479905 cites W2580789786 @default.
- W3194479905 cites W2582017877 @default.
- W3194479905 cites W2587685360 @default.