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- W319458334 abstract "ABSTRACT High concentrations of L-glutamate (3–10 mM) evoked dopamine release from striatal slices that was Ca2+-independent and insensitive to both tetrodotoxin (0.5 μM) and reserpine (5 mg/kg, s.c). This response was inhibited by nomifensine (10 μM) or removing Na+, treatments that block high affinity dopamine uptake. In addition, dopamine (10 μM) produced [3H]GABA release which still occurred in the presence of SCH23390 (10 μM) or sulpiride (10 μM), dopamine receptor antagonists, but was abolished by nipecotic acid (100 μM), an inhibitor of GABA uptake. These results suggest that in certain cases neurotransmitter release can be evoked via a reversal of high affinity uptake systems as well as by classical mechanism of exocytosis." @default.
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- W319458334 date "1991-01-01" @default.
- W319458334 modified "2023-10-17" @default.
- W319458334 title "Transmitter Interactions in Striatum May Occur via Effects on High Affinity Transporters" @default.
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- W319458334 doi "https://doi.org/10.1016/b978-0-08-041165-1.50046-6" @default.
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