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• W3194629258 abstract "Aims We assessed whether oxidative stress (OS) is increased in children/adolescents with type 1 diabetes (T1D) compared to healthy peers. Moreover, we searched for OS predictors in the T1D population. Methods We compared the concentration of serum derivatives of reactive oxygen metabolites (d-ROMs) in 412 children/adolescents with T1D (3.6–23.5 years old) to that of 138 healthy children/adolescents (1.2–19.2 years old) by ANOVA adjusted for age, gender, and BMI z-score (z-BMI). Applying a general linear model, in a subgroup of 331 patients using continuous glucose monitoring, we searched for predictors of d-ROMs among 3-day, 2-week, and 4-week metrics of glucose control and variability, such as mean blood glucose, percent time in range (70–180 mg/dl,TIR70-180), coefficient of variation, and others, as well as among conventional cardiovascular risk factors like current and average HbA1c, z-BMI, blood pressure percentiles, and lipid concentrations recorded retrospectively over the entire follow-up period. Results D-ROMs levels were significantly higher in children/adolescents with T1D compared to controls [371.9 (64.2) versus 324.9 (46.3), p < 10−16]. Sex (B = 49.1, ƞ2 = 0.14, p = 1.3 * 10−9), age < 12 years in boys (B = 79.4, ƞ2 = 0.074, p = 10−7),3-day TIR70-180 (B = -0.87, ƞ2 = 0.048, p = 6.5 * 10−5), and z-BMI (B = 7.4, ƞ2 = 0.016, p = 0.022) predicted d-ROMs with an overall R2 of 0.278. Conclusions OS is increased in youth with T1D and only partially predicted by gender, age, glucose control, and anthropometry. Other potential determinants of OS in this population should be targeted in future studies." @default.
• W3194629258 created "2021-08-30" @default.
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• W3194629258 date "2021-09-01" @default.
• W3194629258 modified "2023-10-05" @default.
• W3194629258 title "Oxidative stress in youth with type 1 diabetes: Not only a matter of gender, age, and glycemic control" @default.
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• W3194629258 doi "https://doi.org/10.1016/j.diabres.2021.109007" @default.
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