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- W3194654317 endingPage "121087" @default.
- W3194654317 startingPage "121087" @default.
- W3194654317 abstract "Implantation of biomaterials and medical devices in the body triggers the foreign body reaction (FBR) which is characterized by macrophage fusion at the implant surface leading to the formation of foreign body giant cells and the development of the fibrous capsule enveloping the implant. While adhesion of macrophages to the surface is an essential step in macrophage fusion and implanted biomaterials are known to rapidly acquire a layer of host proteins, a biological substrate that is responsible for this process in vivo is unknown. Here we show that mice with genetically imposed fibrinogen deficiency display a dramatic reduction of macrophage fusion on biomaterials implanted intraperitoneally and subcutaneously and are protected from the formation of the fibrin-containing fibrous capsule. Furthermore, macrophage fusion on biomaterials implanted in FibAEK mice that express a mutated form of fibrinogen incapable of thrombin-mediated polymerization was strongly reduced. Despite the lack of fibrin, the capsule was formed in FibAEK mice, although it had a different composition and distinct mechanical properties than that in wild-type mice. Specifically, while mononuclear α-SMA-expressing macrophages embedded in the capsule of both strains of mice secreted collagen, the amount of collagen and its density in the tissue of FibAEK mice was reduced. These data identify fibrin polymer as a key biological substrate driving the development of the FBR." @default.
- W3194654317 created "2021-08-30" @default.
- W3194654317 creator A5014838127 @default.
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- W3194654317 creator A5086366311 @default.
- W3194654317 creator A5088091907 @default.
- W3194654317 date "2021-10-01" @default.
- W3194654317 modified "2023-10-17" @default.
- W3194654317 title "Fibrin polymer on the surface of biomaterial implants drives the foreign body reaction" @default.
- W3194654317 cites W140358616 @default.
- W3194654317 cites W1487373628 @default.
- W3194654317 cites W1507013396 @default.
- W3194654317 cites W1512506307 @default.
- W3194654317 cites W1785267653 @default.
- W3194654317 cites W1821635550 @default.
- W3194654317 cites W1950564172 @default.
- W3194654317 cites W1968925643 @default.
- W3194654317 cites W1969229361 @default.
- W3194654317 cites W1969913557 @default.
- W3194654317 cites W1971060618 @default.
- W3194654317 cites W1975278509 @default.
- W3194654317 cites W1978640748 @default.
- W3194654317 cites W1978661691 @default.
- W3194654317 cites W1983246741 @default.
- W3194654317 cites W1983651055 @default.
- W3194654317 cites W1986031245 @default.
- W3194654317 cites W1986569217 @default.
- W3194654317 cites W1986655848 @default.
- W3194654317 cites W1991389412 @default.
- W3194654317 cites W1995063875 @default.
- W3194654317 cites W1998652882 @default.
- W3194654317 cites W2006196877 @default.
- W3194654317 cites W2008103658 @default.
- W3194654317 cites W2015332717 @default.
- W3194654317 cites W2015838344 @default.
- W3194654317 cites W2016639612 @default.
- W3194654317 cites W2020893836 @default.
- W3194654317 cites W2022315563 @default.
- W3194654317 cites W2022372977 @default.
- W3194654317 cites W2028111423 @default.
- W3194654317 cites W2028805384 @default.
- W3194654317 cites W2029677015 @default.
- W3194654317 cites W2030695078 @default.
- W3194654317 cites W2032478134 @default.
- W3194654317 cites W2034795794 @default.
- W3194654317 cites W2037081745 @default.
- W3194654317 cites W2038060277 @default.
- W3194654317 cites W2042633155 @default.
- W3194654317 cites W2044099088 @default.
- W3194654317 cites W2046809665 @default.
- W3194654317 cites W2051022598 @default.
- W3194654317 cites W2051278851 @default.
- W3194654317 cites W2051651031 @default.
- W3194654317 cites W2052766715 @default.
- W3194654317 cites W2053058794 @default.
- W3194654317 cites W2056258485 @default.
- W3194654317 cites W2056336363 @default.
- W3194654317 cites W2058522210 @default.
- W3194654317 cites W2059542554 @default.
- W3194654317 cites W2060074114 @default.
- W3194654317 cites W2061083071 @default.
- W3194654317 cites W2062957366 @default.
- W3194654317 cites W2064858053 @default.
- W3194654317 cites W2074880818 @default.
- W3194654317 cites W2076279611 @default.
- W3194654317 cites W2079236567 @default.
- W3194654317 cites W2079595896 @default.
- W3194654317 cites W2082427266 @default.
- W3194654317 cites W2085581142 @default.
- W3194654317 cites W2092692878 @default.
- W3194654317 cites W2099486691 @default.
- W3194654317 cites W2100299975 @default.
- W3194654317 cites W2103722820 @default.
- W3194654317 cites W2111239144 @default.
- W3194654317 cites W2118876290 @default.
- W3194654317 cites W2120570409 @default.
- W3194654317 cites W2123122212 @default.
- W3194654317 cites W2136016201 @default.
- W3194654317 cites W2162804001 @default.
- W3194654317 cites W2165248259 @default.
- W3194654317 cites W2165336459 @default.
- W3194654317 cites W2167499172 @default.
- W3194654317 cites W2242584790 @default.
- W3194654317 cites W2278050634 @default.
- W3194654317 cites W2308746644 @default.
- W3194654317 cites W2425613501 @default.
- W3194654317 cites W2599718320 @default.
- W3194654317 cites W2791446266 @default.
- W3194654317 cites W2946553245 @default.
- W3194654317 cites W2956045400 @default.
- W3194654317 cites W2992656734 @default.
- W3194654317 cites W3012628191 @default.
- W3194654317 cites W2887338466 @default.