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- W3194690028 abstract "A healthy skin barrier supports the growth of commensal bacteria, which protect the host from pathogenic bacteria and virulence factors. In atopic dermatitis (AD), recent studies have pointed to a lack of microbial diversity in lesional and nonlesional skin. Dysregulation of the skin microflora in AD is believed to be influenced by epidermal barrier disruption and Th2-driven inflammation, in which interleukin (IL)-13 plays a major role. Tralokinumab is a first-in-class, fully human monoclonal antibody that has proven efficacious in improving signs and symptoms in moderate-to-severe AD by neutralizing the IL-13 cytokine." @default.
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- W3194690028 date "2021-09-01" @default.
- W3194690028 modified "2023-09-27" @default.
- W3194690028 title "28170 Neutralizing interleukin-13 increases skin microbial diversity: Results from a phase 3, randomized, double-blind, placebo-controlled trial with tralokinumab in adult patients with atopic dermatitis" @default.
- W3194690028 doi "https://doi.org/10.1016/j.jaad.2021.06.722" @default.
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