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- W3194780792 abstract "The application of bubbles in lab-on-chip devices has attracted considerable attention and is exerting an increasingly significant role in recent years due to its influential functions for fluid and particle manipulation. Herein, we demonstrated a simple air bubble trapping method based on the surface tension of hydrophobic chip material and demonstrated particle manipulation utilizing oscillating bubbles. The microfluidic device has a T-shaped junction structure with triangular obstacles, which allows us to transfer air-pocket generated due to non-synchronized liquid filling in the microchannel to stable bubbles attached to channel wall at the desired location. The trapped bubbles can maintain stable state at a flow rate of less than 50 μL/min. By activating bubbles with the sound wave at a specific frequency, we can achieve particle focusing, trapping, extraction and enrichment in a contact-free, label-free and continuous manner. The proposed bubble trapping method may serve as a reusable, detachable and biocompatible tool for broader bubble-based applications in chemical, biology, and engineering fields, such as drug delivery, cell focusing, as well as isolation of tumor cell." @default.
- W3194780792 created "2021-08-30" @default.
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- W3194780792 date "2021-11-01" @default.
- W3194780792 modified "2023-10-02" @default.
- W3194780792 title "Trapping stable bubbles in hydrophobic microchannel for continuous ultrasonic microparticle manipulation" @default.
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- W3194780792 doi "https://doi.org/10.1016/j.sna.2021.113045" @default.
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