FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3194783729> ?p ?o ?g. }

• W3194783729 endingPage "8507" @default.
• W3194783729 startingPage "8494" @default.
• W3194783729 abstract "Previous studies have shown that infiltration of capsaicin into the surgical site can prevent incision-induced spontaneous pain like behaviors and heat hyperalgesia. In the present study, we aimed to monitor primary sensory neuron Ca2+ activity in the intact dorsal root ganglia (DRG) using Pirt-GCaMP3 male and female mice pretreated with capsaicin or vehicle before the plantar incision. Intraplantar injection of capsaicin (0.05%) significantly attenuated spontaneous pain, mechanical, and heat hypersensitivity after plantar incision. The Ca2+ response in in vivo DRG and in in situ spinal cord was significantly enhanced in the ipsilateral side compared with contralateral side or naive control. Primary sensory nerve fiber length was significantly decreased in the incision skin area in capsaicin-pretreated animals detected by immunohistochemistry and placental alkaline phosphatase (PLAP) staining. Thus, capsaicin pretreatment attenuates incisional pain by suppressing Ca2+ response because of degeneration of primary sensory nerve fibers in the skin.SIGNIFICANCE STATEMENT Postoperative surgery pain is a major health and economic problem worldwide with ∼235 million major surgical procedures annually. Approximately 50% of these patients report uncontrolled or poorly controlled postoperative pain. However, mechanistic studies of postoperative surgery pain in primary sensory neurons have been limited to in vitro models or small numbers of neurons. Using an innovative, distinctive, and interdisciplinary in vivo populational dorsal root ganglia (DRG) imaging (>1800 neurons/DRG) approach, we revealed increased DRG neuronal Ca2+ activity from postoperative pain mouse model. This indicates widespread DRG primary sensory neuron plasticity. Increased neuronal Ca2+ activity occurs among various sizes of neurons but mostly in small-diameter and medium-diameter nociceptors. Capsaicin pretreatment as a therapeutic option significantly attenuates Ca2+ activity and postoperative pain." @default.
• W3194783729 created "2021-08-30" @default.
• W3194783729 creator A5003695291 @default.
• W3194783729 creator A5027088400 @default.
• W3194783729 creator A5045921211 @default.
• W3194783729 creator A5052377980 @default.
• W3194783729 creator A5058797264 @default.
• W3194783729 creator A5067715356 @default.
• W3194783729 creator A5086664284 @default.
• W3194783729 date "2021-08-27" @default.
• W3194783729 modified "2023-10-12" @default.
• W3194783729 title "<i>In Vivo</i> Calcium Imaging Visualizes Incision-Induced Primary Afferent Sensitization and Its Amelioration by Capsaicin Pretreatment" @default.
• W3194783729 cites W1570544222 @default.
• W3194783729 cites W1870440768 @default.
• W3194783729 cites W1974559976 @default.
• W3194783729 cites W1975293054 @default.
• W3194783729 cites W1976102723 @default.
• W3194783729 cites W1977871353 @default.
• W3194783729 cites W1986571558 @default.
• W3194783729 cites W1988975795 @default.
• W3194783729 cites W1989508055 @default.
• W3194783729 cites W1995971403 @default.
• W3194783729 cites W1999195261 @default.
• W3194783729 cites W2002991319 @default.
• W3194783729 cites W2003356426 @default.
• W3194783729 cites W2008545383 @default.
• W3194783729 cites W2008785662 @default.
• W3194783729 cites W2010067122 @default.
• W3194783729 cites W2010279333 @default.
• W3194783729 cites W2015977442 @default.
• W3194783729 cites W2017417965 @default.
• W3194783729 cites W2020288760 @default.
• W3194783729 cites W2025761537 @default.
• W3194783729 cites W2029263283 @default.
• W3194783729 cites W2030264500 @default.
• W3194783729 cites W2031264907 @default.
• W3194783729 cites W2035985955 @default.
• W3194783729 cites W2041806735 @default.
• W3194783729 cites W2047699709 @default.
• W3194783729 cites W2055546177 @default.
• W3194783729 cites W2073035767 @default.
• W3194783729 cites W2077481407 @default.
• W3194783729 cites W2079619166 @default.
• W3194783729 cites W2082612808 @default.
• W3194783729 cites W2088162801 @default.
• W3194783729 cites W2099249133 @default.
• W3194783729 cites W2106207830 @default.
• W3194783729 cites W2158335098 @default.
• W3194783729 cites W2162725513 @default.
• W3194783729 cites W2172201406 @default.
• W3194783729 cites W2195254757 @default.
• W3194783729 cites W2363933502 @default.
• W3194783729 cites W2511823098 @default.
• W3194783729 cites W2545728272 @default.
• W3194783729 cites W2771778226 @default.
• W3194783729 cites W2777500580 @default.
• W3194783729 cites W2792375985 @default.
• W3194783729 cites W2901492986 @default.
• W3194783729 cites W2903349195 @default.
• W3194783729 cites W2913992101 @default.
• W3194783729 cites W2944774806 @default.
• W3194783729 cites W2950315115 @default.
• W3194783729 cites W2958761519 @default.
• W3194783729 cites W2965944158 @default.
• W3194783729 cites W2996579247 @default.
• W3194783729 cites W3013779348 @default.
• W3194783729 cites W3086960044 @default.
• W3194783729 cites W3092924046 @default.
• W3194783729 cites W3145491592 @default.
• W3194783729 cites W44008663 @default.
• W3194783729 doi "https://doi.org/10.1523/jneurosci.0457-21.2021" @default.
• W3194783729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8513701" @default.
• W3194783729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34452938" @default.
• W3194783729 hasPublicationYear "2021" @default.
• W3194783729 type Work @default.
• W3194783729 sameAs 3194783729 @default.
• W3194783729 citedByCount "9" @default.
• W3194783729 countsByYear W31947837292022 @default.
• W3194783729 countsByYear W31947837292023 @default.
• W3194783729 crossrefType "journal-article" @default.
• W3194783729 hasAuthorship W3194783729A5003695291 @default.
• W3194783729 hasAuthorship W3194783729A5027088400 @default.
• W3194783729 hasAuthorship W3194783729A5045921211 @default.
• W3194783729 hasAuthorship W3194783729A5052377980 @default.
• W3194783729 hasAuthorship W3194783729A5058797264 @default.
• W3194783729 hasAuthorship W3194783729A5067715356 @default.
• W3194783729 hasAuthorship W3194783729A5086664284 @default.
• W3194783729 hasBestOaLocation W31947837291 @default.
• W3194783729 hasConcept C118552586 @default.
• W3194783729 hasConcept C126322002 @default.
• W3194783729 hasConcept C142724271 @default.
• W3194783729 hasConcept C150903083 @default.
• W3194783729 hasConcept C15490471 @default.
• W3194783729 hasConcept C155164980 @default.
• W3194783729 hasConcept C160145004 @default.
• W3194783729 hasConcept C169760540 @default.
• W3194783729 hasConcept C170493617 @default.
• W3194783729 hasConcept C172659308 @default.

• next