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• W3194785917 abstract "Abstract The objective of this study is to label Amoxicillin with radioactive iodine ( 125 I-AC) via direct electrophilic substitution to act as a promising tracer for inflammation imaging. The highest labeling yield of 80% was achieved after studying all the parameters affecting the labeling reaction using Iodogen (IG) as an oxidizing agent. Molecular Modeling Structure was done using MOE program to predict the suitable 125 I position. The product structure was established by a cold iodination reaction using Iodine-127. Biological evaluation of ( 125 I-AC) was carried out using groups of inflamed mice with different exogenous agents such as E.Coli and Turpentine oil. The ( 125 I-AC) shows an in vitro stability of about 97% after 24 h.While doing in vivo studies over 4 h, the tracer stability of 99% was observed." @default.
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• W3194785917 date "2021-08-23" @default.
• W3194785917 modified "2023-09-27" @default.
• W3194785917 title "¹²⁵I–Amoxicillin preparation as a guide tracer for inflammation detection" @default.
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• W3194785917 doi "https://doi.org/10.1515/ract-2021-1077" @default.
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