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- W3194850308 endingPage "1503" @default.
- W3194850308 startingPage "1489" @default.
- W3194850308 abstract "BAF complexes are multi-subunit chromatin remodelers, which have a fundamental role in genomic regulation. Large-scale sequencing efforts have revealed frequent BAF complex mutations in many human diseases, particularly in cancer and neurological disorders. These findings not only underscore the importance of the BAF chromatin remodelers in cellular physiological processes, but urge a more detailed understanding of their structure and molecular action to enable the development of targeted therapeutic approaches for diseases with BAF complex alterations. Here, we review recent progress in understanding the composition, assembly, structure, and function of BAF complexes, and the consequences of their disease-associated mutations. Furthermore, we highlight intra-complex subunit dependencies and synthetic lethal interactions, which have emerged as promising treatment modalities for BAF-related diseases." @default.
- W3194850308 created "2021-08-30" @default.
- W3194850308 creator A5047930698 @default.
- W3194850308 creator A5050576705 @default.
- W3194850308 creator A5051753736 @default.
- W3194850308 creator A5079256238 @default.
- W3194850308 date "2021-08-25" @default.
- W3194850308 modified "2023-09-27" @default.
- W3194850308 title "The BAF chromatin remodeling complexes: structure, function, and synthetic lethalities" @default.
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