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- W3194852178 endingPage "2309" @default.
- W3194852178 startingPage "2295" @default.
- W3194852178 abstract "Long bone fractures are one of the most common and costly medical conditions encountered after trauma. Characterization of the biology of fracture healing and development of potential medical interventions generally involves animal models of fracture healing using varying genetic or treatment groups, then analyzing relative repair success via the synthesis of diverse assessment methodologies. Murine models are some of the most widely used given their low cost, wide variety of genetic variants, and rapid breeding and maturation. This review addresses key concerns regarding fracture repair investigations in mice and may serve as a guide in conducting and interpreting such studies. Specifically, this review details the procedures, highlights relevant parameters, and discusses special considerations for the selection and integration of the major modalities used for quantifying fracture repair in such studies, including X-ray, microcomputed tomography, histomorphometric, biomechanical, gene expression and biomarker analyses." @default.
- W3194852178 created "2021-08-30" @default.
- W3194852178 creator A5011064991 @default.
- W3194852178 creator A5034416233 @default.
- W3194852178 creator A5049815429 @default.
- W3194852178 creator A5056738995 @default.
- W3194852178 creator A5077185490 @default.
- W3194852178 date "2021-09-10" @default.
- W3194852178 modified "2023-10-14" @default.
- W3194852178 title "Methodology, selection, and integration of fracture healing assessments in mice" @default.
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- W3194852178 doi "https://doi.org/10.1002/jor.25172" @default.
- W3194852178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8542592" @default.
- W3194852178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34436797" @default.