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- W3194865429 abstract "Brain's modular connectivity gives this organ resilience and adaptability. The ageing process alters the organised modularity of the brain and these changes are further accentuated by neurodegeneration, leading to disorganisation. To understand this further, we analysed modular variability-heterogeneity of modules-and modular dissociation-detachment from segregated connectivity-in two ageing cohorts and a mixed cohort of neurodegenerative diseases. Our results revealed that the brain follows a universal pattern of high modular variability in metacognitive brain regions: the association cortices. The brain in ageing moves towards a segregated modular structure despite presenting with increased modular heterogeneity-modules in older adults are not only segregated, but their shape and size are more variable than in young adults. In the presence of neurodegeneration, the brain maintains its segregated connectivity globally but not locally, and this is particularly visible in dementia with Lewy bodies and Parkinson's disease dementia; overall, the modular brain shows patterns of differentiated pathology." @default.
- W3194865429 created "2021-08-30" @default.
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- W3194865429 date "2021-08-16" @default.
- W3194865429 modified "2023-10-18" @default.
- W3194865429 title "The functional brain favours segregated modular connectivity at old age unless affected by neurodegeneration" @default.
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- W3194865429 doi "https://doi.org/10.1038/s42003-021-02497-0" @default.
- W3194865429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8367990" @default.
- W3194865429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34400752" @default.
- W3194865429 hasPublicationYear "2021" @default.
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