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- W3194865809 endingPage "1543" @default.
- W3194865809 startingPage "1529" @default.
- W3194865809 abstract "Multiple system atrophy (MSA) is a challenging neurodegenerative disorder with a difficult and often inaccurate early diagnosis, still lacking effective treatment. It is characterized by a highly variable clinical presentation with parkinsonism, cerebellar ataxia, autonomic dysfunction, and pyramidal signs, with a rapid progression and an aggressive clinical course. The definite MSA diagnosis is only possible post-mortem, when the presence of distinctive oligodendroglial cytoplasmic inclusions (GCIs), mainly composed of misfolded and aggregated α-Synuclein (α-Syn) is demonstrated. The process of α-Syn accumulation and aggregation within oligodendrocytes is accepted one of the main pathological events underlying MSA. However, MSA is considered a multifactorial disorder with multiple pathogenic events acting together including neuroinflammation, oxidative stress, and disrupted neurotrophic support, among others. The discussed here treatment approaches are based on our current understanding of the pathogenesis of MSA and the results of preclinical and clinical therapeutic studies conducted over the last 2 decades. We summarize leading disease-modifying approaches for MSA including targeting α-Syn pathology, modulation of neuroinflammation, and enhancement of neuroprotection. In conclusion, we outline some challenges related to the need to overcome the gap in translation between preclinical and clinical studies towards a successful disease modification in MSA." @default.
- W3194865809 created "2021-08-30" @default.
- W3194865809 creator A5010631102 @default.
- W3194865809 creator A5015155587 @default.
- W3194865809 creator A5061678972 @default.
- W3194865809 date "2021-08-16" @default.
- W3194865809 modified "2023-09-30" @default.
- W3194865809 title "Current experimental disease-modifying therapeutics for multiple system atrophy" @default.
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