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- W3194875500 abstract "Solitary fibrous tumor (SFT) is a rare soft tissue sarcoma subtype which mainly affects adults in the fifth and sixth decades of life. Originally part of a spectrum of tumors called hemangiopericytomas, classification has been refined such that SFTs now represent a distinct subtype. The identification of NAB2-STAT6 fusion in virtually all SFTs has further aided to define this rare subgroup. SFTs have a spectrum of behavior from benign to malignant, with evidence suggesting risk of metastases related to age at diagnosis, extent of necrosis, mitotic rate and tumor size. The standard treatment for localized disease is surgical excision with or without radiotherapy. Retrospective and prospective evidence suggests antiangiogenic treatment is effective for unresectable disease. Further translational work is required to understand the biology driving the differential behavior and identify more effective treatments for patients with metastatic disease." @default.
- W3194875500 created "2021-08-30" @default.
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- W3194875500 date "2021-09-01" @default.
- W3194875500 modified "2023-10-12" @default.
- W3194875500 title "Solitary fibrous tumor: molecular hallmarks and treatment for a rare sarcoma" @default.
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- W3194875500 doi "https://doi.org/10.2217/fon-2021-0030" @default.
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