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- W3194983121 abstract "Abstract Since the totemic achievement of human-induced pluripotent stem cells (iPSCs) in the stem cell field, we have witnessed a remarkable expansion in publications related to this discovery that could have central relevance to health and disease. One example of an offshoot from this achievement was the differentiation of iPSCs utilizing 3D in vitro models that resulted in the formation of organoids, such as lung organoids. These fascinating miniature organs are robustly generated through the process of self-assembly in response to morphogenetic cues. Organoids beautifully resemble the architecture and function of their in vivo counterparts. The marriage of this system and genome-editing techniques has powerfully advanced our knowledge of human lung biology, disease modeling, and drug discoveries, particularly where animal models are limited. Presently, human iPSC–derived lung organoids are developmentally nascent compared to their adult tissues. A deeper comprehension of the principles governing lung organogenesis combined with “lung-on-a-chip” technology could reconcile diverse cellular, vascular, and matrix strategies to reconstruct a complete niche in vitro. Ultimately, future progress is dependent on the convergence of multiple disciplines of biomedical science. The epochal impact of iPSC-lung organoid studies heralds their coming-of-age in creating novel, personalized therapeutics for regenerative medicine." @default.
- W3194983121 created "2021-08-30" @default.
- W3194983121 creator A5039238222 @default.
- W3194983121 creator A5043292712 @default.
- W3194983121 date "2021-01-01" @default.
- W3194983121 modified "2023-10-18" @default.
- W3194983121 title "Looking back, moving forward" @default.
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