Matches in SemOpenAlex for { <https://semopenalex.org/work/W3194998165> ?p ?o ?g. }
- W3194998165 abstract "Blood exchanges between young and old partners demonstrate old blood has a detrimental effect on brain health of young animals. Previous studies primarily investigate soluble blood factors, such as transforming growth factor-beta, on the brain and the blood-brain barrier (BBB). However, the role of blood cellular components, particularly erythrocytes, has not been defined. Erythrocyte morphology and rigidity change as mammals age, altering their transport within the capillary bed. This impacts downstream biological events, such as the release of reactive oxygen species and hemoglobin, potentially compromising the BBB. Here, a micro electrical BBB (µE-BBB), with cocultured endothelial and astrocytic cells, and a built-in trans-endothelial electrical resistance (TEER) system is described to monitor the effect of capillary shear stress on erythrocytes derived from young and old mice and people and the subsequent effects of these cells on BBB integrity. This is monitored by the passage of fluorescein isothiocyanate-dextran and real-time profiling of TEER across the BBB after old and young erythrocyte exposure. Compared to young erythrocytes, old erythrocytes induce an increased permeability by 42% and diminished TEER by 2.9% of the µE-BBB. These results suggest that changes in circulating erythrocytes are a biomarker of aging in the context of BBB integrity." @default.
- W3194998165 created "2021-08-30" @default.
- W3194998165 creator A5005685784 @default.
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- W3194998165 date "2021-08-16" @default.
- W3194998165 modified "2023-09-26" @default.
- W3194998165 title "Erythrocytes, a New Contributor to Age‐Associated Loss of Blood–Brain Barrier Integrity" @default.
- W3194998165 cites W1504167407 @default.
- W3194998165 cites W1579526370 @default.
- W3194998165 cites W1647542124 @default.
- W3194998165 cites W1678960821 @default.
- W3194998165 cites W1847104216 @default.
- W3194998165 cites W19630745 @default.
- W3194998165 cites W1969190307 @default.
- W3194998165 cites W1973890872 @default.
- W3194998165 cites W1980664953 @default.
- W3194998165 cites W1983061009 @default.
- W3194998165 cites W1983973676 @default.
- W3194998165 cites W1992758695 @default.
- W3194998165 cites W1992924393 @default.
- W3194998165 cites W1994504773 @default.
- W3194998165 cites W1994812037 @default.
- W3194998165 cites W1994873128 @default.
- W3194998165 cites W1996612611 @default.
- W3194998165 cites W1998567323 @default.
- W3194998165 cites W2001726213 @default.
- W3194998165 cites W2005824957 @default.
- W3194998165 cites W2008965285 @default.
- W3194998165 cites W2009144884 @default.
- W3194998165 cites W2010255287 @default.
- W3194998165 cites W2015744673 @default.
- W3194998165 cites W2019471670 @default.
- W3194998165 cites W2023621655 @default.
- W3194998165 cites W2025688778 @default.
- W3194998165 cites W2030994996 @default.
- W3194998165 cites W2037650857 @default.
- W3194998165 cites W2044476057 @default.
- W3194998165 cites W2059661208 @default.
- W3194998165 cites W2062341564 @default.
- W3194998165 cites W2065682534 @default.
- W3194998165 cites W2070573684 @default.
- W3194998165 cites W2076006895 @default.
- W3194998165 cites W2080956998 @default.
- W3194998165 cites W2082056539 @default.
- W3194998165 cites W2083682299 @default.
- W3194998165 cites W2085754209 @default.
- W3194998165 cites W2091680093 @default.
- W3194998165 cites W2092459487 @default.
- W3194998165 cites W2101957440 @default.
- W3194998165 cites W2103943414 @default.
- W3194998165 cites W2109290881 @default.
- W3194998165 cites W2125281412 @default.
- W3194998165 cites W2128590828 @default.
- W3194998165 cites W2132898527 @default.
- W3194998165 cites W2133057534 @default.
- W3194998165 cites W2134135049 @default.
- W3194998165 cites W2140120525 @default.
- W3194998165 cites W2148361935 @default.
- W3194998165 cites W2149701800 @default.
- W3194998165 cites W2155075033 @default.
- W3194998165 cites W2161908936 @default.
- W3194998165 cites W2164091121 @default.
- W3194998165 cites W2165282158 @default.
- W3194998165 cites W2287376001 @default.
- W3194998165 cites W2415637550 @default.
- W3194998165 cites W2471284989 @default.
- W3194998165 cites W2490222298 @default.
- W3194998165 cites W2529440777 @default.
- W3194998165 cites W2550166770 @default.
- W3194998165 cites W2554492400 @default.
- W3194998165 cites W2559141477 @default.
- W3194998165 cites W2560319914 @default.
- W3194998165 cites W2564300321 @default.
- W3194998165 cites W2580804869 @default.
- W3194998165 cites W2601589334 @default.
- W3194998165 cites W2738354272 @default.
- W3194998165 cites W2763432708 @default.
- W3194998165 cites W2790182771 @default.
- W3194998165 cites W2912639258 @default.
- W3194998165 cites W2917728658 @default.
- W3194998165 cites W2945754456 @default.
- W3194998165 cites W2950636079 @default.
- W3194998165 cites W2989048325 @default.
- W3194998165 cites W3000511359 @default.
- W3194998165 cites W3009338790 @default.
- W3194998165 cites W3029504057 @default.
- W3194998165 cites W3084332345 @default.
- W3194998165 cites W3092499620 @default.
- W3194998165 cites W3103505494 @default.
- W3194998165 cites W3194998165 @default.
- W3194998165 cites W4237905074 @default.
- W3194998165 cites W86165068 @default.
- W3194998165 doi "https://doi.org/10.1002/advs.202101912" @default.
- W3194998165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8529433" @default.
- W3194998165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34396716" @default.