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- W3195011437 abstract "BACKGROUND AND AIM: Air pollution is a known risk factor for cardiovascular and respiratory morbidity and mortality. One mechanism explaining the observed associaitons is that exposure to air pollution induces inflammation processes. This link from an epidemiological perspective has been investigated for Particulate Matter (PM) and for nitrogen oxides (NOx). This study aims to evaluate the association between air pollution and inflammation using immune blood markers. METHODS: We evaluated the short-term association between PM10, PM2.5, NO2, NO, and routine immune blood markers (white blood cells (WBC), lymphocytes, and neutrophils) on subjects whose had routine blood sample tests in Padova, Italy, from 2009 to 2019. We estimated the short-term association between each immune blood markers and pollutant using a linear regression model with generalized estimating equations combined with distributed lag non-linear models to assess both delayed effect in time (till 21 days) and the possible non-linear exposure-response relationship. Models were adjusted for age, gender, temperature, relative humidity, pressure, and seasonality. RESULTS:More than 500,000 blood samples were collected among 169,508 subjects. We observed a non-linear positive association between NOx and circulating immune cells. An increase of 190 (10^6/L) WBC (CI: 141-238), 60 (10^6/L) neutrophiles (CI: 23-98) and 86 (10^6/L) lymphocytes (CI: 69-104) was detected for an IQR increase in NO2. PM10 and PM2.5 showed a non-linear relationship with WBC, neutrophils, and lymphocytes. The overall effect was detectable as positively associated with increased levels of circulating immune cells from 20 µg/m^3 of PM10 and 15 µg/m^3 of PM2.5. CONCLUSIONS:Air pollution has an impact on the immune response measured with immune blood markers. NOx shows a more evident pro-inflammatory effect from low concentrations without a threshold effect. PM has an overall impact on circulating immune cells detectable at higher exposures. These results reinforce the evidence of a link between air pollution and systemic inflammation and oxidation. KEYWORDS: Oxides of nitrogen, Particulate matter, Short-term exposure" @default.
- W3195011437 created "2021-08-30" @default.
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- W3195011437 date "2021-08-23" @default.
- W3195011437 modified "2023-10-16" @default.
- W3195011437 title "Pro-inflammatory effects of air pollution using simple blood marker" @default.
- W3195011437 doi "https://doi.org/10.1289/isee.2021.p-565" @default.
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