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- W3195012704 abstract "The crAss-like phages are ubiquitous and highly abundant members of the human gut virome that infect commensal bacteria of the order Bacteroidales. Although incapable of lysogeny, these viruses demonstrate long-term persistence in the human gut microbiome, dominating the virome in some individuals.Here we show that rapid phase variation of alternate capsular polysaccharides in Bacteroides intestinalis cultures plays an important role in a dynamic equilibrium between phage sensitivity and resistance, allowing phage and bacteria to multiply in parallel. The data also suggests the role of a concomitant phage persistence mechanism associated with delayed lysis of infected cells, similar to carrier state infection. From an ecological and evolutionary standpoint, this type of phage-host interaction is consistent with the Piggyback-the-Winner model, which suggests a preference towards lysogenic or other benign forms of phage infection when the host is stably present at high abundance.Long-term persistence of bacteriophage and host could result from mutually beneficial mechanisms driving bacterial strain-level diversity and phage survival in complex environments." @default.
- W3195012704 created "2021-08-30" @default.
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- W3195012704 date "2021-08-18" @default.
- W3195012704 modified "2023-10-09" @default.
- W3195012704 title "Long-term persistence of crAss-like phage crAss001 is associated with phase variation in Bacteroides intestinalis" @default.
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- W3195012704 doi "https://doi.org/10.1186/s12915-021-01084-3" @default.
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