FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3195047136> ?p ?o ?g. }

• W3195047136 endingPage "4301" @default.
• W3195047136 startingPage "4301" @default.
• W3195047136 abstract "Correlative studies of clinical studies for hematological malignancies have implicated that less differentiated, CD8+-dominant CAR T cell products have greater antitumor activity. Here, we have investigated whether the differentiation status of CAR T cell products affects their antitumor activity in preclinical models of solid tumors. We explored if different activation/expansion protocols, as well as different co-stimulatory domains in the CAR construct, influence the short- and long-term efficacy of CAR T cells against HER2-positive tumors. We generated T cell products that range from the most differentiated (CD28.z; OKT3-antiCD28/RPMI expansion) to the least differentiated (41BB.z; OKT3-RetroNectin/LymphoONE expansion), as judged by cell surface expression of the differentiation markers CCR7 and CD45RA. While the effect of differentiation status was variable with regard to antigen-specific cytokine production, the most differentiated CD28.z CAR T cell products, which were enriched in effector memory T cells, had the greatest target-specific cytolytic activity in vitro. These products also had a greater proliferative capacity and maintained CD4+ T cells upon repeated stimulation in vitro. In vivo, differentiated CD28.z CAR T cells also had the greatest antitumor activity, resulting in complete response. Our results highlight that it is critical to optimize CAR T cell production and that optimal product characteristics might depend on the targeted antigen and/or cancer." @default.
• W3195047136 created "2021-08-30" @default.
• W3195047136 creator A5007530261 @default.
• W3195047136 creator A5041825095 @default.
• W3195047136 creator A5056105964 @default.
• W3195047136 creator A5056919449 @default.
• W3195047136 creator A5082945980 @default.
• W3195047136 date "2021-08-26" @default.
• W3195047136 modified "2023-10-18" @default.
• W3195047136 title "Cytolytic Activity of CAR T Cells and Maintenance of Their CD4+ Subset Is Critical for Optimal Antitumor Activity in Preclinical Solid Tumor Models" @default.
• W3195047136 cites W1515846933 @default.
• W3195047136 cites W1586302079 @default.
• W3195047136 cites W1617495083 @default.
• W3195047136 cites W1974351164 @default.
• W3195047136 cites W1982795546 @default.
• W3195047136 cites W1990568245 @default.
• W3195047136 cites W1994257755 @default.
• W3195047136 cites W1994416240 @default.
• W3195047136 cites W2018241292 @default.
• W3195047136 cites W2028460943 @default.
• W3195047136 cites W2056100438 @default.
• W3195047136 cites W2060169824 @default.
• W3195047136 cites W2068071851 @default.
• W3195047136 cites W2071548401 @default.
• W3195047136 cites W2071966111 @default.
• W3195047136 cites W2078992149 @default.
• W3195047136 cites W2092109378 @default.
• W3195047136 cites W2093322080 @default.
• W3195047136 cites W2125028197 @default.
• W3195047136 cites W2142263069 @default.
• W3195047136 cites W2157612047 @default.
• W3195047136 cites W2167279371 @default.
• W3195047136 cites W2213952892 @default.
• W3195047136 cites W2219506342 @default.
• W3195047136 cites W2276612482 @default.
• W3195047136 cites W2285239684 @default.
• W3195047136 cites W2342423058 @default.
• W3195047136 cites W2343125831 @default.
• W3195047136 cites W2401536218 @default.
• W3195047136 cites W2606163602 @default.
• W3195047136 cites W2743510679 @default.
• W3195047136 cites W2768550677 @default.
• W3195047136 cites W2772411017 @default.
• W3195047136 cites W2773804840 @default.
• W3195047136 cites W2787301955 @default.
• W3195047136 cites W2803369586 @default.
• W3195047136 cites W2883513277 @default.
• W3195047136 cites W2911543360 @default.
• W3195047136 cites W2912069976 @default.
• W3195047136 cites W3004471282 @default.
• W3195047136 cites W3012325124 @default.
• W3195047136 cites W3015898564 @default.
• W3195047136 cites W3028983520 @default.
• W3195047136 cites W3032578076 @default.
• W3195047136 cites W3082855561 @default.
• W3195047136 cites W3108012933 @default.
• W3195047136 cites W3112947740 @default.
• W3195047136 cites W3122724341 @default.
• W3195047136 cites W3125546746 @default.
• W3195047136 cites W3133229959 @default.
• W3195047136 cites W3134165232 @default.
• W3195047136 cites W3135062026 @default.
• W3195047136 cites W3172144992 @default.
• W3195047136 cites W4313368930 @default.
• W3195047136 doi "https://doi.org/10.3390/cancers13174301" @default.
• W3195047136 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8428348" @default.
• W3195047136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34503109" @default.
• W3195047136 hasPublicationYear "2021" @default.
• W3195047136 type Work @default.
• W3195047136 sameAs 3195047136 @default.
• W3195047136 citedByCount "4" @default.
• W3195047136 countsByYear W31950471362022 @default.
• W3195047136 countsByYear W31950471362023 @default.
• W3195047136 crossrefType "journal-article" @default.
• W3195047136 hasAuthorship W3195047136A5007530261 @default.
• W3195047136 hasAuthorship W3195047136A5041825095 @default.
• W3195047136 hasAuthorship W3195047136A5056105964 @default.
• W3195047136 hasAuthorship W3195047136A5056919449 @default.
• W3195047136 hasAuthorship W3195047136A5082945980 @default.
• W3195047136 hasBestOaLocation W31950471361 @default.
• W3195047136 hasConcept C147483822 @default.
• W3195047136 hasConcept C148125776 @default.
• W3195047136 hasConcept C154317977 @default.
• W3195047136 hasConcept C167672396 @default.
• W3195047136 hasConcept C185592680 @default.
• W3195047136 hasConcept C202751555 @default.
• W3195047136 hasConcept C203014093 @default.
• W3195047136 hasConcept C2776090121 @default.
• W3195047136 hasConcept C3875195 @default.
• W3195047136 hasConcept C502942594 @default.
• W3195047136 hasConcept C55493867 @default.
• W3195047136 hasConcept C73588182 @default.
• W3195047136 hasConcept C86803240 @default.
• W3195047136 hasConcept C8891405 @default.
• W3195047136 hasConcept C95444343 @default.
• W3195047136 hasConceptScore W3195047136C147483822 @default.
• W3195047136 hasConceptScore W3195047136C148125776 @default.
• W3195047136 hasConceptScore W3195047136C154317977 @default.

• next